Pharmacologic approach of hypoxemia in ARDS patients

Intensivmedizin und Notfallmedizin

Volumn 34, Issue 3, 1997, Pages 179-197

  Puybasset, L ^a   Rouby, J J ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

almitrine; ARDS; cyclooxygenase inhibitors; hypoxemia; inhaled; nitric oxide

Indexed keywords

ACETYLSALICYLIC ACID; ALMITRINE; INDOMETACIN; MECLOFENAMIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADULT RESPIRATORY DISTRESS SYNDROME; HUMAN; HYPOXEMIA; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; REVIEW;

EID: 0030996795     PISSN: 01753851     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003900050036     Document Type: Review

References (169)

1. Furchgott RF, Zawadski JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373-376
2. Palmer RMJ, Ferrige AG, Moncada SA (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526
3. Higenbottam T, Pepke-Zaba J, Scott J, Woolman P, Coutts C, Wallwork J (1988) Inhaled "endothelial derived-relaxing factor" (EDRF) in primary hypertension (PPH). Am Rev Resp Dis Suppl 137:A107 (Abstract)
4. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 338:1173-1174
5. Fratacci MD, Frostell CG, Chen TY, Wain JC, Robinson DR, Zapol WM (1991) Inhaled nitric oxide: A selective pulmonary vasodilator of heparin-Protamine vasoconstriction in sheep. Anesthesiology 75:990-999
6. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM (1991) Inhaled nitric oxide: A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038-2047
7. Pison U, Lopez FA, Heidelmeyer CF, Rossaint R, Falke K (1993) Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. J Appl Physiol 74:1287-1292
8. Roberts JD, Polaner DM, Lang P, Zapol WM (1992) Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 340:818-819
9. Freden F, Wei SZ, Berglund JE, Frostell C, Hedenstrierna G (1995) Nitric oxide modulation of pulmonary blood flow distribution in lobar hypoxia. Anesthesiology 82:1216-1225
10. Weitzberg E, Rudehill A, Alving K, Lundberg JM (1991) Nitric oxide inhalation selectively attenuates pulmonary hypertension and arterial hypoxia in porcine endotoxin shock. Acta Physiol Scand 143:451-452
11. Berger JI, Gibson RL, Redding GJ, Standaert TA, Clarke WR, Truog WE (1993) Effect of inhaled nitric oxide during group B streptococcal sepsis in piglets. Am Rev Resp Dis 147:1080-1086
12. Dyar O, Young JD, Xiong L, John S (1993) Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep. Br J Anaesth 71:702-708
13. Dahm P, Blomquist S, Martensson L, Thoine J, Zoucas E (1994) Circulatory and ventilatory effects of intermittent nitric oxide inhalation during porcine endotoxemia. J Trauma 37:769-777
14. Kavanach BP, Mouchawar A, Goldsmith J, Pearl RG (1994) Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced acute lung injury. J Appl Physiol 76:1324-1329
15. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399-405
16. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD, Zapol WM (1994) Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Anesthesiology 80:761-770
17. Puybasset L, Stewart TE, Rouby JJ, Cluzel P, Mourgeon E, Belin MF, Arthaud M, Landault C, Viars P (1994) Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with ARDS. Anesthesiology 80:1254-1267
18. Puybasset L, Rouby JJ, Mourgeon E, Stewart TE, Cluzel P, Belin MF, Grenier P, Arthaud M, Poète P, Bodin L, Korinek AM, Viars P (1994) Inhaled nitric oxide in acute respiratory failure: Dose-response curves. Intensive Care Med 20:319-327
19. Young JD, Brampton WJ, Knighton JD, Finfer SR (1994) Inhaled nitric oxide in acute respiratory failure in adults. Br J Anaesth 73:499-502
20. Rich FR, Murphy GD, Roos CM, Johns RA (1993) Inhaled nitric oxide: Selective pulmonary vasodilation in cardiac surgical patients. Anesthesiology 78:1028-1035
