Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children

Pediatric Infectious Disease Journal

Volumn 16, Issue 6, 1997, Pages 555-560

  Cohen, Robert ^a   Bingen, Edouard ^b   Varon, Emmanuelle ^c   De La Rocque, France ^e   Brahimi, Nahima ^b   Levy, Corinne ^e   Boucherat, Michel ^e   Langue, Jacques ^d   Geslin, Pierre ^a  

^a CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c HÔTEL DIEU   (France)

^d Assoc Francaise Pediat Ambulatoire   (France)

^e Service de Microbiologie ^*

Author keywords

Acute otitis media; Antibiotic therapy; Nasopharyngeal flora; Penicillin resistance; Streptococcus pneumoniae

Indexed keywords

PENICILLIN G;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL GROWTH; HUMAN; INFANT; MAJOR CLINICAL STUDY; MOUTH FLORA; OTITIS MEDIA; PRESCHOOL CHILD; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; AMOXICILLIN; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; CEFTIZOXIME; CHILD, PRESCHOOL; CLAVULANIC ACIDS; FEMALE; HUMANS; INFANT; MALE; NASOPHARYNX; OTITIS MEDIA; PENICILLIN RESISTANCE; PROSPECTIVE STUDIES; STREPTOCOCCUS PNEUMONIAE;

EID: 0030995054     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199706000-00004     Document Type: Article

References (33)

