Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)

Hormone and Metabolic Research

Volumn 29, Issue 2, 1997, Pages 56-59

  Yamato, E ^a   Ikegami, H ^a   Takekawa, K ^a   Fujisawa, T ^a   Nakagawa, Y ^a   Hamada, Y ^a   Ueda, H ^a   Ogihara, T ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

GLP 1 receptor gene; glucagon receptor gene; mouse insulinoma cell line; regulation by glucose; tissue distribution

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; GLUCOSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HISTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TISSUE SPECIFICITY;

EID: 0030996638     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978985     Document Type: Article

References (19)

1. Unger RH: Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 28: 574-578 (1985).
2. Mojsov S, Weir GC, Habener JF: Insulinotropin: glucagon-like peptide-1 (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79: 616-619 (1987).
3. Kreyman G, Ghatei MA, Williams G, Bloom SR: Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2: 1300-1304 (1987).
4. Gutniak M, ørskov C, Holst JJ, Ahrén B, Efendic S: Antidiabetogenic effect of glucagon-like peptide1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326: 1316-1322 (1992).
5. Mojsov S, Heinrich G, Wilson I, Ravazzola M, Orch L, Habener JF: Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261: 11880-11889 (1986).
6. Ørskov C, Holst JJ, Knuhtsen S, Baldissera FGA, Poulsen SS, Nielsen OV: Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475 (1986).
7. Jelinek LJ, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S, Bensch PA, Kuijper JL, Sheppard PO, Sprecher CA, O'Hara PJ, Foster D, Walker KM, Chen LHJC, McKernan PA, Kindsvogel W: Expression cloning and signaling properties of the rat glucagon receptor. Science 259: 1614-1616 (1993).
8. Svoboda M, Ciccarelli E, Tastenoy M, Robberecht P, Christophe J: cDNA construct allowing the expression of rat hepatic glucagon receptors. Biochem Biophys Res Comm 192: 135-142 (1993).
9. Thorens B: Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U.S.A. 89: 8641-8645 (1992).
10. Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo Warren H, Permutt MA, Boyd AED: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology 133: 1907-1910 (1993).
11. Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C: Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42: 1678-1682 (1993).
12. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K: Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132 (1990).
13. Yamato E, Ikegami H, Tahara Y, Fukuda M, Cha T, Kawaguchi Y, Fujioka Y, Noma Y, Shima K, Ogihara T: Glyburide enhances insulin gene expression and glucose-induced insulin release in isolated rat islets. Biochem Biophys Res Comm 199: 327-333 (1994).
14. Svoboda M, Tastenoy M, Vertongen P, Robberecht P: Relative quantitative analysis of glucagon receptor mRNA in rat tissues. Mol Cell Endocrinol 105: 131-137 (1994).
15. Campos RV, Lee YC, Drucker DJ: Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology 134: 2156-2164 (1994).
16. Wei Y, Mojsov S: Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 358: 219-224 (1995).
17. Kawai K, Yokota C, Ohashi S, Watanabe Y, Yamashita K: Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia 38: 274-276 (1995).
18. Abrahamsen N, Nishimura E: Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3′,5′-monophosphate, and glucocorticoids. Endocrinology 136: 1572-1578 (1995).
19. Yamato E, Noma Y, Tahara Y, Ikegami H, Yamamoto Y, Cha T, Yoneda H, Ogihara T, Ohboshi C, Mirota M, Shima K: Suppression of synthesis and release of glucagon by glucagon-like peptide-1 (7-36 amide) without affect on mRNA level in isolated rat islets. Biochem Biophys Res Comm 167: 431-437 (1990).