Theophylline for infants with abnormal pneumographic results. A randomized double blind, placebo-controlled trial

Klinische Padiatrie

Volumn 209, Issue 2, 1997, Pages 66-70

  Paky, Franz ^a,b   Donath, Peter ^a   Huebmer, Edith ^a   Stögmann, Walter ^a  

^a Intensive Care Unit   (Austria)

^b Abt F Kinder und Jugendheilkunde   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; THEOPHYLLINE;

APNEA; ARTICLE; BREATHING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SCREENING; HUMAN; INFANT; MAJOR CLINICAL STUDY; NEWBORN; PNEUMOGRAPHY; RANDOMIZED CONTROLLED TRIAL;

EID: 0030993902     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043930     Document Type: Article

References (48)

1. American Academy of Pediatrics, Committee on Drug: Precautions concerning the use of theophylline. Pediatrics 89 (1992) 781-783
2. Barrington, K. J., N. N. Finer, G. Torok-Both, F. Jamali, R. T. Coutts: Dose-response relationship of doxapram in the therapy for refractory idiopathic apnea of prematurity. Pediatrics 80 (1987) 22-27
3. Barrington, K. J., N. N. Finer: Periodic breathing and apnea in preterm infants. Pediatr. Res. 27 (1990) 118-121
4. Barrington, K. J., N. N. Finer, K. L. Peters, J. Barton: Physiologic effects of doxapram in idiopathic apnea of prematurity J. Pediatr. 108 (1986) 124-129
5. Brooks, J. G.: Apnea of infancy and sudden infant death syndrome. Am. J. Dis. Child. 136 (1982) 1012-1023
6. Chasnoff, I. J., C. E. Hunt, R. Kletter, D. Kaplan: Prenatal cocaine exposure is associated with respiratory pattern abnormalities. Am. J. Dis. Child. 143 (1989) 583-587
7. Daily, W. J. R., M. Klaus, H. P. B. Meyer: Apnea in premature infants: monitoring, incidence, heart rate changes, and an effect of environmental temperature. Pediatrics 45 (1969) 510-518
8. Eyal, F. u. Mitarb.: Aminophylline versus doxapram in idiopathic apnea of prematurity: a double-blind controlled study. Pediatrics 75 (1985) 709-713
9. Finer, N. N., K. L. Peters, L. M. Duffley, J. H. Coward: An evaluation of theophylline for idiopathic apnea of infancy: Dev. Pharmacol. Ther. 7 (1984) 73-81
10. Finer, N. N., K. J. Barrington, B. Hayes: Prolonged periodic breathing: significance in sleep studies. Pediatrics 89 (1992) 450-453
11. Glotzbach, S. F., R. B. Baldwin, N. E. Lederer, P. A. Tansey, R. L. Ariagno: Periodic breathing in preterm infants: incidence and characteristics. Pediatrics 84 (1989) 785-792
12. Glotzbach, S. F., P. A. Tansey, R. B. Baldwin, R. L. Ariagno: Periodic breathing in preterm infants: influence of bronchopulmonary dysplasia and theophylline. Pediatr. Pulmonol. 7 (1989) 78-81
13. Hächl, G., F. Schabel: Erfahrungen mit der Aminophyllin-Prophylaxe (Euphyllin) bei Apnoen und periodischer Atmung bei Säuglingen. Pädiatr. Pädol. 23 (1988) 115-119
14. Hageman, J. R., D. Holmes, S. Suchy, C. E. Hunt: Respiratory pattern at hospital discharge in asymptomatic preterm infants. Pediatr. Pulmonol. 4 (1988) 78-83
15. Hodgman, J. E., F. Gonzales, T. Hoppenbrouwers, L. A. Cabal: Apnea, transient episodes of bradycardia and periodic breathing in preterm infants. Am. J. Dis. Child. 144 (1990) 54-57
16. Hunt, C. E., R. T. Brouillette, D. Hanson: Theophylline improves pneumogram abnormalities in infants at risk for sudden infant death syndrome. J. Pediatr. 103 (1983) 969-974
17. Kelly, D. H., D. C. Shannon: Periodic breathing in infants with near-miss sudden infant death syndrome. Pediatrics 63 (1979) 355-360
18. Kelly, D. H., D. C. Shannon: Treatment of apnea and excessive periodic breathing in the full-term infant. Pediatrics 68 (1981) 183-186
19. Kelly, D. H., D. C. Shannon: Episodic complete airway obstruction in infants. Pediatrics 67 (1981) 823-827
20. Kelly, D. H., J. Twanmoh, D. C. Shannon: Incidence of apnea in siblings of sudden infant death syndrome victims studied at home. Pediatrics 70 (1982) 128-131
21. Kelly, D. H., H. Golub, D. Carley, D. C. Shannon: Pneumograms in infants who subsequently died of sudden infant death syndrome. J. Pediatr. 109 (1986) 249-254
22. Kurz, H., F. Paky, W. Stögmann: Obstruktive Apnoen bei Frühgeborenen und Säuglingen. Klin. Pädiatr. 206 (1994) 425-429