21. Girard C, Lehot J, Pannetier J, Filley S, French P, Estanove S (1992) Inhaled nitric oxide after mitral valve replacement in patients with chronic pulmonary hypertension. Anesthesiology 77:880-883
22. Adnot S, Kouyoumdjian C, Defouilloy C, Andrivet P, Sediame S, Herigauklt R, Fratacci MD (1993) Hemodynamic and gas exchange responses to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Resp Dis 148:310-316
23. Moinard J, Manier G, Pillet O, Castaing Y (1994) Effect of inhaled nitric oxide on hemodynamics and VA/Q inequalities in patients with chronic obstructive pulmonary disease. Am J Resp Crit Care Med 149:1482-1487
24. Swart M, Smithies M (1995) Nitric oxide in acute respiratory distress syndrome. Acta Anaesthesiol Scand 39:69-74
25. Stenqvist O, Kjelltoft B, Lundin S (1993) Evaluation of a new system for ventilatory administration of nitric oxide. Acta Anaesthesiol Scand 37:687-691
26. Wessel DL, Adatia I, Thompson JE, Hickey PR (1994) Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension. Crit Care Med 22:930-938
27. Dubé L, Francoeur M, Troncy E, Carrier R, Blaise G (1995) Comparison of two administration techniques of inhaled nitric oxide on nitrogen dioxide production. Can J Anaesth 42:922-927
28. Nishimura M, Hess D, Kacmarek RM, Ritz R, Hurford WE (1995) Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation and inspired oxygen fraction. Anesthesiology 82:1246-1254
29. Wysocki M, Delclaux C, Roupie E, Langeron O, Liu N, Herman B, Lemaire F, Brochard L (1994) Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med 20:254-259
30. Cholet-Martin S, Gatecel C, Kerrmarrec N, Gougerot-Pocidalo MA, Payen DM (1996) Alveolar neutrophil functions and cytokine levels in patients with adult respiratory distress syndrome during nitric oxide inhalation. Am J Resp Crit Care Med 153:985-990
31. Skimming JW, Cassin S, Blanch PB (1995) Nitric oxide administration using constant-flow ventilation. Chest 108:1065-1072
32. Zapol WM, Rimar S, Gillis N, Bosken CH (1994) Nitric oxide and the lung. Am J Respir Crit Care Med 149:1375-1380
33. Moutafis M, Hatahet Z, Castelain MH, Renaudin MH, Monnot A, Fischler M (1995) Validation of a simple method assessing nitric oxide and nitrogen dioxide concentrations. Intensive Care Med 21:537-541
34. Lu Q, Mourgeon E, Law-Koune JD, Roche S, Vézinet C, Abdenour L, Vicaut E, Puybasset L, Diaby M, Coriat P, Rouby JJ (1995) Dose-response of inhaled NO with and without intravenous almitrine in adult respiratory distress syndrome. Anesthesiology 83:929-943
35. Bauer MA, Utell MJ, Morrow PE, Speers DM, Gibb FR (1986) Inhalation of 0.30 ppm nitrogen dioxide potentiates exercice-induced bronchospasm in asthmatics. Am Rev Resp Dis 134:1203-1208
36. 3. Am J Resp Crit Care Med 150:642-647
37. Sandström T, Stjernberg N, Eklund A, Ledin M-C, Bjermer L, Kolmodin-Hedman B, Lindström K, Rosenhall L, Angström T (1991) Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study. Eur Respir J 3:332-339
38. Wennmaln A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Nathorst Westfelt U, Petersson A, Waagstein F (1993) Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73:1121-1127
39. Young JD, Dyar O, Xiong L, Howell S (1994) Methaemoglobin production in normal adults inhaling low concentrations of nitric oxide. Intensive Care Med 20:581-584
40. Isomura K, Chikahira M, Terashini K, Hamada K (1984) Induction of mutations and chromosome aberrations in lung cells following in vivo exposures to nitrogen oxides. Mutation Research 136:119-125
41. Arroyo PL, Hatch-Pigott V, Mower HF, Cooney RV (1992) Mutagenecity of nitric oxide and its inhibition by antioxidants. Mutation Research 281:193-202
42. Nguyen T, Brunson D, Crospi CL, Penman BW, Wishnok JS, Tannenbaum SR (1992) DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci 89:3030-3034
43. Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, Cebula TA, Koch WH, Andrews AW, Allen JS, Keefer LK (1991) DNA deaminating ability and geno-toxicity of nitric oxide and its pro-genitors. Science 254:1001-1003
44. Beckman JS, Beckman TW, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci 87:1620-1624
45. Haddad LY, Crow JP, Yaozu Y, Beckman J, Matalon S (1994) Concurrent generation of nitric oxide and superoxide damages surfactant protein A (SP-A). Am J Resp Crit Care Med Suppl 149:A549 (Abstract)
46. Greenbaum R, Bay J, Hargreaves MD, Kain ML, Kelman GR, Nunn JF, Prys-Roberts C, Siebold K (1967) Effects of higher oxides of nitrogen in the anaesthetized dog. Br J Anaesth 39:393-404
47. Oda H, Nogami H, Kusumotos S, Nakajima T, Kurata A, Imai K (1976) Long-term exposure to nitric oxide in mice. J Jpn Soc Air Pollut 11:150-160
48. Oda H, Nogami H, Kusumoto S, Nakajima T, Kurata A (1980) Lifetime exposure to 2.4 ppm nitric oxide in mice. Env Research 22:254-263
49. Mercer R, Costa D, Crapo J (1995) Effects of prolonged exposure to low doses of nitric oxide or nitrogen dioxide on the alveolar septa of the adult rat. Laboratory Investigation 73:20-28
50. Gessler P, Nebe T, Birle A, Mueller W, Kachel W (1996) A new side effect of inhaled nitric oxide in neonates and infants with pulmonary hypertension: functional impairement of the neutrophil respiratory burst. Intensive Care Med 22:252-258
51. Foubert L, Fleming B, Latimer R, Jonas M, Oduro A, Borland C, Higenbottam T (1992) Safety guidelines for use of nitric oxide. Lancet 339:1615-1616
52. Westfelt U, Lundin S, Stenqvist O (1996) Safety aspects of delivery and monitoring of nitric oxide during mechanical ventilation. Acta Anaesthesiol Scand. 40:302-310
53. Man SFP, Williams DJ, Amy GC, Man GCW, Lien DC (1990) Sequential changes in canine pulmonary epithelial and endothelial cell functions after nitrogen dioxide. Am Rev Resp Dis 142:199-205
54. Ranga V, Kleinerman J, Ip MPC, Collins AM (1980) The effect of nitrogen dioxide on tracheal uptake and transport of horseradish peroxidase in the guinea pig. Am Rev Resp Dis 122:483-490
55. Guth DJ, Mavis RD (1985) Biochemical assessment of acute nitrogen dioxide toxicity in rat lung. Toxicol Appl Pharmacol 81:128-138
56. Stavert DM, Lehnert BE (1990) Nitrogen oxide and nitrogen dioxide as inducers of acute pulmonary injury when inhaled at relatively highs concentrations for brief periods. Inhal Toxicol 2:53-57
57. Ben-Jebria A, Marthan R, Savineau JP (1992) Effect of in vitro nitrogen dioxide exposure on human bronchial smooth muscle response. Am Rev Respir Dis 146:378-382
58. Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ (1991) Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am Rev Resp Dis 143:522-527
59. Rose RM, Fuglestad JM, Skornik WA, Hammer SM, Wolfhal SF, Beck BD, Brain JD (1988) The pathophysiology of enhanced susceptibility to murine cytomegalovirus respiratory infection during short-term exposure to 5 ppm nitrogen dioxide. Am Rev Resp Dis 137:912-917
60. 1 and nitroglycerin reduce pulmonary capillary pressure but worsen ventilation-perfusion distributions in patients with adult respiratory distress syndrome. Anesthesiology 70:601-606
61. Radermacher P, Santak B, Wüst HJ, Tarnow J, Falke KJ (1990) Prostacyclin for the treatment of pulmonary hypertension in patients with acute respiratory distress syndrome: Effects on pulmonary capillary pressure and ventilation-perfusion distributions. Anesthesiology 72:238-244
62. Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA (1994) Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035-2040
63. Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM (1993) Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78:427-435
