Hepatotoxicity of ethanol: Protective effect of calcium channel blockers in isolated hepatocytes

Liver

Volumn 17, Issue 2, 1997, Pages 76-82

  Cobreros, A ^a   Sainz, L ^a   Lasheras, B ^a   Cenarruzabeitia, E ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Calcium; Calcium channel blockers; Cytoprotection; Ethanol; Hepatoprotection

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER PROTECTIVE AGENT; NIFEDIPINE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT;

EID: 0030991464     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1997.tb00784.x     Document Type: Article

References (37)

1. NICOTERA P, BELLOMO G, ORRENIUS S. Calcium mediated mechanisms in chemically induced cell death. Annu Rev Pharmacol Toxicol 1992: 32: 449-470.
2. THOMAS C E, REED D J. Current status of calcium in hepatocellular injury. Hepatology 1989: 10: 375-384.
3. 2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 1987: 325: 78-81.
4. 2+ is mediated by the activation of a non-lysosomal proteolytic system. FEBS Lett 1986: 209: 139-144
5. LANDON E J, NAUKAM R J, SASTRY B V R. Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents. Biochem Pharmacol 1985: 35: 697-705.
6. REES K R, SPECTOR W G. Reversible nature of liver cell damage due to carbon tetrachloride as demonstrated by the use of Phenergan. Nature 1961: 190: 821-822.
7. 2+. Essays Biochem 1990: 25: 1-37.
8. 2+ inflow. Biochim Biophys Acta 1989: 1013: 197-205.
9. 2+ channels. Biochem Pharmacol 1986: 35: 3045-3052.
10. POGGIOLI J, MAUGER J P, GUESDON F, CLARET M. A regulatory calcium-binding site for calcium channel in isolated rat hepatocytes. J Biol Chem 1985: 260: 3289-3294.
11. MAUGER J P, CLARET M. Calcium channels in hepatocytes. J Hepatol 1988: 7: 278-282.
12. LANDON E J, JAISWAL R K, NAUKAM R J, SASTRY B V R. Effects of calcium channel blocking agents on membrane microviscosity and calcium in the liver of the carbon tetrachloride treated rat. Biochem Pharmacol 1984: 33: 3553-3560.
13. LIEBER C S. Mechanism of ethanol induced hepatic injury. Pharmacol Ther 1990: 46: 1-41.
14. LAMB R G, KOCH J C, SNYDER J W, HUBAND S M, BUSH S R. An in vitro model of ethanol-dependent liver cell injury. Hepatology 1994: 19: 174-182.
15. HOEK J B, THOMAS A P, RUBIN R, RUBIN E. Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes. J Biol Chem 1987: 262: 682-691.
16. RUBIN R, HOEK J B. Ethanol-induced stimulation of phosphoinositide turnover and calcium influx in isolated hepatocytes. Biochem Pharm 1988: 37: 2461-2466
17. i and inositol (1, 4, 5) triphosphate in rat hepatocytes. Biochem Biophys Res Commun 1990: 173: 774-780.
18. HISSIN P T, HILF R A Fluorimetric method for determination of oxidized and reduced glutathione in tissues Analyt Biochem 1976: 34: 214-226.
19. OTTOLENGHI A. Interaction of ascorbic acid and mitochondrial lipids. Arch Biochem Biophys 1958. 78. 355-361.
20. HOEK J B, TARASCHI T F. Cellular adaptation to ethanol. TIBS 1988: 13: 269-274.
21. THURMAN R G, APEL E, BADR M, LEMASTERS J L. Protection of liver by calcium entry blockers. Ann NY Acad Sci 1988: 522: 757-770.
22. ROMERO G, LASHERAS B, SAINZ L, CENARRUZABEITIA E. Protective effects of calcium channel blockers in carbon tetrachloride-induced liver toxicity. Life Sci 1994: 55: 981-990.
23. SIPPEL H, STAUFFERT I, ESTLER C J. Protective effect of various calcium antagonists against an experimentally induced calcium overload in isolated hepatocytes. Biochem Pharmacol 1993: 46. 1937-1944.
24. 2+ by diltiazem in rats with liver ischemia. J Hepatol 1994: 21: 567-571.
25. LIANG D C, THURMAN R G. Protective effects of the calcium antagonists diltiazem and TA3090 against hepatic injury due to hipoxia. Biochem Pharmacol 1992: 44. 2207-2211.
26. SHAW S, RUBIN K P, LIEBER C S. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: evidence of lipid peroxidation. Dig Dis Sci 1983: 28: 585-589.
27. CASTILLO T, KOOP D R, KAMIMURA S, TRIADAFILOPOULOS G, TSUKAMOTO H. Role of cytochrome P450 2E1 in ethanol-, carbontetrachloride-, and iron-dependent microsomal lipid peroxidation. Hepatohgy 1992: 16. 992-996.
28. HIRANO T, KAPLOWITZ N, TSUKAMOTO H, KAMIMURA S, FERNANDEZ-CHECA J C. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992: 6: 1423-1427.
29. 2+ influx at the plasma membrane: voltage-, receptor-, and second messengers-operated channels. Exp Cell Res 1987: 171: 271-283.
30. 2+ oscillations induced by hormonal stimulation of individual fura-2-loaded hepatocytes. J Biol Chem 1989: 264: 12859-12866.
31. BAFFY G, YANG L Y, MICHALOPOULOS G K, WILLIAMSON J R. Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes. J Cell Physiol 1992: 153: 332-339.
32. TANAKA Y, HAYASHI N, KANENO A, ITO T, MIYOSHI E, SASAKI Y. Epidermal growth factor induces dose-dependent calcium oscillations in single fura-2-loaded hepatocytes. Hepatology 1992: 16: 479-86.
33. STRIGGOW F, BOHNENSACK R. Verapamil and diltiazem inhibit receptor-operated calcium channels and intracellular calcium oscillations in rat hepatocytes. FEBS 1993: 318: 341-344.
34. MICHAEL A D, WHITING R L. Cellular action of nicardipine. Am J Cardiol 1989: 64: 3H-7H.
35. MATSUDA S. Protective effects of calcium antagonist (nitrendipine) on calcium ionophore A 23187-induced liver cell injury. Bull Tokyo Med Dent Univ 1991: 38: 35-44.
36. STEIN H J, OOSTHUIZEN M M, HINDER R A. Effect of verapamil on hepatic ischaemic-reperfusion injury in normal and glutathione-depleted rats. Gastroenterology 1989: 96: A663 (abstr.).
37. WU J, DANIELSSON A, LINDSTRÖM P, KARLSSON K, SEHLIN J. Protective effects of calcium channel blockers on acute bromobenzene toxicity to isolated rat hepatocytes. Inhibition of phenylephrine-induced calcium oscillations. Scand J Gastroenterol 1995: 30: 590-600.