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Volumn 78, Issue 5, 1997, Pages 999-1006

Modulation of primary human immunodeficiency virus type 1 envelope glycoprotein-mediated entry by human antibodies

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; MONOCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

EID: 0030995840     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-5-999     Document Type: Article
Times cited : (14)

References (45)
  • 1
    • 0026434572 scopus 로고
    • Receptor-mediated activation of immunodeficiency viruses in viral fusion
    • Allan, J. S. (1991). Receptor-mediated activation of immunodeficiency viruses in viral fusion. Science 252, 1322-1323.
    • (1991) Science , vol.252 , pp. 1322-1323
    • Allan, J.S.1
  • 3
    • 0027297763 scopus 로고
    • Both the V2 and V3 regions of the human immunodeficiency virus type 1 surface glycoprotein functionally interact with other envelope regions in syncytium formation
    • Andeweg, A. C., Leeflang, P., Osterhaus, A. D. M. E. & Bosch, M. L. (1993). Both the V2 and V3 regions of the human immunodeficiency virus type 1 surface glycoprotein functionally interact with other envelope regions in syncytium formation. Journal of Virology 67, 3232-3239.
    • (1993) Journal of Virology , vol.67 , pp. 3232-3239
    • Andeweg, A.C.1    Leeflang, P.2    Osterhaus, A.D.M.E.3    Bosch, M.L.4
  • 6
    • 0024581896 scopus 로고
    • Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells
    • Clapham, P. R., Weber, J. N., Whitby, D., Mcintosh, K., Dalgleish, A. G., Maddon, P. J., Deen, K. C., Sweet, R. W. & Weiss, R. A. (1989). Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature 337, 368-370.
    • (1989) Nature , vol.337 , pp. 368-370
    • Clapham, P.R.1    Weber, J.N.2    Whitby, D.3    Mcintosh, K.4    Dalgleish, A.G.5    Maddon, P.J.6    Deen, K.C.7    Sweet, R.W.8    Weiss, R.A.9
  • 7
    • 0026656502 scopus 로고
    • Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: Induction and enhancement by soluble CD4
    • Clapham, P. R., McKnight, A. & Weiss, R. A. (1992). Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4. Journal of Virology 66, 3531-3537.
    • (1992) Journal of Virology , vol.66 , pp. 3531-3537
    • Clapham, P.R.1    McKnight, A.2    Weiss, R.A.3
  • 8
    • 0026501677 scopus 로고
    • Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity
    • de Jong, J. J., Goudsmit, J., Keulen, W., Klaver, B., Krone, W., Tersmette, M. & de Ronde, A. (1992). Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. Journal of Virology 66, 757-765.
    • (1992) Journal of Virology , vol.66 , pp. 757-765
    • De Jong, J.J.1    Goudsmit, J.2    Keulen, W.3    Klaver, B.4    Krone, W.5    Tersmette, M.6    De Ronde, A.7
  • 10
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G. & Doms, R. W. (1996). A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85, 1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3    Smyth, R.J.4    Samson, M.5    Peiper, S.C.6    Parmentier, M.7    Collman, R.G.8    Doms, R.W.9
  • 11
    • 0027975512 scopus 로고
    • An anti-gp41 human monoclonal antibody that enhances HIV-1 infection in the absence of complement
    • Eaton, A. M., Ugen, K. E., Weiner, D. B., Wildes, T. & Levy, J. A. (1994). An anti-gp41 human monoclonal antibody that enhances HIV-1 infection in the absence of complement. AIDS Research and Human Retroviruses 10, 13-18.
    • (1994) AIDS Research and Human Retroviruses , vol.10 , pp. 13-18
    • Eaton, A.M.1    Ugen, K.E.2    Weiner, D.B.3    Wildes, T.4    Levy, J.A.5
  • 12
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 13
    • 0019351935 scopus 로고
    • SV40-transformed simian cells support the replication of early SV40 mutants
    • Gluzman, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23, 175-182.
    • (1981) Cell , vol.23 , pp. 175-182
    • Gluzman, Y.1
  • 14
    • 0027311936 scopus 로고
    • Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HTV-1 gp120
    • Gorny, M. K., Xu, J. Y., Karwowska, S., Buchbinder, A. & Zolla-Pazner, S. (1993). Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HTV-1 gp120. Journal of Immunology 150, 635-643.