64. Puybasset L, Rouby JJ, Mourgeon E, Cluzel P, Law-Koune JD, Stewart T, Devilliers C, Lu Q, Roche S, Kalfon P, Vicaut E, Viars P (1995) Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure. Am J Resp Crit Care Med 152:318-328
65. Langleben D, Demarchie M, Laporta D, Spanier AH, Schlesinger RD, Stewart DJ (1993) Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Resp Dis 148:1646-1650
66. Zapol WM, Snider MT, Rie MA, Quinn DA, Frikker M (1985) Pulmonary circulation during adult respiratory distress syndrome. In: Zapol WM and Falke KJ (ed). Acute respiratory failure. New York: Dekker, Inc. 209-226
67. Fierobe L, Brunet F, Dhainaut JF, Monchi M, Belghit M, Mira JP, Dall'ava-Santucci J, Dinh-Xuan AT (1995) Effect of inhaled nitric oxide on right ventricular function in adult respiratory distress syndrome. Am J Resp Crit Care Med 151:1414-1419
68. Rossaint R, Slama K, Steudel W, Gerlach H, Pappert D, Veit S, Falke K (1995) Effects of inhaled nitric oxide on right ventricular function in severe acute respiratory distress syndrome. Intensive Care Med 21:197-203
69. Kurrek MM, Castillo L, Bloch KD, Tannenbaum SR, Zapol WM (1995) Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion. J Appl Physiol 79:1088-1092
70. Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M (1987) Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am Rev Resp Dis 136:730-736
71. Krafft P, Fridrich P, Fitzgerald RD, Koc D, Stelzer H (1996) Effectiveness of nitric oxide inhalation in septic ARDS. Chest 109:486-493
72. Loh E, Stamler JS, Hare JM, Loscalzo J, Colucci WS (1994) Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation 90:2780-2785
73. Bocchi EA, Bacal F, Costa Auter JO, De Carvalho C, Bellotti G, Pileggi F (1994) Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 70-72
74. Kieler-Jensen N, Ricksten SE, Stenqvist O, Berg CH, Lindelov B, Wennmalm A, Waagstein F, Lundin S (1994) Inhaled nitric oxide in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance. J Heart Lung Transplant 13:366-375
75. Semigran RCS, Cockrill BA, Kacmarek R, Thompson T, Zapol WM, Dec W, Fifer A (1994) Hemodynamic effects of inhaled nitric oxide in patients with left ventricular dysfunction. J Am Coll Cardiol 24:982-988
76. Koizumi T, Gupta R, Banerjee M, Newman JH (1994) Changes in pulmonary vascular tone during exercise. Effects of nitric oxide synthase inhibition, L-arginine infusion and NO inhalation. J Clin Invest 94:2275-2282
77. Lindeborg DM, Kavanagh BP, Van Meurs K, Pearl RG (1995) Inhaled nitric oxide does not alter the longitudinal distribution of pulmonary vascular resistance. J Appl Physiol 78:341-348
78. Benzing A, Geiger K (1994) Inhaled nitric oxide lowers pulmonary capillary pressure and changes longitudinal distribution of pulmonary vascular resistance in patients with acute lung injury. Acta Anaesthesiol Scand 38:640
79. Jones R, Langleben D, Reid LM (1991) Patterns and mechanisms of remodeling of the pulmonary circulation in acute and subacute lung injury. In: Said SI (ed). The pulmonary circulation and acute lung injury. Mount Kisko, NY: Futura Publishing Company, Inc, 179-242
80. Scott-Burden T, Vanhoutte PM (1993) The endothelium as a regulator of vascular smooth proliferation. Circulation 87 (Suppl V):V51-V55
81. Roberts JD, Roberts CT, Jones RC, Zapol WM, Bloch KD (1995) Continuous nitric oxide inhalation reduces pulmonary structural changes, right ventricular hypertrophy and growth retardation in the hypoxic newborn rat. Circ Res 76:215-222
82. Putensen C, Räsänen J, Lopez FA, Downs JB (1994) Continuous positive airway pressure modulates effect of inhaled nitric oxide on the ventilation-perfusion distribution in canine lung injury. Chest 106:1563-1569
