Discontinuation of antihypertensive therapy: Prevalence of relapses and predictors of successful withdrawal in a hypertensive community

Cardiology (Switzerland)

Volumn 88, Issue 3, 1997, Pages 277-284

  Schmieder, Roland E ^a   Rockstroh, Jürgen K ^b   Gatzka, Christoph D ^a   Riiddel, Heinz ^b   Schächinger, Hartmut ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Antihypertensive therapy; Arterial hypertension; Essential hypertension; Hypertension; Predictors; Redevelopment

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CLONIDINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; METOPROLOL; NITRENDIPINE; OXPRENOLOL;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BORDERLINE HYPERTENSION; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; CLINICAL TRIAL; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; ERGOMETRY; ESSENTIAL HYPERTENSION; EXERCISE TEST; HEART LEFT VENTRICLE MASS; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RELAPSE; VASCULAR RESISTANCE;

EID: 0030991028     PISSN: 00086312     EISSN: 14219751     Source Type: Journal    
DOI: 10.1159/000177343     Document Type: Article

References (30)

1. MacMahon S. Ivto R, Culler J. et al: Blood pressure, stroke, and coronary heart disease. I. Prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias. Lancet 1990:335:765-774.
2. Joint National Committee: The 5th Report of the Joint National Committee on detection, evaluation, and treatment for high blood pressure (JNC V). Arch Intern Med 1993:153:154-183.
3. Page IH, Dustan HP: Persistence of normal blood pressure alter discontinuing treatment in hypertensive patients. Circulation 1962:25: 433-436.
4. Schmieder RE. Rockstroh JK. Messerli FH: Antihypertensive therapy-To stop or not to stop? JAMA 1991;265:1566-1571.
5. Schmieder RE, Gatzka C. Klingbeil A. Rilddel H. Schachinger H. Tcnes-Reino S: Obese hypertensive patients are less effectively treated than lean hypertensives. J Hypcrtens 1993; 1 (suppl 5):S348-S349.
6. Schmieder RE. Rüddel H. Ncus H. Messerli FH. Eiff AW: Disparate hemodynamic responses to mental challenge after antihypertensive therapy with beta blockers and calcium entry blockers. Am J Med 1987:82:11-16.
7. Schmieder RE. Bahr M. Langewitz W. Riiddel H. Schächinger H. Schulte W: Efficacy of four antihypertensive drugs (clonidine. enalapril. nitrendipine, oxprenolol) on stress blood pressure. Am J Cardiol 1989:63:1333-1338.
8. Noftke HU. Schirmer GE: Indirekte Blutdruckmessungen mit einem Zwcisondcnultra-schallsystem. Biomed Tech (Berlin) 1981:26: 162-167.
9. Kubicek WG. Kottkc FJ. Ramos MU: A Minnesota impedance cardiograph. Theor Appl Biomed M 1974:9:410-416.
10. Schmieder R. Rüddel H, Schächinger H, Ncus H: Psychophysiological aspects in essential hypertension. How to perform mental stress tests. J Hum Hypcrtens 1987:1:223-228.
11. Rüddel H. Bahr M. Langewitz W. Schächinger H. Schmieder R. Schulte W: Efficacy of longterm antihypertensive therapy with enalapril. Nephron 1990:55(suppl 1):77-80.
12. Schulte W. Rüddel H. Schmieder R. v Eiff AW: Hemodynamics and neurohumoral effects of low-dose clonidine in mild to moderate hypertension. J Cardiovasc Pharmacol 1987; 10(suppl 12): 152-156.
13. SAS User’s Guide: Statistics Version, cd 5. Carry, SAS Institute. 1985, pp 1-956.
14. Maland LJ. Lutz LJ. Castle CH: Effects of withdrawing diuretic therapy on blood pressure in mild hypertension. Hypertension 1983:5:539-544.
15. Levinson PD. Khatri IN. Freis ED: Resistance of normal BP after withdrawal of drug treatment in mild hypertension. Arch Intern Med 1982:142:2265-2268.
16. Hansen AG, Jensen H, Langcsen LP. Petersen A: Withdrawal of antihypertensive drugs in the elderly. Acta Med Scand 1983:676(suppl 2): 178-185.
17. Alderman MH. Davis T. Gerber LM, Robb M: Antihypertensive drug therapy withdrawal in a general population. Arch Intern Med 1986:146: 1309-1311.
18. Mitchell A. Haynes RB. Adsctt A. Bcllissimo A. Wilczynski N: The likelihood of remaining normotensive following antihypertensive drug withdrawal. J lntem Med 1989;4:221-225.
19. Jennings GL, Korner PL Läufer E. Ester MD. Burton D. Bruce A: How hypertension redevelops after sustation of long-term therapy. J Hy-pertens 1984:2(suppl 3):217-219.
20. Schmieder R. Rüddel H. Neus H. Neus J. Schulte W: Predictors of BP increases after withdrawal of antihypertensive therapy. J Hy-pertens 1985;3(suppl 3):457-459.
21. Langford HG. Blaufox MD, Obermann A. et al: Dietary therapies slow the return of hypertension after stopping prolonged medication. JAMA 1985:253:657-664.
22. Veterans Administration Cooperative Study Group on Antihypertensive Agents: Return of elevated blood pressure after withdrawal of an-tihvpcrtensive drugs. Circulation 1975:51: 1107-1113.
23. Dannenbcrg AL, Kannel WB: Remission of hypertension. The natural history of blood pressure treatment in the Framingham Study. JAMA 1987:257:1477-1483.
24. Frohlich ED, Kozul VJ. Tarazi RC. Dustan HP: Physiological comparison of labile and essential hypertension. Circ Res 1970:20(suppl I):55-63.
25. Messerli FH. Frohlich ED, Suarez DH. et al: Borderline hypertension: Relationship between age, hemodynamics and circulating catecholamines. Circulation 1981:64:760-764.
26. Christensen KL. Jespersen LT. Mulvany MJ: Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-lerm treatment related to vascular structure. J Hypertcns 1989;7:83-90.
27. Adams MA. Bobik A. Korner PI: Enalapril induces regression of vascular structure in spontaneously hypertensive rats and attenuates redevelopment of blood pressure when treatment is withdrawn (abstract). J Hypertcns 1989;7(suppl 6):35l.
28. Devcreux RB, Savage DD. Draver JIM. Laragh JH: Relation of hemodynamic load to left ventricular hypertrophy and performance in hypertension. Am J Cardiol 1983:51:171-176.
29. Langford HG. Blaufox MD. Oberman A. et al: Dietary therapy slows the return of hypertension after stopping prolonged medication. JAMA 1985:253:657-664.
30. Stamlcr R. Stamler J. Grimm R, et al: Nutritional therapy for high blood pressure: Final report of a 4-year randomized controlled trial-The Hypertension Control Program. JAMA 1987:257:1484-1491.