Identification in the rat neurotensin receptor of amino-acid residues critical for the binding of neurotensin

Molecular Brain Research

Volumn 46, Issue 1-2, 1997, Pages 311-317

  Botto, Jean Marie ^a   Chabry, Joëlle ^a   Nouel, Dominique ^b   Paquet, Michel ^b   Séguéla, Philippe ^b   Vincent, Jean Pierre ^a   Beaudet, Alain ^b   Mazella, Jean ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Binding; Charged amino acid; Mutagenesis; Neurotensin; Receptor

Indexed keywords

AMINO ACID; NEUROTENSIN; NEUROTENSIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; LIGAND BINDING; MUTAGENESIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; VESICULAR STOMATITIS VIRUS; XENOPUS LAEVIS;

AMINO ACIDS; ANIMALS; BRAIN; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MUTAGENESIS, SITE-DIRECTED; NEUROTENSIN; RADIOLIGAND ASSAY; RATS; RECEPTORS, NEUROTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030995335     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00006-5     Document Type: Article

References (19)

1. Baldwin, J.M., The probable arrangement of the helices in G protein-coupled receptors, EMBO J., 12 (1993) 1693-1703.
2. Bhogal, N., Donnelly, D. and Findlay, J.B.C., The ligand binding site of the neurokinin 2 receptor, J. Biol. Chem., 269 (1994) 27269-27274.
3. Chabry, J., Labbé-Jullié, C., Gully, D., Kitabgi, P., Vincent, J.P. and Mazella, J., Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms and internalization, J. Neurochem., 63 (1994) 19-27.
4. Chabry, J., Botto, J.M., Nouel, D., Beaudet, A., Vincent, J.P. and Mazella, J., Thr-422 and Tyr-424 residues in the carboxyl terminus are critical for the internalization of the rat neurotensin receptor, J. Biol. Chem., 270 (1995) 2439-2442.
5. Donnelly, D., Findlay, J.B.C. and Blundell, T.L., The evolution and structure of aminergic G protein-coupled receptors, Receptors Channels, 2 (1994) 61-78.
6. Fong, T.M., Huang, R.C. and Strader, C.D., Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor, J. Biol. Chem., 267 (1992) 25664-25667.
7. Kunkel, T.A., Rapid and efficient site-directed mutagenesis without phenotypic selection, Proc. Natl. Acad. Sci. USA, 82 (1985) 488-492.
8. Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M. and Nakanishi, S., cDNA cloning of bovine substance-K receptor trough oocyte expression system, Nature, 329 (1987) 836-838.
9. 11 neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity and binding properties to rat brain synaptic membranes, J. Biol. Chem., 258 (1983) 3476-3481.
10. Perlman, J.H., Nussenzveig, D.R., Osman, R. and Gershengorn, M.C., Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors, J. Biol. Chem., 267 (1992) 24413-24417.
11. Probst, W.C., Snyder, L.A., Schuster, D.I., Brosius, J. and Sealfon, S.C., Sequence alignment of the G protein-coupled receptor super-family, DNA Cell Biol., 11 (1992) 1-20.
12. Rosenkilde, M.M., Cahir, M., Gether, U., Hjorth, S.A. and Schwartz, T.W., Mutations along transmembrane segments II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding, J. Biol. Chem., 269 (1994) 28160-28164.
13. Sadoul, J.L., Mazella, J., Kitabgi, P. and Vincent, J.P., Preparation of neurotensin selectively iodinated on the tyrosine 3 residue. Biological activity and binding properties on mammalian neurotensin receptors, Biochem. Biophys. Res. Commun., 120 (1984) 812-819.
14. Sambrook, J., Fritsch, E.F. and Maniatis, T., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1989, pp. 13.42-13.77.
15. Strader, C.D., Sigal, I.S. and Dixon, R.A.F., Structural basis of β-adrenergic receptor function, FASEB J., 3 (1989) 1825-1832.
16. Strader, C.D., Fong, T.M., Tota, M.R., Underwood, D. and Dixon, R.A., Structure and function of G protein-coupled receptors, Annu. Rev. Biochem., 63 (1994) 101-132.
17. Tanaka, K., Masu, M. and Nakanishi, S., Structure and functional expression of the cloned rat neurotensin receptor, Neuron, 4 (1990) 847-854.
18. Vita, N., Laurent, P., Lefort, S., Chalon, P., Dumont, X., Kaghad, M., Gully, D., Le Fur, G., Ferrara, P. and Caput, D., Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor, FEBS Lett., 317 (1993) 139-142.
19. Xue, J.C, Chen, C., Zhu, J., Kunapuli, S., DeRiel, J.K., Yu, L. and Liu-Chen, L.Y., Differential binding domains of peptide and non-peptide ligands in the cloned rat κ opioid receptor, J. Biol. Chem., 269 (1994) 30195-30199.