Isolation and characterization of an acetylated impurity in Escherichia coli-derived recombinant human interleukin-10 (IL-10) drug substance

Pharmaceutical Research

Volumn 14, Issue 6, 1997, Pages 833-836

  Pflumm, Mollie N ^a   Gruber, Stephen C ^a   Tsarbopoulos, Anthony ^a   Wylie, David ^a   Pramanik, Birendra ^a   Bausch, James N ^a   Patel, Suman T ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BIOGEN   (United States)

Author keywords

Impurity; Interleukin 10; Recombinant proteins; N acetylated lysine

Indexed keywords

RECOMBINANT INTERLEUKIN 10;

ARTICLE; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG ISOLATION; DRUG MANUFACTURE; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 0030996814     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012127228239     Document Type: Article

References (24)

1. K. W. Moore, A. O'Garra, R. deWaal Malefyt, P. Vieiria, and T. R. Mosmann. Annu. Rev. Immunol. 11:165-190 (1993).
2. L Thompson-Snipes, V. Dhar, M. W. Bond, T. R. Mosmann, K. W. Moore, and D. Rennick. J. Exp. Med. 173:507-510 (1991).
3. N. F. Go, B. E. Castle, R. Barrett, R. Kastelstein, W. Dang, T. R. Mosmann, K. W. Moore, and M. Howard. J. Exp. Med 172:1625-1631 (1990).
4. F. Roussel, E. Garcia, T. Defrance, C. Peronne, D.-H. Hsu, R. Kastelein, K. W. Moore, and J. Banchereau. Proc. Natl. Acad. Sci USA 89:1890-1893 (1992).
5. D. F. Fiorentino, M. W. Bond, and T. R. Mosmann. J. Exp. Med 170:2081-2095 (1989).
6. R. deWaal-Malefyt, J. Haanen, H. Spits, M.-G. Roncarolo, A. teVelde, C. Figdor, K. Johnson, R. Kastelstein, H. Yssel, and J. E. deVries. J. Exp. Med. 174:915-924 (1991).
7. T. R. Mosmann and K. W. Moore. Immunol. Today 12: A49-A53. (1991).
8. D. F. Fiorentino, A. Zlotnik, P Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. J. Immunol. 146:3444-3451 (1991).
9. T. Takeuchi, R. P. Lowry, and B. Konieczny. Transplantation 53:1281-1294 (1992).
10. S. C. B. Van, B. W. Grinnell, and F. Wold. TIBS. 14:264-268 (1989).
11. S. Y. Roth and C. D. Allis. Cell 87:5-8 (1996).
12. K-K. Han and A. Martinage. Int. J. Biochem. 24:19-28 (1992).
13. D. Wellner, C. Panneerselvam, and B. L. Horecker. Proc. Natl. Acad. Sci., U.S.A. 87:1947-1949 (1990).
14. P. J. T. A. Groenen, K. B. Merck, W. W. DeJong, and H. Bloemendal. Eur. J. Biochem. 225:1-19 (1994).
15. T. Takao, M. Kobayashi, O. Nishimura, and Y. Shimonishi. J. Biol. Chem. 262:3541-3547 (1987).
16. G. Padrón, V. Besada, A. Agraz, Y. Quinones, L. Herrera, Y. Shimonishi, and T. Takao. Anal. Chim. Acta. 223:361-369 (1989).
17. F. E. Ross, T. Zamborelli, A. C. Herman, C.-H. Yeh, N. I. Tedeschi, and E. S. Luedke. Techniques in Protein Chem. (D. Marshak, Ed.), Vol. VII, Academic Press, New York, 1996, pp. 201-207.
18. J. Samhrook, E. F. Fritsch, and T. Maniatis. Molecular Cloning: A Laboratory Manual 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y. 1989.
19. G. R. Drapeau, Y Boily, and J. Houmard. J. Biol. Chem. 247:6720-6726 (1972).
20. E. R. Hoff and R. C. Chloupek. in Methods in Enzymology. (B. L. Karger and W. S. Hancock, Eds.), Vol. 271, Academic Press, New York, 1996, pp. 51-68.
21. B. Sunqvist, I. Kamensky, P. Hakansson, J. Kjelberg, M. Salehpour, S. Widdiysekera, J. Fohlman, P. A. Peterson, and P. Roepstorff. Biomed. Mass Spectrom. 11:242-257 (1984).
22. A. Tsarbopoulos, G. W. Becker, J. L. Occolowitz, and I. Jardine. Anal. Biochem. 171:113-123 (1988).
23. B. A. Shirley. Protein Stability and Folding. Vol. 40 Humana Press, Totowa, New Jersey, 1995, p. 178.
24. G. R. Stark. Biochemistry 4:1030-1036 (1965).