23. Kuzemko, J. A., J. Paala: Apnoeic attacks in the newborn treated with aminophylline. Arch. Dis. Child. 48 (1973) 404-406
24. Lagercrantz, H.: What does the preterm breathe for? Controversies on apnea of prematurity Acta Paediatr. 81 (1992) 733-736
25. Manning, D. J., J. K. Strothers: Sleep state, hypoxia and periodic breathing in the neonate. Acta Paediatr. Scand. 80 (1991) 763-769
26. McDonnell, M., N. K. Ives, P. L. Hope: Intravenous aminophyllin and cerebral blood flow in preterm infants. Arch. Dis. Child. 67 (1992) 416-418
27. Muttitt, S. C., A. J. Tierney, N. N. Finer: The dose response of theophylline in the treatment of apnea of prematurity. J. Pediatr. 112 (1988) 115-121
28. Myers, T. F., R. L. Mislap, A. N. Krauss, P. A. M. Auld, M. M. Reidenberg: Low dose theophyllin therapy in idiopathic apnea of prematurity. J. Pediatr. 96 (1980) 99-103
29. O'Brien, M. J.: Respiratory EMG findings in relation to periodic breathing in infants. Early Hum. Dev 11 (1985) 43-60
30. Peliowski, A., N. N. Finer: A blinded, randomized, placebo-controlled trial to compare theophylline and doxapram for the treatment of apnea of prematurity J. Pediatr. 116 (1990) 648-653
31. Prechtl, H. F. R., L. A. van Eykern, M. J. O'Brien: Respiratory muscle EMG in newborns: a non-intrusive method. Early Hum. Dev. 1/3 (1977) 265-283
32. Reiterer, F., R. Schenken, R. Kurz, R. Haidmayer: Effekt einer Aminophyllintherapie beim reifgeborenen Säugling mit Schlafapnoesyndrom. Monatsschr. Kinderhlkd. 136 (1988) 368-371
33. Richards, J. M., J. R. Alexander, E. A. Shinebourne, M. de Swiet, A. J. Wilson, D. P Southall: Sequential 22-hour profiles of breathing patterns and heart rate in 110 full-term infants during their first 6 months of life. Pediatrics 74 (1984) 763-777
34. Roberts, J. L., O. P Mathew, B. T. Thach: The efficiacy of theophylline in premature infants with mixed and obstructive apnea and apnea associated with pulmonary and neurologic disease. J. Pediatr. 100 (1982) 968-970
35. Roberts, J. L., O. P. Mathew, B. T. Thach: Observations made on severe apneic spells in two infants at risk for sudden death. Early Hum. Dev. 10 (1985) 261-271
36. Ruggins, N. R.: Pathophysiology of apnoea in preterm infants. Arch. Dis. Child. 66 (1991) 70-73
37. Sagi, E., F. Eyal, G. Alpan, D. Patz, I. Arad: Idiopathic apnoea of prematurity treated with doxapram and aminophylline. Arch. Dis. Child. 59 (1984) 281-283
38. Scanlon, J. E. M., K. C. Chin, M. E. I. Morgan, G. M. Durbin, K. A. Hale, S. S. Brown: Caffeine or theophylline for neonatal apnoea? Arch. Dis. Child. 67 (1992) 425-428
39. Shannon, D. C., F. Gotay, I. M. Stein, M. C. Rogers, I. D. Todres, F. M. B. Moylan: Prevention of apnea and bradycardia in low-birth-weight infants. Pediatrics 55 (1975) 589-594
40. Shannon, D. C., F. H. Jr. Lovejoy: Effect of acute versus chronic intoxication on clinical features of theophylline poisoning in children. J. Pediatr. 121 (1992) 125-130
41. Skopnik, H., U. Bergt, G. Heimann: Neonatal theophyllin intoxication: pharmacokinetics and clinical evaluation. Eur. J. Pediatr. 151 (1992) 221-224
42. Southall, D. P. u. Mitarb.: Prolonged apnea and cardiac arrythmias in infants discharged from neonatal intensive care units: failure to predict an increased risk for sudden infant death syndrome. Pediatrics 70 (1982) 844-851
43. Southall, D. P.: Home monitoring and its role in the sudden infant death syndrome. Pediatrics 72 (1983) 133-138
44. Steinschneider A.: Prolonged sleep apnea and respiratory instability: a discriminative study. Pediatrics 59 (1977) 962-970
45. Uauy, R., D. Shapiro, B. Smith, J. B. Warshaw: Effect of theophylline on severe primary apnea of prematurity: A preliminary report. Pediatrics 55 (1975) 595-598
46. Vandenplas, Y., D. De Wolf, L. Sacre: Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome. Pediatrics 77 (1986) 807-810
47. Waggener, T. B., D. P. Southall, L. A. Scott: Analysis of breathing patterns in a prospective population of term infants does not predict susceptibility to sudden infant death syndrome. Pediatr. Res. 27 (1990) 113-117
48. Ward, S. L. D. u. Mitarb.: Sudden infant death syndrome in infants evaluated by apnea programs in California. Pediatrics 77 (1986) 451-455