Role of vagus nerves and gastrin in the gastric phase of acid secretion in male anesthetized rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 2 35-2, 1997, Pages

  Noto, Tsunehisa ^a   Nagasaki, Masaaki ^a   Endo, Toshio ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

distension; peptone; vagotomy

Indexed keywords

4 [[2 [2 [[(2 ADAMANTYLOXY)CARBONYL]AMINO] 3 (1H INDOL 3 YL) 2 METHYLPROPIONAMIDO] 1 PHENYLETHYL]AMINO] 4 OXOBUTYRIC ACID MEGLUMINE; GASTRIN; PEPTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GASTRIN BLOOD LEVEL; MECHANICAL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION; STOMACH ACID SECRETION; STOMACH DISTENSION; VAGOTOMY; VAGUS NERVE;

EID: 0030990152     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.2.g335     Document Type: Article

References (27)

1. Alumets, J., M. Ekelund, R. Hakanson, J. Hedenbro, J. F. Rehfeld, F. Sundler, and S. Vallgren. Gastric acid response to pylorus ligation in rats: is gastrin or histamine involved? J. Physiol. Lond. 323: 145-156, 1982.
2. Andersson, S., and M. I. Grossman. Effect of vagal denervation of pouches on gastric secretion in dogs with intact or resected antrums. Gastroenterology 48: 449-462, 1965.
3. Blair, A. J., C. T. Richardson, J. H. Walsh, P. Chew, and M. Feldman. Effect of parietal cell vagotomy on acid secretory responsiveness to circulating gastrin in humans. Relationship to postprandial serum gastrin concentration. Gastroenterology 90: 1001-1007, 1986.
4. Blair, A. J. D., C. T. Richardson, J. H. Walsh, and M. Feldman. Variable contribution of gastrin to gastric acid secretion after a meal in humans. Gastroenterology 92: 944-949, 1987.
5. Debas, H. T., S. J. Konturek, J. H. Walsh, and M. I. Grossman. Proof of a pyloro-oxyntic reflex for stimulation of acid secretion. Gastroenterology 66: 526-532, 1974.
6. Esplugues, J. V., M. D. Barrachina, and J. Esplugues. Modulation by peripheral opioids of basal and distension-stimulated gastric acid secretion in the rat. Br. J. Pharmacol. 106: 33-38, 1992.
7. Esplugues, J. V., E. G. Ramos, L. Gil, and J. Esplugues. Influence of capsaicin-sensitive afferent neurones on the acid secretory responses of the rat stomach in vivo. Br. J. Pharmacol. 100: 491-496, 1990.
8. Feldman, M., R. M. Dickerman, R. N. McClelland, K. A. Cooper, J. H. Walsh, and C. T. Richardson. Effect of selective proximal vagotomy on food-stimulated gastric acid secretion and gastrin release in patients with duodenal ulcer. Gastroenterology 76: 926-931, 1979.
9. Grossman, M. I. Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs. Gastroenterology 42: 718-721, 1962.
10. Hakanson, R., J. Hedenbro, G. Liedberg, F. Sundler, and S. Vallgren. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. J. Physiol. Lond. 305: 139-149, 1980.
11. Hakanson, R., J. Hedenbro, G. Liedberg, and S. Vallgren. Effect of vagotomy on gastric acid secretion in the rat. Acta Physiol. Scand. 115: 135-139, 1982.
12. Hayward, N. J., M. Harding, S. A. Lloyd, A. T. McKnight, J. Hughes, and G. N. Woodruff. The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat. Br. J. Pharmacol. 104: 973-977, 1991.
13. Hughes, J., P. Boden, B. Costall, A. Domeney, E. Kelly, D. C. Horwell, J. C. Hunter, R. D. Pinnock, and G. N. Woodruff. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc. Natl. Acad. Sci. USA 87: 6728-6732, 1990.
14. Kleveland, P. M., S. E. Haugen, S. Sandvik, and H. L. Waldum. The effect of pentagastrin on the gastric secretion by the totally isolated vascularly perfused rat stomach. Scand. J. Gastroenterol. 21: 379-384, 1986.
15. Kovacs, T. O., J. H. Walsh, V. Maxwell, H. C. Wong, T. Azuma, and E. Katt. Gastrin is a major mediator of the gastric phase of acid secretion in dogs: proof by monoclonal antibody neutralization. Gastroenterology 97: 1406-1413, 1989.
16. Li, Y., and C. Owyang. Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats. Gastroenterology 107: 525-531, 1994.
17. Lloyd, K. C., H. E. Raybould, Y. Tache, and J. H. Walsh. Role of gastrin, histamine, and acetylcholine in the gastric phase of acid secretion in anesthetized rats. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G747-G755, 1992.
18. Lloyd, K. C., and J. H. Walsh. Regulation of acid secretion in vivo. In: Gastrin, edited by J. H. Walsh. New York: Raven, 1993, p. 221-242.
19. Manela, F. D., W. S. Dyer, J. Ren, and R. F. Harty. Validation of the antral mucosal/submucosal sleeve preparation: studies of gastrin and acetylcholine release in response to luminal stimulation. Life Sci. 51: 1363-1372, 1992.
20. Nishida, A., K. Miyata, R. Tsutsumi, H. Yuki, S. Akuzawa, A. Kobayashi, T. Kamato, H. Ito, M. Yamano, Y. Katuyama, N. Satoh, M. Ohta, and K. Honda. Pharmacological profile of (R)-1-[2,3-dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo. J. Pharmacol. Exp. Ther. 269: 725-731, 1994.
21. Ramos, E. G., J. Esplugues, and J. V. Esplugues. Gastric acid secretory responses induced by peptone are mediated by capsaicin-sensitive sensory afferent neurons. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G835-G839, 1992.
22. Raybould, H. E., and Y. Tache. Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized rats. Eur. J. Pharmacol. 167: 237-243, 1989.
23. Roland, M., A. Berstad, and I. Liavag. Acid and pepsin secretion in duodenal ulcer patients in response to graded doses of pentagastrin or pentagastrin and carbacholine before and after proximal gastric vagotomy. Scand. J. Gastroenterol. 9: 511-518, 1974.
24. Schubert, M. L., D. H. Coy, and G. M. Makhlouf. Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G685-G689, 1992.
25. Schubert, M. L., and G. M. Makhlouf. Gastrin secretion induced by distention is mediated by gastric cholinergic and vasoactive intestinal peptide neurons in rats. Gastroenterology 104: 834-839, 1993.
26. Van de Brug, F. J., J. B. Jansen, R. J. Kuijpers, and C. B. Lamers. Inhibition of meal-stimulated gastric acid secretion by gastrin immunoneutralization in rats. Eur. J. Pharmacol. 198: 197-201, 1991.
27. Varga, G., D. R. Campbell, L. J. Bussjaeger, and T. E. Solomon. Role of gastrin and cholecystokinin receptors in regulation of peptone-stimulated gastric acid secretion in conscious rats. Eur. J. Pharmacol. 250: 37-42, 1993.