Effect of ammonia on motor function in adult rats

Brain Research Bulletin

Volumn 43, Issue 3, 1997, Pages 275-278

  Jayakumar, A R ^a   Sujatha, R ^a   Paul, Vanaja ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Brain ammonia; Brain glucose; Convulsions; Motor coordination; Spontaneous motor activity

Indexed keywords

AMMONIA; AMMONIUM ACETATE; AMMONIUM CHLORIDE; GLUCOSE;

AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE UTILIZATION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETATES; AMMONIUM CHLORIDE; ANIMALS; BRAIN; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR;

EID: 0030990110     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(96)00432-7     Document Type: Article

References (28)

1. Banister F. W., Cameron R. L. Exercise-induced hyperammonemia: Peripheral and central effects. Int. J. Sports Med. 2:1990;S129-S142.
2. Blei A. T., Olafsson S., Therrien G., Butterworth R. F. Ammonia induced brain edema and intracranial hypertension in rats after portacaval anastomosis. Hepatology. 19:1994;1437-1444.
3. Butterworth R. F., Giguere J. F., Michaud J., Lavoie J., Layrargues P. G. Ammonia: Key factor in the pathogenesis of hepatic encephalopathy. Neurochem. Pathol. 6:1987;1-12.
4. Cohn R., Castell D. O. The effects of acute hyperammonemia on the electroencephalogram. J. Lab. Clin. Med. 68:1966;195-205.
5. Cole M., Rutherford R. B., Owen Smith F. Experimental ammonia encephalopathy in the primate. Arch. Neurol. Chicago. 26:1972;130-136.
6. Cooper A. J. L., Mora S. N., Cruz N. F., Gelbard A. S. Cerebral ammonia metabolism in hyperammonemia rats. J. Neurochem. 44:1985;1716-1723.
7. Cruz N. F., Dienel G. A. Brain glucose levels in portacaval-shunted rats with chronic, moderate hyperammonemia: Implications for determination of local cerebral glucose utilization. J Cereb. Blood Flow Metab. 14:1994;113-124.
8. Dunham N. W., Miya T. S. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharmaceut. Assoc. Sci. Ed. XIVI:1957;208-209.
9. Eichler M. Psychological changes associated with induced hyperammonemia. Science. 144:1964;886-888.
10. Gebhardt R., Reichen J. Changes in distribution and activity of glutamine synthetase in carbon tetrachloride-induced cirrhosis in the rat: Potential role in hyperammonemia. Hepatology. 20:1994;684-691.
11. Hawkins R. A., Jessy J., Mans A. M., De Joseph M. R. Effects of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopthy. J. Neurochem. 60:1993;1000-1006.
12. Iles J. F., Jack J. J. B. Ammonia: Assessment of its action on postsynaptic inhibition as a cause of convulsions. Brain. 103:1980;555-578.
13. Jayakumar A. R., Sujatha R., Paul V. Colorimetric determination of blood and brain ammonia. Ind. J. Biochem. Biophys. 33:1996;231-233.
14. Jessy J., Murthy Ch. R. K. Elevation of transamination of branched chain amino acids in brain in acute ammonia toxicity. Neurochem. Int. 7:1985;1027-1031.
15. Kelleher J. A., Gregory G. A., Chan P. H. Effect of fructose-1, 6-biphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures. Neurochem. Res. 19:1994;209-215.
16. Llinas R., Baker R., Precht W. Blockade of inhibition by ammonium acetate: Action on chloride pump in cat trochlear motoneurons. J. Neurophysiol. 37:1974;522-532.
17. Lockwood A. H., Ginsberg M. D., Butler C. M., Gutierrez M. T. Selective effects of ammonia on regional brain glucose metabolism (abstr). Ann. Neurol. 12:1982;114.
18. Lux H. D., Loracher C., Neher E. The action of ammonium in postsynaptic inhibition of cat spinal motoneurons. Exp. Brain Res. 11:1970;431-447.
19. Mans A. M., DeJoseph M. R., Hawkins R. A. Metabolic abnormalities and grade of encephalopthy in acute hepatic failure. J. Neurochem. 63:1994;1829-1838.
20. McCandless D. W., Schenker S. Effect of acute ammonia intoxication on energy stores in the cerebral reticular activating system. Exp. Brain Res. 44:1981;325-330.
21. Okamura K., Matsubara F., Yoshioka Y., Kikuchi N., Kikuchi Y., Kohri H. Exercise-induced changes in branced chain amino acid/aromatic amino acid ratio in the rat brain and plasma. Jpn. J. Pharmacol. 45:1987;243-248.
22. Paul V., Balasubramaniam E., Kazi M. The nuerobehavioral toxicity of endosulfan in rats: A serotonergic involvement in learning impairment. Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Sect. 270:1994;1-7.
23. Raabe W., Gumnit R. J. Disinhibition in cat motor cortex by ammonia. J. Neurophysiol. 38:1975;347-355.
24. Rao V. L. R., Murthy Ch. R. K., Butterworth R. F. Glutamatergic synaptic dysfunction in hyperammonemic syndromes. Metab. Brain Dis. 7:1992;1-20.
25. Rukmini Devi R. P., Murthy Ch. R. K. Ammonia-induced alterations in the activities of synaptosomal cholinesterases of rat brain under in vitro and in vivo conditions. Neurosci. Lett. 159:1993;131-134.
26. Sasaki T., Matsuy S., Sanae A. Effect of acetic acid concentration on the colour reaction in the o-toluidine-boric acid method for blood glucose determinations. Rinsho Kagaku. 1:1972;346-353.
27. Subbalakshmi G. Y. C. V., Murthy Ch. R. K. Differential response of enzymes of glutamate metabolism in neuronal perikarya and synaptosomes in acute hyperammonemia in rat. Neurosci. Lett. 59:1985;121-126.
28. Tsukada Y. Ammonia metabolism. Lajtha A. Handbook of neurochemistry. 5A:1971;215-233 Plenum Press, New York.