    • (1993) Journal of Immunology , vol.150 , pp. 635-643
    • Gorny, M.K.1    Xu, J.Y.2    Karwowska, S.3    Buchbinder, A.4    Zolla-Pazner, S.5
  • 15
    • 0026640859 scopus 로고
    • Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: Evidence for in vivo recombination and determinants of cytotropism outside the V3 domain
    • Groenink, M., Andeweg, A. C., Fouehier, R. A. M., Broersen, S., van der Jagt, R. C., Schuitemaker, H., de Goede, R. E. Y., Bosch, M. L., Huisman, H. G. & Tersmette, M. (1992). Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain. Journal of Virology 66, 6175-6180.
    • (1992) Journal of Virology , vol.66 , pp. 6175-6180
    • Groenink, M.1    Andeweg, A.C.2    Fouehier, R.A.M.3    Broersen, S.4    Van Der Jagt, R.C.5    Schuitemaker, H.6    De Goede, R.E.Y.7    Bosch, M.L.8    Huisman, H.G.9    Tersmette, M.10
  • 16
    • 0025268873 scopus 로고
    • Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants
    • Helseth, E., Kowalski, M., Gabuzda, D., Olshevsky, U., Haseltine, W. & Sodroski, J. (1990). Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants. Journal of Virology 64, 2416-2420.
    • (1990) Journal of Virology , vol.64 , pp. 2416-2420
    • Helseth, E.1    Kowalski, M.2    Gabuzda, D.3    Olshevsky, U.4    Haseltine, W.5    Sodroski, J.6
  • 18
    • 0029655566 scopus 로고    scopus 로고
    • Quantitative analysis of serum neutralization of human immunodeficiency virus type 1 from subtypes A, B, C, D, E, F, and I: Lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent infectivity enhancement
    • Kostrikis, L. G., Cao, Y., Ngai, H., Moore, J. P. & Ho, D. D. (1996). Quantitative analysis of serum neutralization of human immunodeficiency virus type 1 from subtypes A, B, C, D, E, F, and I: lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent infectivity enhancement. Journal of Virology 70, 445-458.
    • (1996) Journal of Virology , vol.70 , pp. 445-458
    • Kostrikis, L.G.1    Cao, Y.2    Ngai, H.3    Moore, J.P.4    Ho, D.D.5
  • 19
    • 0023028190 scopus 로고
    • The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
    • Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A. & Axel, R. (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348.
    • (1986) Cell , vol.47 , pp. 333-348
    • Maddon, P.J.1    Dalgleish, A.G.2    McDougal, J.S.3    Clapham, P.R.4    Weiss, R.A.5    Axel, R.6
  • 20
    • 0028230502 scopus 로고
    • Analysis of the human immunodeficiency virus type 1 envelope protein interaction with the CD4 host cell receptor
    • Malvoisin, E. & Wild, F. (1994). Analysis of the human immunodeficiency virus type 1 envelope protein interaction with the CD4 host cell receptor. Journal of General Virology 75, 839-847.
    • (1994) Journal of General Virology , vol.75 , pp. 839-847
    • Malvoisin, E.1    Wild, F.2
  • 21
    • 0025259509 scopus 로고
    • Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4
    • Moore, J. P. (1990). Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4. AIDS 4, 297-305.
    • (1990) AIDS , vol.4 , pp. 297-305
    • Moore, J.P.1
  • 22
    • 0025572710 scopus 로고
    • Dissociation of gp120 from HIV-1 virions induced by soluble CD4
    • Moore, J. P., McKeating, J. A., Weiss, R. A. & Sattentau, Q. J. (1990). Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250, 1139-1142.
    • (1990) Science , vol.250 , pp. 1139-1142
    • Moore, J.P.1    McKeating, J.A.2    Weiss, R.A.3    Sattentau, Q.J.4
  • 23
    • 0026434572 scopus 로고
    • Receptor mediated activation of immunodeficiency viruses in viral fusion
    • Moore, J. P., McKeating, J. A., Weiss, R. A., Clapham, P. R. & Sattentau, Q. J. (1991). Receptor mediated activation of immunodeficiency viruses in viral fusion. Science 252, 1322-1323.
    • (1991) Science , vol.252 , pp. 1322-1323
    • Moore, J.P.1    McKeating, J.A.2    Weiss, R.A.3    Clapham, P.R.4    Sattentau, Q.J.5
  • 24
    • 0026601827 scopus 로고
    • Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates
    • Moore, J. P., McKeating, J. A., Huang, Y. X., Ashkenazi, A. & Ho, D. D. (1992). Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates. Journal of Virology 66, 235-243.
