Synthesis, DNA binding and cytotoxicity of 1-[[ω-(9-acridinyl)amino]alkyl]carbonyl-3-(chloromethyl)-6-hydroxyindolines, a new class of DNA-targeted alkylating agents

Anti-Cancer Drug Design

Volumn 12, Issue 4, 1997, Pages 277-293

  Fan, Jun Yao ^a   Tercel, Moana ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adenine N3 adduct; Cytotoxicity; DNA footprinting; Guanine N7 adduct; seco CI compound; Sequence specific DNA alkylation

Indexed keywords

ACRIDINE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; NEW DRUG;

ARTICLE; DNA ALKYLATION; DNA DENATURATION; DNA FOOTPRINTING; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; DNA ADDUCTS; DNA FOOTPRINTING; DNA, NEOPLASM; INTERCALATING AGENTS; LEUKEMIA P388; MOLECULAR SEQUENCE DATA; TUMOR CELLS, CULTURED;

EID: 0030992004     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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