83. Fellahi JL, Mourgeon E, Goarin JP, Law-Koune JD, Riou B, Coriat P, Rouby JJ (1995) Inhaled nitric oxide-induced closure of a patent foramen avale in a patient with adult respiratory distress syndrome and life-threatening hypoxemia. Anesthesiology 83:635-638
84. Hagen PT, Scholz DG, Edwards WD (1984) Incidence and size of patent foramen ovale during first decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc 59:17-20
85. Estagnasié P, Le Bourdeles G, Mier L, Coste F, Dreyfuss D (1994) Use of inhaled nitric oxide to reverse flow through a patent foramen ovale during pulmonary embolism. Ann Intern Med 120:757-759
86. Stewart TE, Rouby JJ, Puybasset L, Mourgeon E, Descouls AM, Viars P (1994) Inhaled NO reduces alveolar dead space in patients with ARDS and pulmonary hypertension. Am J Resp Crit Care Med Suppl 149:A424 (Abstract)
87. Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM (1992) Bronchodilator action of inhaled nitric oxyde in guinea pigs. J Clin Invest 90:421-428
88. Hogman M, Frostell CG, Arnberg H, Hedenstierna G (1993) Inhalation of nitric oxide modulates metacholine induced bronchoconstriction in the rabbit. Eur Respir J 6:177-180
89. Puybasset L, Mourgeon E, Segal E, Bodin L, Rouby JJ, Viars P (1993) Effects of inhaled nitric oxide on respiratory resistance in patients with ARDS. Anesthesiology 79 (suppl 3A): A299 (Abstract)
90. Law-Koune JD, Roche S, Mourgeon E, Lu Q, Puybasset L, Kalfon P, Rouby JJ, Viars P (1994) Acute toxicity of inhaled NO in ARDS. Anesthesiology 81 (suppl 3A):A263 (Abstract)
91. Högman M, Frostell CG, Hedenström H, Hedenstierna G (1993) Inhalation of nitric oxide modulates adult bronchial tone. Am Rev Resp Dis 148:1474-1478
92. Heffner JE, Sahn SA, Repine JE (1987) The role of platelets in the adult respiratory distress syndrome. Culprits or bystander? Am J Resp Crit Care Med 135:482-492
93. Loscalzo J (1992) Antiplatelet and antithrombotic effect of organic nitrates. Am J Cardiol 70:18B-22B
94. Radomski MW, Moncada S (1993) Regulation of vascular homeostasis by nitric oxide. Thromb Haemost 70:36-41
95. Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ (1981) Evidence for the inhibitory role of guanosine 3í5í monophosphate in ADP induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 57:946-955
96. Salvemini D, Radziszewski W, Korbut R, Vane J (1990) The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors. Br J Pharmacol 101:991-995
97. Furchgott RF (1988) Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that acid-activatable inhibitory factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In: Vanhoutte PM (ed). Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves and Endothelium. New York: Raven Press, 401-414
98. Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, Guillosson JJ, Coriat P, Rouby JJ (1995) Inhibition of platelet aggregation by inhaled nitric oxide in patients with adult respiratory distress syndrome. Anesthesiology 83:56-65
99. Umamaheswara Rao GS, Lu Q, Diaby M, Mourgeon E, Law-Koune J, Frappier J, Arock M, Samama CM, Coriat P, Rouby J (1996) Inhibition of platelet aggregation by inhaled nitric oxide in ARDS patients - a dose-effect study (abstract). Br J Anaesth 76 (suppl 2):112, A 360
100. Högman M, Frostell CG, Arnberg H, Sandhagen B, Hedenstierna G (1994) Prolonged bleeding time during NO inhalation in the rabbit. Acta Physiol Scand 151:125-129
101. Högman M, Frostell CG, Arnberg H, Hedenstierna G (1993) Bleeding time prolongation and NO inhalation. Lancet 341:1664-1665
102. Rodgers C, Levin J (1990) A critical reappraisal of the bleeding time. Semin Thromb Hemost 16:1-20
103. Golino P, Capelli-Bigazzi E, Ambrosio G, Ragni M, Russolillo E, Candorelli M, Chiarello M (1992) Endothelium-derived relaxing factor modulates platelet aggregation in an in vivo model of reccurent platelet activation. Circ Res 71:1447-1456