    • (1992) Journal of Virology , vol.66 , pp. 235-243
    • Moore, J.P.1    McKeating, J.A.2    Huang, Y.X.3    Ashkenazi, A.4    Ho, D.D.5
  • 25
    • 0028917784 scopus 로고
    • Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120
    • Moore, J. P., Cao, Y., Qing, L., Sattentau, Q. J., Pyati, J., Koduri, R., Robinson, J., Barbas, C. F., III, Burton, D. R. & Ho, D. D. (1995). Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120. Journal of Virology 69, 101-109.
    • (1995) Journal of Virology , vol.69 , pp. 101-109
    • Moore, J.P.1    Cao, Y.2    Qing, L.3    Sattentau, Q.J.4    Pyati, J.5    Koduri, R.6    Robinson, J.7    Barbas III, C.F.8    Burton, D.R.9    Ho, D.D.10
  • 27
    • 0027399209 scopus 로고
    • Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4
    • Orloff, S. L., Kennedy, M. S., Belperron, A. A., Maddon, P. J. & McDougal, J. S. (1993). Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4. Journal of Virology 67, 1461-1471.
    • (1993) Journal of Virology , vol.67 , pp. 1461-1471
    • Orloff, S.L.1    Kennedy, M.S.2    Belperron, A.A.3    Maddon, P.J.4    McDougal, J.S.5
  • 28
    • 0030023304 scopus 로고    scopus 로고
    • Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation
    • Poignard, P., Fouts, T., Naniche, D., Moore, J. P. & Sattentau, Q. J. (1996). Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation. Journal of Experimental Medicine 183, 473-484.
    • (1996) Journal of Experimental Medicine , vol.183 , pp. 473-484
    • Poignard, P.1    Fouts, T.2    Naniche, D.3    Moore, J.P.4    Sattentau, Q.J.5
  • 29
    • 0028291731 scopus 로고
    • Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1
    • Roben, P., Moore, J. P., Thali, M., Sodroski, J., Barbas, C. F., III & Burton, D. R. (1994). Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. Journal of Virology 68, 4821-4828.
    • (1994) Journal of Virology , vol.68 , pp. 4821-4828
    • Roben, P.1    Moore, J.P.2    Thali, M.3    Sodroski, J.4    Barbas III, C.F.5    Burton, D.R.6
  • 30
    • 0025359792 scopus 로고
    • Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors
    • Robinson, W. E., Jr, Montefiori, D. C. & Mitchell, W. M. (1990). Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors. Virology 175, 600-604.
    • (1990) Virology , vol.175 , pp. 600-604
    • Robinson Jr., W.E.1    Montefiori, D.C.2    Mitchell, W.M.3
  • 31
    • 0025866185 scopus 로고
    • Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding
    • Sattentau, Q. J. & Moore, J. P. (1991). Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. Journal of Experimental Medicine 174, 407-415.
    • (1991) Journal of Experimental Medicine , vol.174 , pp. 407-415
    • Sattentau, Q.J.1    Moore, J.P.2
  • 33
    • 0026600926 scopus 로고
    • Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations
    • Schuitemaker, H., Koot, M., Kootstra, N. A., Dercksen, M. W., de Goede, R. E. Y., van Steenwijk, R. P., Lange, J. M., Schattenkerk, J. K., Miedema, F. & Tersmette, F. (1992). Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations. Journal of Virology 66, 1354-1360.
    • (1992) Journal of Virology , vol.66 , pp. 1354-1360
    • Schuitemaker, H.1    Koot, M.2    Kootstra, N.A.3    Dercksen, M.W.4    De Goede, R.E.Y.5    Van Steenwijk, R.P.6    Lange, J.M.7    Schattenkerk, J.K.8    Miedema, F.9    Tersmette, F.10
  • 34
    • 0027290678 scopus 로고
    • Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies
    • Schutten, M., McKnight, A., Huisman, R. C., Thali, M., McKeating, J. A., Sodroski, J., Goudsmit, J. & Osterhaus, A. D. M. E. (1993). Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies. AIDS 7, 919-923.
    • (1993) AIDS , vol.7 , pp. 919-923
    • Schutten, M.1    McKnight, A.2    Huisman, R.C.3    Thali, M.4    McKeating, J.A.5    Sodroski, J.6    Goudsmit, J.7    Osterhaus, A.D.M.E.8
  • 35
    • 0028937182 scopus 로고
    • Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1
    • Schutten, M., Andeweg, A. C., Bosch, M. L. & Osterhaus, A. D. M. E. (1995 a). Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1. Scandinavian Journal of Immunology 41, 18-22.
