Long-term beneficial effects of BW619C89 on neurological deficit, cognitive deficit and brain damage after middle cerebral artery occlusion in the rat

Neuroscience

Volumn 77, Issue 4, 1997, Pages 1123-1135

  Smith, S E ^a   Hodges, H ^a   Sowinski, P ^a   Man, C M ^a   Leach, M J ^b   Sinden, J D ^a   Gray, J A ^a   Meldrum, B S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

behaviour; BW619C89; middle cerebral artery occlusion; rat; sodium channel antagonism; stroke

Indexed keywords

NEUROPROTECTIVE AGENT; SIPATRIGINE; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; COGNITION; CONTROLLED STUDY; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BEHAVIOR, ANIMAL; BRAIN ISCHEMIA; CEREBRAL ARTERIES; CEREBRAL CORTEX; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; MOTOR ACTIVITY; NERVOUS SYSTEM DISEASES; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; PIPERAZINES; PYRIMIDINES; RATS; RATS, INBRED F344; SODIUM CHANNEL BLOCKERS; TIME FACTORS;

EID: 0030991787     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00530-1     Document Type: Article

References (27)

1. Abdulla F. A., Smith S. E., Calaminici M., Stephenson J. D., Sinden J. D., Meldrum B. S. and Gray J. A. (1994) Cholinoceptor sensitivity and behavioural deficits after middle cerebral artery occlusion in rats. In Pharmacology of Cerebral Ischaemia (eds Kriegelstein J. and Oberpichler-Schwenk H.), pp. 531-540. Medpharm, Stuttgart.
2. Abdulla F. A., Calaminici M., Stephenson J. D. and Sinden J. D. (1994) Unilateral AMPA lesions of the nucleus basalis magnocellularis induce a sensorimotor deficit which is differentially affected by arecoline and nicotine. Behav. Brain Res. 60, 161-169.
3. Bederson J. B., Pitts L. H., Tsuji M., Nishimura M. C., Davis R. L. and Bartkowski H. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17, 472-476.
4. Dereski M. O., Chopp M., Knight R. A., Rodolosi L. C. and Garcia J. H. (1993) The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat. Acta neuropath. 85, 327-333.
5. Du C., Csernansky C. A., Hsu C. Y. and Choi D. W. (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J. cerebr. Blood Flow Metab. 16, 195-201.
6. Duverger D. and MacKenzie E. T. (1988) The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration and age. J. cerebr. Blood Flow Metab. 8, 449-461.
7. Eichenbaum H., Otto T. and Cohen N. J. (1994) Two functional components of the hippocampal memory system. Behav. Brain Sci. 17, 449-518.
8. Graham J. L., Smith S. E., Chapman A. G. and Meldrum B. S. (1994) Effect of lamotrigine on microdialysate glutamate concentration in the striatum after focal cerebral ischaemia in the rat. Br. J. Pharmac. Proc. Suppl. 112, 278P.
9. Graham S. H., Chen J., Sharp F. R. and Simon R. P. (1993) Limiting ischemic injury by inhibition of excitatory amino acid release. J. cerebr. Blood Flow Metab. 13, 88-97.
10. Hagan J. J. and Morris R. G. M. (1988) The cholinergic hypothesis of memory: a review of animal experiments. In Handbook of Psychopharmacology: Psychopharmacology of the Aging Nervous System (eds Iversen L. L., Iversen S. D. and Snyder S. H.), pp. 237-323. Plenum, New York.
11. Hirakawa M., Tamura A., Nagashima H., Nakayama H. and Sano K. (1994) Disturbance of retention of memory after focal cerebral ischemia in rats. Stroke 25, 2471-2475.
12. Hodges H., Sinden J., Turner J. J., Netto C. A., Sowinski P. and Gray J. A. (1992) Nicotine as a tool to characterise the role of the forebrain cholinergic projection system in cognition. In The Biology of Nicotine (eds Lipiello P. M., Collins A. C., Gray J. A. and Robinson J. H.), pp. 157-180. Raven, New York.
13. Hodges H., Sowinski P., Fleming P., Kershaw T. R., Sinden J. D., Meldrum B. S. and Gray J. A. (1966) Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischaemia in rats. Neuroscience 72, 959-988.
14. Jarvik M. E. and Kopp R. (1967) An improved one trial passive avoidance learning situation. Psychol. Rep. 21, 221-224.
15. Kataoka K., Hayakawa T., Ryotaro K. and Yuguchi K. (1991) Cholinergic deafferentation after focal cerebral infarcts in rats. Stroke 22, 1291-1296.
16. Leach M. J., Swan J. H., Eisenthal D., Dopson M. and Nobbs M. (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 4, 1339-1342.
17. Lin T. N., Yong Y. H., Grace W., Khan M. and Chung Y. H. (1993) Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24, 117-121.
18. Markgraf C. G., Green E. J., Hurwitz B. E., Morikawa E., Dietrich W. D., McCabe P. M., Ginsberg M. D. and Schneiderman N. (1992) Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res. 575, 238-246.
19. Meldrum B. S., Moncada C., Lekieffre D., Arvin B. and Smith S. (1992) Strategies for cerebroprotection: post-synaptic glutamate antagonism versus inhibition of ischaemia-induced glutamate release. In Pharmacology of Cerebral Ischemia (eds Krieglstein J. and Oberpichler-Schwenk H.), pp. 115-119. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
20. Meldrum B. S. (1995) Cytoprotective therapies in stroke. Curr. Opin. Neurol. 8, 15-23.
21. Morris R. G. M., Anderson E., Lynch G. S. and Baudry M. (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776.
22. Nishino H., Koide K., Aihara N., Kumazaki M., Sakurai T. and Nagai H. (1993) Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance. Brain Res. Bull. 32, 517-520.
23. Nunn J. A. and Hodges H. (1994) Cognitive deficits induced by global cerebral ischaemia: relationship to brain damage and reversal by transplants. Behav. Brain Res. 65, 1-31.
24. Okada M., Tamura A., Urae A., Nakagomi T., Kirino T., Mine K. and Fujiwara M. (1995) Long-term spatial cognitive impairment following middle cerebral artery occlusion in rats. A behavioral study. J. cerebr. Blood Flow Metab. 15, 505-512.
25. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic, Sydney.
26. Persson L., Hardemark H.-G., Bolander H. G., Hillered L. and Olsson Y. (1989) Neurological and neuropathological outcome after middle cerebral artery occlusion in rats. Stroke 20, 641-645.
27. Scorsa A., Smith S. E., Dawe G., Stephenson J. D., Cheetham M., Pilcher H., Schmidt Kastner R., Weigel H. and Meldrum B. S. (1995) Hippocampal effects after middle cerebral artery occlusion in rats. J. cerebr. Blood Flow Metab. 15 Suppl. 1, S310.