Importance of cerebral blood flow to the recognition of and physiological responses to hypoglycemia

Diabetes

Volumn 46, Issue 5, 1997, Pages 829-833

  Thomas, Matthew ^a   Sherwin, Robert S ^b   Murphy, June ^a   Kerr, David ^a  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENERGIC STIMULATION; ADULT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; COGNITION; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; HYPOGLYCEMIA; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030989781     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.5.829     Document Type: Article

References (29)

1. Mitrakou A, Ryan C, Veneman C, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J: Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms and cerebral dysfunction. Am J Physiol 260:E67-E74, 1991
2. Neil HAW, Gale EAM, Hamilton SJC, Lopez-Espinoza I, Kaura R, McCarthy ST: Cerebral blood flow increases during insulin-induced hypoglycaemia in type 1 (insulin-dependent) diabetic patients and control subjects. Diabetologia 30:305-309, 1987
3. Debrah K, Sherwin R, Murphy J, Kerr D: Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. Lancet 347:19-24, 1996
4. Kerr D, Sherwin RS, Pavalkis F, Fayad P, Sikorski L, Rife F, Tamborlane WV, During MJ: Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Ann Intern Med 119:799-804, 1993
5. Brown MM, Wade JPH, Bishop CCR, Russell RWR: Reactivity of the cerebral circulation in patients with carotid occlusion. J Neurol Neurosurg Psychiatry 49:899-904, 1986
6. Bonte FJ, Devous MD, Reisch J: The effect of acetazolamide on regional cerebral blood flow in normal human subjects as measured by single-photon emission tomography. Invest Radiol 8:564-568, 1988
7. Aaslid R, Markwalder TM, Nornes H: Noninvasive transcutaneous Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:739-744, 1984
8. Kontos HA: Validity of cerebral arterial blood flow calculations from velocity measurements. Stroke 20:1-3, 1989
9. Kerr D, Stanley JC, Barron M, Thomas R, Leatherdale BA, Pickard J: Symmetry of cerebral blood flow and cognitive responses to hypoglycaemia in humans. Diabetologia 36:73-76, 1993
10. Skiare DA, Lynn GE: Latency of the P3 event-related potential: normative aspects and within-subject variability. Electroenceph Clin Neurophysiol 59:420-440, 1984
11. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
12. Matthews JNS, Altman DG, Campbell MJ, Royston P: Analysis of serial measurements in medical research. Br Med J 300:230-235, 1990
13. Tallroth G, Ryding E, Agardh CD: The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36:530-535, 1993
14. Pardridge WM, Boado RJ, Farrell CR: Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain-barrier: studies with quantitative Western blotting and in situ hybridization. J Biol Chem 265:18035-18040, 1990
15. Lund-Anderson H: Transport of glucose from blood to brain. Physiol Rev 59:305-352, 1979
16. McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB: Chronic hypoglycemia increases brain glucose transport. Am J Physiol 251:E442-E447, 1986
17. Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI: Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 93:1677-1682, 1994
18. Tallroth G, Ryding E, Agardh CD: Regional cerebral blood flow in normal man during insulin-induced hypoglycemia and in the recovery period following glucose infusion. Metabolism 41:717-721, 1992
19. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K: Cerebral vasoreactivity: simultaneous assessment by transcranial Doppler and rCBF studies. J Cereb Blood Flow Metab 9:364-366, 1989
20. Dahl A, Lindegaard KF, Russell D, Nyberg-Hansen R, Rootwelt K, Sorteberg W, Nornes H: A comparison of transcranial Doppler and cerebral blood flow studies to assess cerebral vasoreactivity. Stroke 23:15-19, 1992
21. Dahl A, Russell D, Rootwelt K, Nyberg-Hansen R, Kerty E: Cerebral vasoreactivity assessed with transcranial Doppler and regional cerebral blood flow measurements. Stroke 26:2302-2306, 1995
22. Vorstrup S, Henriksen L, Paulson OB: Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. J Clin Invest 74:1634-1639, 1984
23. Frankel HM, Garcia E, Malik F, Weiss JK, Weiss HR: Effect of acetazolamide on cerebral blood flow and capillary patency. J Appl Physiol 73:1756-1761, 1992
24. Hollinger BR, Bryan RM: β-receptor mediated increase in cerebral blood flow during hypoglycaemia. Am J Physiol 253:H949-H955, 1987
25. Bouma GD, Muizelaar JP: Relationship between cardiac output and cerebral blood flow in patients with intact and with impaired cerebral autoregulation. J Neurosurg 73:368-374, 1990
26. Powers WJ, Boyle PJ, Hirsch IB, Cryer PE: Unaltered cerebral blood flow during hypoglycemic activation of the sympathochromaffin system in humans. Am J Physiol 265:R883-R887, 1993
27. Boyle PJ, Nagy R, O'Connor AM, Kempers SF, Yeo RA, Quails C: Adaptation in brain glucose uptake following recurrent hypoglycemia Proc Natl Acad Sci USA 91:9352-9356, 1994
28. Boyle PJ, Kempers SF, O'Connor AM, Nagy RJ: Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus.N Engl J Med 333:1726-1731, 1995
29. Draelos MT, Jacobson AM, Weinger K, Widom B, Ryan CM, Finkelstein DM, Simonson DC: Cognitive function in patients with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia. Am J Med 98:135-144, 1995