Effects of growth hormone (GH) replacement on bone metabolism and mineral density in adult onset of GH deficiency: Results of a double-blind placebo-controlled study with open follow-up

European Journal of Endocrinology

Volumn 136, Issue 3, 1997, Pages 282-289

  Finkenstedt, Gerd ^a   Gasser, Rudolf W ^a   Höfle, Günter ^a   Watfah, Christine ^a   Fridrich, Leo ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; RECOMBINANT GROWTH HORMONE;

ADULT; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0030995228     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1360282     Document Type: Article

References (26)

1. Wuster C, Slenczka E & Ziegler R. Increased prevalence of osteoporosis and arteriosclerosis in patients with conventionally substituted pituitary insufficiency - is there a need for additional growth hormone substitution. Klinische Wochenschrift 1991 69 769-773.
2. Rosén T, Hansson T, Granhed H, Szucs J & Bengtsson BA. Reduced bone mineral content in adult patients with growth hormone deficiency. Acta Endocrinologica 1993 129 201-206.
3. Holmes SJ, Economou G, Whitehouse RW, Adams JE & Shalet SM. Reduced bone mineral density in patients with adult onset growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism 1994 78 669-674.
4. Beshyah SA, Freemantle C, Thomas E, Rutherford O, Page B, Murphy M et al. Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Clinical Endocrinology 1995 42 179-189.
5. Diamond T, Nery L & Posen S. Spinal and peripheral bone densities in acromegaly: the effects of excess growth hormone and hypogonadism. Annals of Internal Medicine 1989 111 567-573.
6. Schlemmer A, Johansen JS, Pedersen SA, Jorgensen JOL, Hassager C & Christiansen C. The effect of growth hormone (GH) therapy on urinary pyridinoline cross-links in GH-deficient adults. Clinical Endocrinology 1991 35 471-476.
7. Sartorio A, Conti A, Monzani M, Morabito F & Faglia G. Growth hormone treatment in adults with GH deficiency - effects on new biochemical markers of bone and collagen turnover. Journal of Endocrinological Investigation 1993 16 893-898.
8. Binnerts A, Swart GR, Wilson JHP, Hoogerbrugge N, Pols HAP, Birkenhager JC et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clinical Endocrinology 1992 37 79-87.
9. Vandeweghe M, Taelman P & Kaufman JM. Short-term and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males. Clinical Endocrinology 1993 39 409-415.
10. Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A & Johnston DG. The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Clinical Endocrinology 1994 40 383-391.
11. Beshyah SA, Kyd P, Thomas E, Fairney A & Johnston DG. The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults. Clinical Endocrinology 1995 42 249-254.
12. Degerblad M, Bengtsson BA, Bramnert M, Johnell O, Manhem P, Rosén T et al. Reduced bone mineral density in adults with growth hormone (GH) deficiency: Increased bone turnover during 12 months of GH substitution therapy. European Journal of Endocrinology 1995 133 180-188.
13. Balducci R, Toscano V, Pasquino AM, Mangiantini A, Municchi G, Armenise P et al. Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy. European Journal of Endocrinology 1995 132 42-46.
14. Degerblad M, Elgindy N, Hall K, Sjoberg HE & Thorén M. Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinologica 1992 126 387-393.
15. O'Halloran DJ, Tsatsoulis A, Whitehouse RW, Holmes SJ, Adams JE & Shalet SM. Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. Journal of Clinical Endocrinology and Metabolism 1993 76 1344-1348.
16. Whitehead HM, Boreham C, McIlrath EM, Sheridan B, Kennedy L, Atkinson AB et al. Growth hormone treatment of adults with growth hormone deficiency - results of a 13-month placebo controlled cross-over study. Clinical Endocrinology 1992 36 45-52.
17. Thorén M, Soop M, Degerblad M & Saaf M. Preliminary study of the effects of growth hormone substitution therapy on bone mineral density and serum osteocalcin levels in adults with growth hormone deficiency. Acta Endocrinologica 1993 128 41-43.
18. Amato G, Carella C, Fazio S, Lamontagna G, Cittadini A, Sabatini D et al. Body composition, bone metabolism, and heart structure and function in growth hormone (GH) deficient adults before and after GH replacement therapy at low doses. Journal of Clinical Endocrinology and Metabolism 1993 77 1671-1676.
19. Holmes SJ, Whitehouse RW, Swindell R, Economou G, Adams JE & Shalet SM. Effect of growth hormone replacement on bone mass in adults with adult onset of growth hormone deficiency. Clinical Endocrinology 1995 42 627-633.
20. Nordin BEC & Bulusu L. A modified index of phosphate excretion. Postgraduate Medical Journal 1968 44 93-97.
21. Burstein S, Chen IW & Tsang RC. Effects of growth hormone replacement therapy on 1,25-dihydroxyvitamin D and calcium metabolism. Journal of Clinical Endocrinology and Metabolism 1983 56 1246-1251.
22. Brixen K, Nielsen HK, Bouillon R, Flyvbjerg A & Mosekilde L. Effects of short-term growth hormone treatment on PTH, calcitriol, thyroid hormones, insulin and glucagon. Acta Endocrinologica 1992 127 331-336.
23. Nass R, Huber RM, Klauss V, Muller OA, Schopohl J & Strasburger CJ. Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. Journal of Clinical Endocrinology and Metabolism 1995 80 552-557.
24. Overgaard K, Hansen MA, Jensen SB & Christiansen C. Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis - a dose-response study. British Medical Journal 1992 305 556-561.
25. Harris ST, Watts NB, Jackson RD, Genant HK, Wasnich RD, Ross P et al. Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis - three years of blinded therapy followed by one year of open therapy. American Journal of Medicine 1993 95 557-567.
26. Pak CYC, Sakhaee K, Adamshuet B, Piziak V, Peterson RD & Poindexter JR. Treatment of postmenopausal osteoporosis with slow-release sodium fluoride. Final report of a randomized controlled trial. Annals of Internal Medicine 1995 123 401-408.