104. Yao SK, Ober JC, Krishnaswami A, Ferguson JJ, Anderson HV, Golino P, Buja LM, Willerson JT (1992) Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Circulation 86:1302-1309
105. Folts JD (1991) An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis. Circulation 83: S IV:4-14
106. Malmros C, Blomquist S, Dahm P, Martensson L, Thörne J (1996) Nitric oxide inhalation decreases pulmonary platelet and neutrophil sequestration during extracorporeal circulation in pig. Crit Care Med 24:845-849
107. Blomquist H, Wickert CJ, Andreen M. Ullergberg U, Ortquist A, Frostell C (1993) Enhanced pneumonia resolution by inhalation of Nitric Oxide. Acta Anaesthesiol Scand 37:110-114
108. Benzing A, Brautigam P, Geiger K, Loop T, Beyer U, Moser E (1995) Inhaled nitric oxide reduces pulmonary transvascular albumin flux in patients with acute lung injury. Anesthesiology 83:1153-1161
109. Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo cyclic guanosine monophosphate inhibit mitogenesis and prolife-ration of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774-1777
110. Lee JS, Adrie C, Jacob HJ, Roberts JDJ, Zapol WM, Bloch KD (1996) Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res 78:337-342
111. Rimar S, Gillis CN (1992) Pulmonary vasodilation by inhaled nitric oxide after endothelial injury. J Appl Physiol 73:2179-2183
112. White CW, Nguyen DH, Tuder R (1994) Nitric oxide modulation of hyperoxic injury. Am J Resp Crit Care Med Suppl 149:A548 (Abstract)
113. Berisha H, Pakbaz H, Absood A, Said SI (1994) Excess nitric oxide (NO) production in acute lung injury: role of constitutive vs inducible NO synthase. Am J Resp Crit Care Med 149:A552
114. Rovira I, Chen TY, Winkler M, Kawai N, Bloch KD, Zapol WM (1994) Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol 76:345-355
115. Rich FR, Roos CM, Anderson SM, Urich DC, Daugherty MO, Johns RA (1993) Inhaled nitric oxide: dose response and the effects of blood in the isolated rat lung. J Appl Physiol 75:1278-1284
116. Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ (1993) Long-term inhalation with evaluated low doses of nitric oxide for selective improvement in oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 19.443-449
117. Lowson S, Rich G, McArdle P, Jaidev J, Morris G (1996) The response to varying concentrations of inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesth Analg 82:574-581
118. Gerlach H, Rossaint R, Pappert D, Falke KJ (1993) Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23:499-502
119. Mourgeon E, Law-koune JD, Lu Q, Roche S, Puybasset L, Diaby M, Rouby JJ, Viars P (1995) Inhaled NO in ARDS with and without septic shock: dose-response curves. Br J Anaesth 74 (suppl 1):A411 (Abstract)
120. Journois D, Pouard P, Mauriat P, Malhère T, Vouhé P, Safran D (1994) Inhaled nitric oxide as a therapy for pulmonary hypertension after operations for congenital defects. J Thorac CardioVasc Surg 107:1129-1135
121. Sellden H, Winberg P, Gustafsson LE, Lundell BO, Book K, Frostell CG (1993) Inhalation of nitric oxide reduced pulmonary hypertension after cardiac surgery in a 3.2 kg infant. Anesthesiology 78:577-580
122. Tiner NN, Etches RC, Kamstra B, Tierney AJ, Peliowski A, Ryan A (1994) Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation : dose-response. J Pediatr 124:302-308
123. Day RW, Guarin M, Lynch JM, Vernon DD, Dean JM (1996) Inhaled nitric oxide in children with severe lung disease: Results of acute and prolonged therapy with two concentrations. Crit Care Med 24:215-221
124. Pappert D, Busch T, Gerlach H, Lewandowski K, Radermacher P, Rossaint R (1995) Aerosolized prostacyclin versus inhaled nitric oxide in children with severe acute respiratory distress syndrome. Anesthesiology 82:1507-1511
