5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors

Human Reproduction

Volumn 12, Issue 2, 1997, Pages 361-367

  Karlsson, Caroline ^a   Bodelsson, Gunilla ^a   Bodelsson, Mikael ^a   Stjernquist, Martin ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT receptors; Smooth muscle; Uterine artery (human)

Indexed keywords

ALPHA METHYLSEROTONIN; BEMESETRON; KETANSERIN; METITEPINE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SUMATRIPTAN;

ADULT; AGED; ARTERY CONSTRICTION; ARTERY MUSCLE; ARTICLE; DRUG POTENCY; FEMALE; HUMAN; HUMAN TISSUE; NORMAL HUMAN; UTERINE ARTERY;

EID: 0030993824     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.2.361     Document Type: Article

References (36)

1. Arunlakshana, O. and Schild, H.O. (1959) Some quantitative uses of drug antagonists. Br. J. Pharmacol., 58, 48-58.
2. Bodelsson, G. and Stjernquist, M. (1992) Smooth muscle dilatation in human uterine artery induced by substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide and atrial natriuretic peptide: relation to endothelium-derived relaxing substances. Hum. Reprod., 7, 1185-1188.
3. Bodelsson, G., Owman, C., Poulsen, H. et al., (1991) Relaxation of the human uterine artery by atrial natriuretic peptide (ANP) is independent of the endothelium. Am. J. Obstet. Gynecol. 165, 483-484.
4. Bodelsson, G., Sjöberg, N. and Stjernquist, M. (1992a) Contractile effect of endothelin in the human uterine artery and autoradiographic localization of its binding sites. Am. J. Obstet. Gynecol., 167, 745-750.
5. Bodelsson, M., Törnebrandt, K., Bertilsson, I.-L. and Arneklo-Nobin, B. (1992b) Heterogeneity of contractile 5-HT receptors in human hand veins. Eur. J. Pharmacol., 219, 455-460.
6. Bradley, P.B., Engel, G., Feniuk, W. et al. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology, 25, 563-576.
7. Chester, A., Bodelsson, M., Arneklo-Nobin, B. et al. (1990a) Characterisation of 5-HT receptors in the human saphenous vein, implications for patency of bypass grafts. J. Appl. Cardiol., 5, 51-59.
8. Chester, A., Martin, G., Bodelsson, M, et al. (1990b) 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc. Res., 24, 932
9. Ekesbo, R., Alm, P., Ekstrom, P. et al. (1991) Innervation of the human uterine artery and contractile responses to neuropeptides. Gynecol. Obstet. Invest., 31, 30-36.
10. Fontes Ribeiro, C.A. and Macedo, T.A. (1986) Pharmacological characterization of the postsynaptic alpha-adrenoceptors in human uterine artery. J. Pharm. Pharmacol., 38, 600-605.
11. Fontes Ribeiro, C.A., Macedo, T.R.A. and Porfiro, M.H. (1991) Pharmacological characterization of the postsynaptic serotonergic receptor in the human uterine artery. Pharmacology, 43, 264-272.
12. Gerhson, M.D. and Tamir, H. (1985) Peripheral sources of serotonin and serotonin-binding proteins. In Vanhoutte, P.M. (ed.), Serotonin and the Cardiovascular System. Raven Press, New York, pp. 15-26.
13. Gillis, C.N. (1985) Peripheral metabolism of serotonin. In Vanhoutte, P.M. (ed.), Serotonin and the Cardiovascular System. Raven Press, New York, pp. 27-36.
14. Hoyer, D., Clarke, D., Fozard, J. et al. (1994) International union of pharmacological classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157-203.
15. Högestätt, E.D., Andersson, K.-E. and Edvinsson, L. (1983) Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol. Scand., 117, 49-61.
16. 1-like receptor in dog isolated saphenous vein. Br. J. Pharmacol., 94, 1123-1132.
17. 2 binding profiles of the serotonergic agents α-methylserotonin and 2-methylserotonin. J. Med. Chem., 33, 755-758.
18. 3 receptors. Med. Res. Rev., 10, 441-475.
19. Ludbroock, J. (1994) Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res., 28, 303-311.
20. 2 receptors independent of cyclo-oxygenase mediate contraction of the human umbilical artery. Br. J. Pharmacol., 97, 921-933.
21. Owman, C. and Stjernquist, M. (1988) Origin, distribution, and functional aspects of aminergic and peptidergic nerves in the male and female reproductive tracts. In Björklund, A., Hökfelt, T. and Owman, C. (eds), Handbook of Chemical Neuroanatomy. Elsevier Science Publishers, Amsterdam, pp. 445-544.
22. Poulsen, H., Stjernquist, M. and Sjöberg, N.-O. (1993) Is ANP responsible for the hemoconcentration in preeclampsia? Med. Hypoth., 41, 235-238.
23. Poulsen, H., Sjöberg, N.-O., Stjernquist, M. and Zia, E. (1994) Atrial natriuretic peptide antagonizes the contractile effect of angiotensin II in the human uterine artery. Hum. Reprod., 9, 1939-1943.
24. Purdy, A., Murray, D. and Stupecky, G. (1987) Receptors for 5-hydroxytryptamine in rabbit blood vessels: activation of alpha adrenoceptors in rabbit thoracic aorta. J. Pharmacol. Exp. Ther., 240, 535-541.
25. Richardson, B., Engel, G., Donatsch, P. and Stadler, P. (1985) Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature, 316, 126-131.
26. Stener-Victorin, E., Waldenström, U., Andersson, S. and Wikland, M. (1996) Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum. Reprod., 11, 1314-1317.
27. Stjernquist, M. and Owman, C. (1985) Cholinergic and adrenergic neuronal control of smooth muscle function in the non-pregnant rat uterine cervix. Acta Physiol. Scand., 124, 429-436.
28. Stjernquist, M. and Owman, C. (1990) Adrenoceptors mediating contraction in the human uterine artery. Hum. Reprod., 5, 19-24.
29. Stjernquist, M., Ekblad, E., Nordstedt, E. and Radzuweit, C. (1991) Neuropeptide Y (NPY) co-exists with tyrosine hydroxylase and potentiates the adrenergic contractile response of vascular smooth muscle in the human uterine artery. Hum. Reprod., 6, 1034-1038.
30. Stoltz, J.F. (1985) Uptake and storage of serotonin by platelets. In Vanhoutte, P.M. (ed.), Serotonin and the Cardiovascular System. Raven Press, New York, pp. 38-42.
31. 3 receptor agonist? Br. J. Pharmacol, 105, 34P
32. Tekay, A., Martikainen, H. and Jouppila, P. (1996) Comparison of uterine blood flow characteristics between spontaneous and stimulated cycles before embryo transfer. Hum. Reprod., 11, 364-368.
33. Törnebrandt, K., Nobin, A. and Owman, C. (1987) Serotonergic smooth muscle receptors in human mesenteric arteries and veins. In Nobin, A., Owman, C. and Arneklo-Nobin, B. (eds), Neuronal Messengers in Vascular Function. Elsevier Science Publishers, Amsterdam, pp. 31-44.
34. Victorzon, M., Tapparelli, C. and Muller-Schweinitzer, E. (1986) Comparison of the actions of serotonergic agents on human saphenous veins and platelets. Eur. J. Pharmacol., 124, 107-111.
35. 2 receptors. Pharmacol. Toxicol., 78, 50-54.
36. Weiner, C.P. (1987) The role of serotonin in the genesis of hypertension in preeclampsia. Am. J. Obstet. Gynecol., 4, 885-888.