Short-term exercise training enhances reflex cholinergic nitric oxide- dependent coronary vasodilation in conscious dogs

Circulation Research

Volumn 80, Issue 6, 1997, Pages 868-876

  Zhao, Gong ^a   Zhang, Xiaoping ^a   Xu, Xiaobin ^a   Ochoa, Manuel ^a   Hintze, Thomas H ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

adenosine; Bezold Jarisch reflex; exercise training; nitric oxide; nitro L arginine

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ANGIOTENSIN; BRADYKININ; NITRIC OXIDE; NITRO DERIVATIVE; NORADRENALIN;

ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR REFLEX; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; EXERCISE; HEMODYNAMICS; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; VAGUS NERVE;

EID: 0030989850     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.80.6.868     Document Type: Article

References (30)

1. Leon AS, Blood CM. Effects of exercise and its cessation on the heart and its blood supply. J Appl Physiol. 1998;24:484-490.
2. Blood CM, Leon AS. Interaction of age and exercise on the heart and its blood supply. Lab Invest. 1970;22:160-165.
3. Laughlin MH, Diana JN, Tipton CM. Effects of exercise training on coronary reactive hyperemia and blood flow in the dog. J Appl Physiol 1978;45:604-610.
4. Kramsch DM, Aspen AJ, Abramowitz BM, Kreimendahl T, Hood WB Jr. Reduction of coronary atherosclerosis by moderate conditioning exercise in monkey on an atherogenic diet. N Engt J Med. 1981;305:1483-1489.
5. Schaible TF, Scheuer J. Cardiac adaptations to chronic exercise. Prog Cardivasc Dis. 1985;27:297-324.
6. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-376.
7. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
8. Delp MD, McAllister RM, Laughlin MH. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol. 1993;75:1354-1363.
9. Muller JM, Myers PR, Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 1994;89:2308-2314.
10. Delp MD, McAllister RM, Laughlin MH. Exercise training alters aortic vascular reactivity to hypothyroid rats. Am J Physiol. 1995; 268:H1428-H1435.
11. Sun D, Huang A, Koller A, Kaley C. Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats. J Appl Physiol 1994;76:2241-2247.
12. Koller A, Huang A, Sun D, Kaley G. Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles: role of endothelial nitric oxide and prostaglandins. Circ Res. 1995;76: 544-550.
13. Wang J, Wolin MS, Hintze TH. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res. 1993;73:829-838.
14. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dugs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994;74:349-353.
15. Shen WQ, Ochoa M, Xu XB, Wang J, Hintze TH. Role of EDRF/NO in parasympathetic coronary vasodilation following carotid chemoreflex activation in conscious dogs. Am J Physiol. 1994;267:H605-H613.
16. Zhao G, Shen WQ, Xu XB, Ochoa M, Bernstein R, Hintze TH. Selective impairment of vagally mediated, nitric oxide-dependent coronary vasodilation in conscious dogs after pacing-induced heart failure. Circulation 1995;91:2655-2663.
17. Smith CJ, Sun D, Hoegler C, Roth BS, Zhang X, Zhao G, Xu X-B, Kobari Y, Pritchard K Jr, Sessa WC, Hintze TH. Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 to heart failure. Circ Res. 1996;78:58-64.
18. Liang IYS, Stone HL. Effect of exercise conditioning on coronary resistance. J Appl Physiol. 1982;53:631-636.
19. Hintze TH, Vatner SF. Reactive dilation of large coronary arteries in conscious dogs. Circ Res. 1984;54:50-57.
20. Gerritsen ME, Printz M. Sites of prostaglandin synthesis in the bovine heart and isolated coronary microvessels. Circ Res. 1981;49: 1152-1163.
21. Seyedi N, Xu XB, Nasjletti A, Hintze TH. Local kinin generation mediates the formation of NO following angiotensin I and II receptor stimulation in canine coronary microvessels and large arteries. Hypertension. 1995;26:164-170.
22. Feigl EO. Reflex parasympathetic coronary vasodilaiion elicited from cardiac receptors in the dog. Circ Res. 1975;37:175-182.
23. Zucker IH, Cornish KG, Hackley J, Bliss K. Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs. Circ Res l987;61(Suppl II):II-54-II-60.
24. Wyatt HL, Mitchell J. Influences of physical conditioning and deconditioning on coronary vasculature of dogs. J Appl Physiol. 1978;45:619-625.
25. Oltman CL, Parker JL, Adams HR, Laughlin MH. Effects of exercise training on vasomotor reactivity of porcine coronary arteries. Am J Physiol. 1992;263:H372-H382.
26. DiCarlo SE, Blair RW, Bishop VS, Stone HL. Daify exercise enhances coronary resistance vessel sensitivity to pharmacological activation. J Appl Physiol. 1989;66:421-428.
27. Feigl EO. Parasympathetic control of coronary blood flow. Fed Proc. 1984;43:2881-2883.
28. Broten TP, Miyashiro JK, Moncada S, Feigl EO. Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation. Am J Physiol. 1992;262:H1579-H1584.
29. Zucker IH. Left ventricular receptors: physiological controllers or pathological curiosities? Basic Res Cardiol. 1986;81:S39-S57.
30. Hornig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 1996;93:210-214.