Molecular bases of three characteristic phenotypes of pneumococcus: Optochin-sensitivity, coumarin-sensitivity, and quinolone-resistance

Microbial Drug Resistance

Volumn 3, Issue 2, 1997, Pages 177-196

  De La Campa, Adela G ^a   García, Ernesto ^b   Fenoll, Asunción ^c   Muñoz, Rosario ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AGAR; AMINO ACID; ANTIMALARIAL AGENT; CINCHONA ALKALOID; CIPROFLOXACIN; COUMARIN DERIVATIVE; DIHYDROLIPOAMIDE DEHYDROGENASE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); EPIQUINIDINE; EPIQUININE; ETHYLHYDROCUPREINE; LEUCINE; NOVOBIOCIN; OLIGOMYCIN; PROTEIN; PROTEOLIPID; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; QUINIDINE; QUININE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; SERINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE; VENTURICIDIN;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTALLOGRAPHY; DRUG BINDING; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; GENE; GENE MAPPING; GROWTH INHIBITION; MALARIA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OPEN READING FRAME; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS ORALIS; STREPTOCOCCUS PNEUMONIAE;

CINCHONA PUBESCENS; ESCHERICHIA COLI; PNEUMOCOCCUS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS PNEUMONIAE;

EID: 0030994516     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.1997.3.177     Document Type: Article

References (19)

1. Adachi, T., M. Mizuuchi, E.A. Robinson, E. Appella, M.H. O'Dea, M. Gellert, and K. Mizuuchi. 1987. DNA sequence of E. coli gyrB gene: Application of a new sequencing strategy. Nucleic Acids Res. 15:771-784.
2. Appelbaum, P.C. 1992. Antimicrobial resistance in Streptococcus pneumoniae: An overview. Clin. Infect. Dis. 15:77-83.
3. Baquero, F. 1995. Pneumococcal resistance to β-lactam antibiotics: A global overview. Microb. Drug Resist. 1:115-120.
4. Belland, R., S. Morrison, C. Ison, and W. Huang. 1994. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14:371-380.
5. Blum, J J., A. Yayon, S. Friedman, and H. Ginsburg. 1984. Effects of mitochondrial protein synthesis inhibitors on the incorporation of isoleucine into Plasmodium falciparum. J. Protozool. 31:475-479.
6. Bowler, L.C., Q.-Y. Zhang, J.-Y. Riou, and B.G. Spratt. 1994. Interspecies recombination between the penA genes of Neisseria meningitidis and comensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: Natural events and laboratory simulation. J. Bacteriol. 176:333-337.
7. Brusilow, W.S., M.A. Scarpetta, C.A. Hawthorne, and W.P. Clark. 1989. Organization and sequence of the genes coding for the proton-translocating ATPase of Bacillus megaterium. J. Biol. Chem. 264:1528-1533.
8. Choi, I., and J.L. Mego. 1988. Purification of Plasmodium falciparum digestive vacuoles and partial characterization of the vacuolar membrane ATPase. Mol. Biochem. Parasitol. 31:71-78.
9. Coffey, T.J., C.G. Dowson, M. Daniells, and B.G. Spratt 1993. Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis. FEMS Microbiol. Lett. 110:335-340.
10. Contreras, A., and A. Maxwell. 1992. gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase. Mol. Microbiol. 6:1617-1624.
11. Cozens, A.L., and J.E. Walker. 1987. The organization and sequence of the genes of the ATP synthase in the cyanobacterium Synechococcus 6301: Support for an endosymbiotic origin of chloroplasts. J. Mol. Biol. 194:359-383.
12. Cullen, M., A. Wyke, R. Kuroda, and L. Fisher. 1989. Cloning and characterization of a DNA gyrase gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob. Agents. Chemother. 33:886-894.
13. del Castillo, I., J.L. Vizán, M.C. Rodriguez-Sáinz, and F. Moreno. 1991. An unusual mechanism for resistance to the antibiotic coumermycin A1. Proc. Natl. Acad. Sci. USA 88:8860-8864.
14. Dowson, C.G., A. Hutchison, N. Woodford, A.P. Johnson, R.C. George, and B.G. Spratt. 1990. Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA 87:5858-5862.
15. +-ATPases. Mol. Microbiol. 12:587-598.
16. +-ATPases. Dev. Biol. Stand. 85:287-291.
17. Ferrero, L., B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure or Staphylococcus aureus DNA topoisomerase IV: A primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
18. +-ATPase): Results by combined biochemical and molecular biological approaches. Annu. Rev. Biochem. 58:111-136.
19. Gasc, A.-M., L. Kauc, P. Barraillé, M. Sicard, and S. Goodgal. 1991. Gene localization, size, and physical map of the chromosome of Streptococcus pneumoniae. J. Bacteriol. 173:7361-7367.