125. Walmrath D, Schneider T, Pilch J, Grimminger F, Seeger W (1993) Aerosolized prostacyclin reduces pulmonary artery pressure and improves gas exchange in adult respiratory distress syndrome. Lancet 342:961-962
126. Walmrath D, Schneider T, Pilch J, Schermuly R, Grimminger F, Seeger W (1995) Effects of aerosolized prostacyclin in severe pneumonia - Impact of fibrosis. Am J Resp Crit Care Med 151:724-730
127. Zwissler B, Rank N, Jaenicke U, Schürle B, Welte M, Reichart B, Netz H, Messmer K, Peter K (1995) Selective pulmonary vasodilation by inhaled prostacyclin in a newborn with congenital heart disease and cardiopulmonary bypass. Anesthesiology 82:1512-1516
128. 1: molecular mechanisms and therapeutic utility. Prog Hemostasis Thrombosis 10:307-337
129. Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W (1996) Direct comparison of inhaled nitric oxide and aerosolised prostacyclin in acute respiratory distress syndrome. Am J Resp Crit Care Med 153:991-996
130. 2α by inhalation. Adv Prostaglandin Thromboxane Res 7:943-951
131. Weite M, Zwissler B, Habler O, Kleen M, Messmer K (1995) Prostacyclin aerosol and inhaled nitric oxide fail to reverse pulmonary vasoconstriction induced by thromboxane analogue in dogs. Acta Physiol Scand 154:395-405
132. Reyes A, Roca J, Rodriguez-Roisin R, Torres A, Ussetti P, Wagner PD (1988) Effect of almitrine on ventilation-perfusion distribution in adult respiratory distress syndrome. Am Rev Resp Dis 137:1062-1067
133. Naeije R, Melot C, Mois P (1981) Effects of almitrine in decompensated chronic respiratory insufficiency. Bull Eur Physiopath Respir 17:153-161
134. Dreyfuss D, Djedaini K, Lanore JJ, Mier L, Froidevaux R, Coste F (1992) A comparative study of the effects of almitrine bismesylate and lateral position during unilateral bacterial pneumonia with severe hypoxemia. Am Rev Resp Dis 146:295-299
135. Leeman M, Delcroix M, Vachiery JL, Mélot C, Naeije R (1992) Almitrine and doxapram in experimental lung injury. Am Rev Resp Dis 145:1042-1046
136. Chen L, Miller FL, Malmkvist G, Clergue F, Marschall C, Marschall BE (1987) High-dose almitrine bismesylate inhibits hypoxic pulmonary vasoconstriction in closed chest dogs. Anesthesiology 67:534-542
137. Naeije R, Lejeune P, Vachiery JL, Leeman M, Mélot C, Hallemens R, Delcroix M, Brimioulle S (1990) Restored hypoxic pulmonary vasoconstriction by peripheral chemoreceptor agonists in dogs. Am Rev Resp Dis 142:789-795
138. Gottshall EB, Fernyak S, Wuertemberger G, Voelkel AF (1992) Almitrine mimics hypoxic vasoconstriction in isolated rat lungs. Am J Physiol 263:383-391
139. Leeman M (1991) The pulmonary circulation in acute lung injury: a review of some recent advances. Intensive Care Med 17:254-260
140. Payen D, Gatecel C, Plaisance P (1993) Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome. Lancet 341:1664
141. Roche S, Lu Q, Law-Koune JD, Puybasset L, Mourgeon E, Dreux S, Kalfon P, Rouby JJ, Viars JJ (1994) Effects of combining inhaled NO and intravenous almitrine in patients with ARDS. Anesthesiology 81.A264 (Abstract)
142. Gallart L, Umamaheswara Rao G, Law-Koune J, Abdenour L, Lu Q, Puybasset L, Coriat P, Rouby J (1996) Almitrine alone or in combination with inhaled nitric oxide: dose-response curves in patients with ARDS (abstract). Br J Anaesth 76 (suppl 2): 114 A367
143. Bromet N, Singlas E (1984) Pharmacocinétique clinique du bismésylate d'almitrine. Presse Médicale 13:2071-2077
144. Aubert Y, Baune A, Courbe S, Guillaudeux J, Bromet N (1982) Pharmacocinétique du bismésilate d'almitrine chez l'homme. Bull Physiop Resp 18 (suppl 4):307-314
145. Tweeny J, Evans TW, Waterhouse JC, Nicoll J, Suggett AJ, Howard P (1985) Long term oxygen therapy and almitrine bismesylate. In: Allegra L and Rizzato G (ed). Bronchitis and emphysema. A171
146. Stradling JR, Barnes P, Pride NB (1982) The effects of almitrine on the ventilatory response to hypoxia and hypercapnia in normal subjects. Clin Sci 63:401-404
