Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4

Life Sciences

Volumn 60, Issue 15, 1997, Pages 1263-1269

  Misicka, Aleksandra ^a,c   Lipkowski, Andrzej W ^a,d   Horvath, Robert ^b   Davis, Peg ^b   Porreca, Frank ^b   Yamamura, Henry I ^b   Hruby, Victor J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WARSAW   (Poland)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

biphalin; opioid peptides

Indexed keywords

4 FLUOROPHENYLALANINE; AMINO ACID DERIVATIVE; BIPHALIN; DELTA OPIATE RECEPTOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; FENCLONINE; GLYCINE; MU OPIATE RECEPTOR; OPIATE PEPTIDE; OPIATE RECEPTOR; PHENYLALANINE; RADIOLIGAND;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; MOUSE; NONHUMAN; RADIORECEPTOR ASSAY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ANALGESICS; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; GUINEA PIGS; ILEUM; MALE; MICE; MICE, INBRED ICR; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030994795     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00069-6     Document Type: Article

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