1. Faden H, Stniaevich J, Brodsky L, Bernstein J, Ogra PL. Change in nasopharyngeal flora during otitis media of childhood. Pediatr Infect Dis J 1990;9:623-6.
2. Leach A, Boswell J, Asche V, Nienhuys T, Mathews J. Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants. Pediatr Infect Dis J 1994;13:983-9.
3. Zenny M, Cheatham S, Thompson J, et al. Streptococcus pneumoniae colonization in the young child: association with otitis media and resistance to penicillin. J Pediatr 1995;127: 533-7.
4. Harabuschi Y, Faden H, Yamanaka N, Duffy L, Wolf J, Kryofik D. Nasopharyngeal colonization with non-typable Haemophilus influenzae and recurrent otitis media. J Infect Dis 1994;170:862-6.
5. Spinola S, Peaco J, Denny F, Smith D, Cannon JG. Epidemiology of colonization by non-typable Haemophilus influenzae in children: a longitudinal study. J Infect Dis 1986;154: 100-9.
6. Anianson G, Aim B, Anderson B, et al. Nasopharyngeal colonization during the first year of life. J Infect Dis 1992; 165(Suppl):38-41.
7. Loda FA, Collier AM, Glezen WP, Strangert K, Clyde WA, Denny FW. Occurrence of Diplococcus pneumoniae in the upper respiratory tract of children. J Pediatr 1975;87:1087-93.
8. Geslin P. Béta-lactamines et pneumocoques multi-résistants isolés en France. Med Hyg 1995;53:2111-8.
9. Gray B, Converse G, Dillon H. Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage and infection during the first 24 months of life. J Infect Dis 1980;142:923-33.
10. Cohen R, de La Rocque F, Boucherat M et al. Treatment failure in otitis media: an analysis. J. Chemother 1994; 6(Suppl):17-22.
11. Gehanno P, Lenoir G, Berche P. In vivo correlates for Streptococcus pneumoniae penicillin-resistance in acute otitis media. Antimicrob Agents Chemother 1995;39:271-2.
12. Cohen R, Levy C, de La Rocque F, et al. Nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae (Sp) increases the risk of antibiotic treatment failures in acute otitis media (AOM) [Abstract C6]. Presented at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 18 to 20, 1995.
13. Gehanno P, Lenoir G, Barry B, Bons J, Boucot I, Berche P. Evaluation of nasopharyngeal cultures for bacteriologic assessment of acute otitis media in children. Pediatr Infect Dis 1996;15:329-32.
14. de La Rocque F, Boucherat M, Levy C, Langue J, Bourillon A, Cohen R. Etude randomisée cefpodoxime-proxetil 5 jours versus amoxicilline acide clavulanique 8 jours dans le traitement de l'otite moyenne aiguë de l'enfant [Session C18, Abstract 337]. Presented at the 14th Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse, Paris, 1994.
15. Paradise J. On classifying otitis media as suppurative or non suppurative with a suggested clinical scheme. J Pediatr 1987;111:948-51.
16. National Committee of Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: fourth informational supplement (NCCLS Document M7-A3). Villanova, PA: National Committee of Clinical Laboratory Standards, 1994.
17. Bingen E, Bare MC, Brahimi N, Vilmer E, Beaufils F. Randomly amplified polymorphic DNA analysis provides rapid differentiation of methicillin-resistant coagulase negative Staphylococcus bacteremia isolates in pediatric hospital. J Clin Microbiol 1995;33:1657-9.
18. Hakenbeck R, Briese T, Chalkley L, et al. Variability of penicillin binding proteins from penicillin-sensitive Streptococcus pneumoniae. J Infect Dis 1991;164:307-12.
19. Sifaoui F, Kitzis MD, Gutmann L. In vitro selection of one-step mutants of Streptococcus pneumoniae resistant to different oral beta-lactam antibiotics is associated with alterations of PBP2x. Antimicrob Agents Chemother 1996;40: 152-6.
20. Ford KL, Mason EO Jr, Kaplan SL, Lamberth LB, Tillman J. Factors associated with middle ear isolates of Streptococcus pneumoniae resistant to penicillin in a children's hospital. J Pediatr 1991;119:941-4.
21. Reichler M, Allphin A, Breiman R, et al. The spread of multiply resistant Streptococcus pneumoniae at a day-care center in Ohio. J Infect Dis 1992;166:1346-54.
22. Lenoir G, Gehanno P, Boucot I, Berche P. Penicillin resistance and nasopharyngeal carriage of Streptococcus pneumoniae in France in children with acute otitis media [Abstract J62]. Presented at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, FL, October 4 to 7, 1994.
23. Brook I, Gober AE. Prophylaxis with amoxicillin or sulfisoxazole for otitis media: effect on the recovery of penicillin-resistant bacteria from children. Clin Infect Dis 1996;22: 143-5.
24. Carsenti-Etesse H, Durant J, De Salvador F, et al. In vitro development of resistance to beta-lactam antibiotics in Streptococcus pneumoniae. J Antimicrob Chemother 1995;36:417-23.
25. Coffey TJ, Dowson CG, Daniels M, et al. Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. Mol Microbiol 1991;5:2255-60.
26. Sibold C, Wang J, Henrichsen J, Hakenbeck R. Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect Immun 1992;60:4119-26.
27. Garcia de Lomas J, Gimeno C, Bermejo M, et al. High prevalence of oropharynx colonization by several Streptococcus pneumoniae strains displaying divergent susceptibility profiles among Spanish carriers [Abstract E13]. Presented at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 18 to 20, 1995.
28. Negri M, Morosoni M, Loza E, Baquero F. In vitro selective antibiotic concentrations of beta-lactams for penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother 1994;38:122-5.
29. Boken D, Chartrand S, Goering R, Kruger R, Harrison C. Colonization with penicillin-resistant Streptococcus pneumoniae in a child-care center. Pediatr Infect Dis J 1995;14: 879-84.
30. Johnson WG, Blackstock A, Pierce AK, Sanford J. The role of bacterial antagonism in pneumococcal colonization of the human pharynx. J Lab Clin Med 1970;75:946-52.
31. Sanders C, Sanders E, Harrowe D. Bacterial interference: effects of oral antibiotics on the normal flora and its ability to interfere with Group A streptococci. Infect Immun 1976;13:808-12.
32. Dowson CG, Coffey TJ, Kell C, Whiley R. Evolution of penicillin resistance in Streptococcus pneumonias: the role of Streptococcus mitis in the formation of the low affinity PBP 2 B in S. pneumoniae. Mol Microbiol 1993;9:635-43.
33. Dabernat H, Fremaux A, Geslin P, et al. Study of nasopharyngeal carriage and effects of two antibiotics on potential pathogens in children with acute otitis media [Abstract C6]. Presented at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 18 to 20, 1995.