Hypertonic saline activates protein tyrosine kinases and mitogen- activated protein kinase p38 in T-cells

Journal of Trauma - Injury, Infection and Critical Care

Volumn 42, Issue 3, 1997, Pages 437-445

  Junger, Wolfgang G ^a,c   Hoyt, David B ^a   Hamreus, Megan ^a   Liu, Forrest C ^a   Herdon Remelius, Crystal ^a   Junger, Werner ^a   Altman, Amnon ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c UCSD MEDICAL CENTER   (United States)

Author keywords

Hypertonic saline resuscitation; Mitogen activated protein kinase p38 (MAPK p38); Osmotic stress; T cell signaling

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SODIUM CHLORIDE;

CELL PROLIFERATION; CONFERENCE PAPER; HEMODYNAMICS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MONONUCLEAR CELL; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESUSCITATION; SEPSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0030992943     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199703000-00011     Document Type: Conference Paper

References (43)

1. Baker CC, Oppenheimer L, Lewis FR, et al: The epidemiology of trauma death. Am J Surg 140:144, 1980
2. Alexander JW, Moncrief JA: Alterations of the immune response following severe thermal injury. Arch Surg 93:75, 1966
3. Hakim AA: An immunosuppressive factor from serum of thermally traumatized patients. J Trauma 17:908, 1972
4. Chaudry IH, Ayala A: Immunological Aspects of Hemorrhage. Austin-Georgetown, RG Landes Company, 1992, pp 1-132
5. Junger WG, Hoyt DB, Cardoza TA, et al: Immunosuppressive activity in septic trauma patient serum is sustained and correlates with severity of multi-organ failure. Circ Shock 40(suppl 1):9, 1993
6. Hoyt DB, Junger WG, Loomis WH, et al: Effects of trauma on immune cell function: Impairment of intracellular calcium signalling. Shock 2:23, 1994
7. Ozkan AN, Hoyt DB, Tompkins S, et al: Immunosuppressive effects of a trauma-induced suppressor active peptide. J Trauma 28:589, 1988
8. Ozkan AN, Tompkins S, Gregory S, et al: Immunologic mechanisms of a trauma associated glycopeptide. J Leukocyte Biol 44:300, 1988
9. Hoyt DB, Ozkan AN, Easter D, et al: Isolation of an immunosuppressive trauma peptide and its relationship to fibronectin. J Trauma 28:907, 1988
10. Ozkan AN, Hoyt DB, Ninnemann JL: Generation and activity of suppressor peptides following traumatic injury. J Burn Care Rehabil 8:527, 1987
11. 2)-dependent suppression of interleukin a (IL-2) production in patients with major trauma. J Trauma 27:837, 1987
12. Miller-Graziano CL, Fink M, Wu J, et al: Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg 123:293, 1988
13. Martinez OM, Gibbons RS, Garovoy MR, et al: IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T-cells. J Immunol 144:2211, 1990
14. Taga K, Tosato G: IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148:1143, 1992
15. Wahl SM, Hunt DA, Wong HL, et al: Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J Immunol 140:3026, 1988
16. Ayala A, Meldrum DR, Perrin MM, et al: The release of transforming growth factor-β following haemorrhage: Its role as a mediator of host immunosuppression. Immunology 79:479, 1993
17. Ayala A, Deol ZK, Lehman DL, et al: Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 production. J Surg Res 56:579, 1994
18. Miller-Graziano CL, Szabo G, Griffey K, et al: Role of elevated monocyte transforming growth factor β (TGFβ) production in posttrauma immunosuppression. J Clin Immunol 11:95, 1991
19. Junger WG, Hoyt DB, Redl H, et al: Tumor necrosis factor antibody treatment of septic baboons reduces the production of sustained T-cell suppressive factors. Shock 3:173, 1995
20. Rowe GG, McKenna DH, Corliss RJ, et al: Hemodynamic effects of hypertonic sodium chloride. J Appl Physiol 32:182, 1972
21. Velasco IT, Pontieri V, Roche e Silva M, et al: Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol 239:H664, 1980
22. Traverso LW, Bellamy RF, Hollenbach SJ, et al: Hypertonic sodium chloride solutions: Effect on hemodynamics and survival after hemorrhage in swine. J Trauma 27:32, 1987
23. Brown JM, Grosso MA, Moore EE: Hypertonic saline and dextran: Impact on cardiac function in the isolated rat heart. J Trauma 30:646, 1990
24. Mattox KL, Maningas PA, Moore EE, et al: Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. multicenter trial. Ann Surg 213:482, 1991
25. Griswold JA, Anglin BL, Love RTJ, et al: Hypertonic saline resuscitation: Efficacy in a community-based burn unit. South Med J 84:692, 1991
26. Reed LL, Manglano R, Martin M, et al: The effect of hypertonic saline resuscitation on bacterial translocation after hemorrhagic shock in rats. Surgery 110:685, 1991
27. Junger WG, Liu FC, Loomis WH, et al: Hypertonic saline enhances cellular immune function. Circ Shock 42:190, 1994
28. 2)-induced T-cell suppression. Shock 4:45, 1995
29. 2 and interleukin-4 production. J Surg Res 64:203, 1996
30. Coimbra R, Hoyt DB, Junger WG, et al: Hypertonic saline resuscitation decreases susceptibility to sepsis following hemorrhagic shock. J Trauma. In press
31. Kanof ME, Smith PD, Zola H: Preparation of human mononuclear cell populations and subpopulations. In Coligan JE, Kruisbeck AM, Margulies DH, et al (eds): Current Protocols in Immunology. New York, Greene Publishing & Wiley-Interscience, 1995, pp 7.1.1-7.1.7
32. syk by T-cell antigen receptor/CD3 stimulation. Proc Natl Acad Sci U S A 91:5301, 1994
33. syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol 14:5249, 1994
34. Mustelin T, Coggeshall KM, Isakov N, et al: T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247:1584, 1990
35. Howe LR, Weiss A: Multiple kinases mediate T-cell-receptor signaling. Trends Biochem Sci 20:59, 1995
36. Han J, Lee J-D, Bibbs L, et al: A MAP kinase target by endotoxin and hyperosmolality in mammalian cells. Science 265:808, 1994
37. Raingeaud J, Gupta S, Rogers JS, et al: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270:7420, 1995
38. Galcheva-Gargova Z, Derijard B, Wu I-H, et al: An osmosensing signal transduction pathway in mammalian cells. Science 265:806, 1994
39. Maeda T, Wurgler-Murphy SM, Saito H: A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242, 1994
40. Csonka LN, Hanson AD: Prokaryotic osmoregulation: Genetics and physiology. Annu Rev Microbiol 45:569, 1991
41. 2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways. J Exp Med 178:1813, 1993
42. Wang P, Wu P, Siegel MI, et al: Interleukin (IL)-10 inhibits nuclear factor κB (NFκB) activation in human monocytes. J Biol Chem 270:9558, 1995
43. Ahuja SS, Paliogianni F, Yamada H, et al: Effect of transforming growth factor-β on early and late activation events in human T cells. J Immunol 150:3109, 1993