147. Wounters EFM, Greve LH, Steenhuis ES, Gimeno F (1988) Almitrine and peripheral neuropathy. Lancet ii:336
148. McLeed CM, Thomas RW, Bartley EA, Parkhurst GW, Bachaud RT (1983) Effect of handling of almitrine bismesylate in healthy subjects. Eur J Respir Dis 64:275-289
149. Bouche P, Lacomblez L, Leger JM, Chaunu MP, Ratinatirana H, Brunet P, Hauw JJ, Laplane D (1989) Peripheral neuropathies during treatment with almitrine: report of 46 cases. J Neurol 236:29-33
150. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, Stoclet JC (1990) Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 259 (Heart Circ Physiol 28):H1038-H1043
151. Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T (1994) Induction of cyclo-oxygenase-2 by interleukin-1 alpha. J Biol Chem 269:11769-11775
152. 2 synthase (cyclo-oxygenase) in human monocytes. J Biol Chem 265:16737-16740
153. Maier JAM, Hla T, Maciag T (1990) Cyclo-oxygenase is an immediate-early gene induced by interleukin-1 in human endothelail cells. J Biol Chem 265:10805-10808
154. Pritchard KA, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB (1994) Induction of cyclo-oxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Biol Chem 269:8504-8509
155. Liu S. Crawley DE, Barnes PJ, Evans TW (1991) Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Resp Dis 143:32-37
156. Leeman M, de Beyl VZ, Delcroix M, Naeije R (1994) Effects of endogenous nitric oxide on pulmonary vascular tone in intact dogs. Am J Physiol 266 (Heart Circ Physiol. 35): H2343-H2347
157. Sprague RS, Thiemermann C, Vane JR (1992) Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proc Natl Acad Sci 89:8711-8715
158. Putensen C, Räsänen J, Downs JB (1994) Effect of endogenous and inhaled nitric oxide on the ventilation-perfusion relationships in oleic-acid lung injury. Am J Resp Crit Care Med 150:330-336
159. Lorente JA, Landin L, de Pablo R, Renes E, Liste D (1993) L-arginine pathway in the sepsis syndrome. Crit Care Med 21:1287-1295
160. Brimioulle S, Lejeune P, Vachiéry JL, Delcroix M, Hallemans R, Leeman M, Naeije R (1994) Stimulus-response curve of hypoxic pulmonary vasoconstriction in intact dogs: effects of ASA. Am J Physiol 77:476-480
161. Leeman M, Lejeune P, Hallemans R, Mélot C, Naeije R (1988) Effects of increased pulmonary vascular tone on gas exchange in canine oleic acid pulmonary edema. J Appl Physiol 65:662-668
162. Leeman M, Delcroix M, Vachiéry JL, Mélot C, Naeije R (1992) Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclo-oxygenase inhibitors. J Appl Physiol 72:251-258
163. Schulman LL, Lennon PF, Ratner SJ, Enson Y (1988) Meclofenamate enhances blood oxygenation in acute oleic acid lung injury. J Appl Physiol 64:710-718
164. Hales CA, Peterson M, Kong D, Miller M, Watkins WD (1981) Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs. J Clin Invest 68:497-505
165. Graham LM, Vasil A, Vasil ML, Voelkel NF, Stenmark KR (1990) Decreased pulmonary vasoreactivity in an animal model of chronic pseudomonas pneumonia. Am Rev Resp Dis 142:221-229
166. Schuster DP, Sandiford P, Stephenson AH (1993) Thromboxane receptor stimulation:inhibition and perfusion redistribution after acute lung injury. J Appl Physiol 75:2069-2078
167. Janssens SP, Musto SW, Hutchinson WG, Spence C, Witten M, Jung W, Hales CA (1994) Cyclooxygenase and lipooxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. J Appl Physiol 77:888-895
168. Hanly PJ, Roberts D, Dobson K, Light RB (1987) Effect of indomethacin on arterial oxygenation in critically ill patients with severe bacterial pneumonia. Lancet i:351-354
169. Steinberg SM, Rodriguez JL, Bitzer LG, Kelley KA, Flint LM (1990) Indomethacin treatment of human adult respiratory distress syndrome. Circ Shock 30:375-384