    • (1995) Scandinavian Journal of Immunology , vol.41 , pp. 18-22
    • Schutten, M.1    Andeweg, A.C.2    Bosch, M.L.3    Osterhaus, A.D.M.E.4
  • 36
    • 0029027602 scopus 로고
    • Characterization of a V3 domain-specific neutralizing human monoclonal antibody that preferentially recognizes non-syncytium-inducing human immunodeficiency virus type 1 strains
    • Schutten, M., Langedijk, J. P. M., Andeweg, A. C., Huisman, R. C., Meloen, R. H. & Osterhaus, A. D. M. E. (1995 b). Characterization of a V3 domain-specific neutralizing human monoclonal antibody that preferentially recognizes non-syncytium-inducing human immunodeficiency virus type 1 strains. Journal of General Virology 76, 1665-1673.
    • (1995) Journal of General Virology , vol.76 , pp. 1665-1673
    • Schutten, M.1    Langedijk, J.P.M.2    Andeweg, A.C.3    Huisman, R.C.4    Meloen, R.H.5    Osterhaus, A.D.M.E.6
  • 37
    • 0029756585 scopus 로고    scopus 로고
    • Human antibodies that neutralize primary human immunodeficiency virus type 1 in vitro do not provide protection in an in vivo model
    • Schutten, M., Tenner-Racz, K., Racz, P., Van Bekkum, D. W. & Osterhaus, A. D. M. E. (1996). Human antibodies that neutralize primary human immunodeficiency virus type 1 in vitro do not provide protection in an in vivo model. Journal of General Virology 77, 1667-1675.
    • (1996) Journal of General Virology , vol.77 , pp. 1667-1675
    • Schutten, M.1    Tenner-Racz, K.2    Racz, P.3    Van Bekkum, D.W.4    Osterhaus, A.D.M.E.5
  • 38
    • 0023687042 scopus 로고
    • A simple phase extraction assay for chloramphenicol acetyltransferase activity
    • Seed, B. & Sheen, J. (1988). A simple phase extraction assay for chloramphenicol acetyltransferase activity. Gene 67, 271-277.
    • (1988) Gene , vol.67 , pp. 271-277
    • Seed, B.1    Sheen, J.2
  • 39
    • 0021719086 scopus 로고
    • Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines
    • Smith, S. D., Shatsky, M., Cohen, P. S., Warnke, R., Link, M. P. & Glader, B. E. (1984). Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines. Cancer Research 44, 5657-5660.
    • (1984) Cancer Research , vol.44 , pp. 5657-5660
    • Smith, S.D.1    Shatsky, M.2    Cohen, P.S.3    Warnke, R.4    Link, M.P.5    Glader, B.E.6
  • 40
    • 0023644926 scopus 로고
    • pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
    • Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G. & Engleman, E. G. (1987). pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell 49, 659-668.
    • (1987) Cell , vol.49 , pp. 659-668
    • Stein, B.S.1    Gowda, S.D.2    Lifson, J.D.3    Penhallow, R.C.4    Bensch, K.G.5    Engleman, E.G.6
  • 41
    • 0029020970 scopus 로고
    • Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
    • Sullivan, N., Sun, Y., Li, J., Hofmann, W. & Sodroski, J. (1995). Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. Journal of Virology 69, 4413-4422.
    • (1995) Journal of Virology , vol.69 , pp. 4413-4422
    • Sullivan, N.1    Sun, Y.2    Li, J.3    Hofmann, W.4    Sodroski, J.5
  • 43
    • 0025245831 scopus 로고
    • Soluble CD4 enhances simian immunodeficiency virus SIVagm infection
    • Werner, A., Winskowsky, G. & Kurth, R. (1990). Soluble CD4 enhances simian immunodeficiency virus SIVagm infection. Journal of Virology 64, 6252-6256.
    • (1990) Journal of Virology , vol.64 , pp. 6252-6256
    • Werner, A.1    Winskowsky, G.2    Kurth, R.3
  • 45
    • 0029039317 scopus 로고
    • Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry
    • Zolla-Pazner, S., O'Leary, J., Burda, S., Gorny, M. K., Kim, M., Mascola, J. & McCutchan, F. (1995). Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry. Journal of Virology 69, 3807-3815.
    • (1995) Journal of Virology , vol.69 , pp. 3807-3815
    • Zolla-Pazner, S.1    O'Leary, J.2    Burda, S.3    Gorny, M.K.4    Kim, M.5    Mascola, J.6    McCutchan, F.7


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