Acquired resistance to Borrelia burgdorferi infection in the rabbit: Comparison between outer surface protein A vaccine- and infection-derived immunity

Journal of Clinical Investigation

Volumn 99, Issue 8, 1997, Pages 2030-2035

  Foley, Denise M ^a   Wang, Yi Ping ^a   Wu, Xiao Yang ^a   Blanco, David R ^a   Lovett, Michael A ^a   Miller, James N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Lyme borreliosis; protective immunity; rabbit model; spirochete; vaccinogens

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BORRELIA BURGDORFERI; BORRELIA INFECTION; CONTROLLED STUDY; IMMUNOSTIMULATION; INFECTION RESISTANCE; LYME DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0030989515     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119371     Document Type: Article

References (42)

1. Lyme disease surveillance-United States. 1989-1990. MMWR (Morb. Mort. Wkly. Rep.). 1991; 40:417-421.
2. Burgdorfer, W., A.C. Barbour, S.F. Hayes, J.L. Benach, E. Grunwaldt, and J.P. Davis. 1982. Lyme disease - a tickborne spirochetosis? Science (Wash. DC). 216:1317-1319.
3. Steere, A.C. 1989. Lyme disease. N. Engl. J. Med. 321:586-596.
4. Steere, A.C., S.E. Malawista, J.A. Hardin, S. Ruddy, P.W. Askenase, and W.A. Andiman. 1977. Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann. Intern. Med. 86:685-698.
5. Steere, A.C., R.L. Grodzicki, A.N. Kornblatt, J.E. Craft, A.G. Barbour, W. Burgdorfer, G.P. Schmid, E. Johnson, and S.E. Malawista. 1983. The spirochetal etiology of Lyme disease. N. Engl. J. Med. 308:733-740.
6. Stanek, G., J. Klein, R. Bittner, and D. Glogar. 1990. Isolation of Borrelia burgdorferi from the myocardium of a patient with longstanding cardiomyopathy. N. Engl. J. Med. 322:249-252.
7. Schmidli, J., T. Hunziker, P. Moesli, and U.B. Schaad. 1988. Cultivation of Borrelia burgdorferi from joint fluid 3 months after treatment of facial palsy due to Lyme borreliosis. J. Infect. Dis. 158:905-906.
8. Logigan, E.L., R.F. Kaplan, and A.C. Steere. 1990. Chronic neurologic manifestations of Lyme disease. N. Engl. J. Med. 323:1438-1444.
9. Pachner, A.R., and A.C. Steere. 1985. The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology. 35:47-53.
10. Steere, A.C., W.P. Batsford, and M. Weinberg. 1980. Lyme carditis: cardiac abnormalities of Lyme disease. Ann. Intern. Med. 93:8-16.
11. Steere, A.C., R.T. Schoen, and E. Taylor. 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107:725-731.
12. Ackerman, R., B. Rehse-Kupper, E. Gollmer, and R. Schmidt. 1988. Chronic neurologic manifestations of erythema migrans borreliosis. Ann. NY Acad. Sci. 539:16-23.
13. Pachner, A.R., P. Duray, and A.C. Steere. 1989. Central nervous system manifestations of Lyme disease. Arch. Neurol. 46:790-795.
14. Garcia-Monco, J.C., and J.L. Benach. 1989. The pathogenesis of Lyme disease. Rheum. Dis. Clin. N. Am. 15:711-726.
15. Fikrig, E., S.W. Barthold, F.S. Kantor, and R.A. Flavell. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (Wash. DC). 250:553-556.
16. Fikrig, E., S.W. Barthold, F.S. Kantor, and R.A. Flavell. 1992. Long term protection of mice from Lyme disease by vaccination with OspA. Infect. Immun. 60:773-777.
17. Fikrig, E., S.W. Barthold, N. Marcantonio, K. Deponte, F.S. Kantor, and R.A. Flavell. 1992. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 60:657-661.
18. Simon, M., U.E. Schaible, M.D. Kramer, C. Eckerskorn, C. Museteanu, H.K. Muller-Hermelink, and R. Wallich. 1991. Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J. Infect. Dis. 164:123-132.
19. Erdile, L.F., M. Brandt, D.J. Warakomski, G.J. Westrack, A. Sadziene, A.G. Barbour, and J.P. Mays. 1993. Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA. Infect. Immun. 61:81-90.
20. Coughlin, R.T., D. Fish, T.N. Mather, J. Ma, C. Pavia, and P. Bulger. 1995. Protection of dogs from Lyme disease with a vaccine containing outer surface protein A (OspA), OspB, and Saponin adjuvant QS21. J. Infect. Dis. 171: 1049-1052.
21. Fikrig, E., S.R. Telford III, S.W. Barthold, F.S. Kantor, A. Spielman, and R. Flavell. 1992. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc. Natl. Acad. Sci. USA. 89:5418-5421.
22. Kurtti, T.J., U.G. Munderloh, C.A. Norton Hughes, S.M. Engstrom, and R.C. Johnson. 1996. Resistance to tick-borne spirochete challenge induced by Borrelia burgdorferi strains that differ in expression of outer surface proteins. Infect. Immun. 64:4148-4153.
23. Preac-Mursic, V., B. Wilske, E. Patsouris, S. Jauris, G. Will, E. Soutschek, S. Reinhardt, G. Lehnert, U. Klockmann, and P. Mehraein. 1992. Active immunization with pC protein of Borrelia burgdorferi, protects gerbils against B. burgdorferi infection. Infection. 20:342-349.
24. Probert, W.S., and R.B. LeFebvre. 1994. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infect. Immun. 62:1920-1926.
25. Brusca, J.S., A.W. McDowell, M.V. Norgard, and J.D. Radolf. 1991. Localization of outer surface protein A and B in both the outer membrane and intracellular compartments of Borrelia burgdorferi. J. Bacteriol. 173:8004-8008.
26. Foley, D.M., R.J. Gayek, J.T. Skare, E.A. Wagar, C.I. Champion, D.R. Blanco, M.A. Lovett, and J.N. Miller. 1995. Rabbit model of Lyme borreliosis: erythema migrans, infection-derived immunity, and identification of Borrelia burgdorferi proteins associated with virulence and protective immunity. J. Clin. Invest. 96:965-975.
27. Barbour, A.G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
28. Schwan, T.G., W. Burgdorfer, M.E. Schrumpf, and R.H. Karstens. 1988. The urinary bladder: a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leocopus). J. Clin. Microbiol. 26: 893-895.
29. Philipp, M.T., M.K. Aydintug, R.P. Bohm, Jr., F.B. Cogswell, V.A. Dennis, H.N. Lanners, R.C. Lowrie, Jr., E.D. Roberts, M.D. Conway, M. Karacorlu, et al. 1993. Early and early disseminated phases of Lyme disease in the rhesus monkey: model for infection in humans. Infect. Immun. 61:3047-3059.
30. Fikrig, E., S.W. Barthold, D.H. Persing, X. Sun, F.S. Kantor, and R.A. Flavell. 1992. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J. Immunol. 148:2256-2260.
31. Luft, B.J., R.J. Dattwyler, R.C. Johnson, S.W. Luger, E.M. Bosler, D.W. Rahn, E.J. Masters, E. Grunwaldt, and S.D. Gadgil. 1996. Azithromycin compared with amoxicillin in the treatment of erythema migrans. A double-blind, randomized, controlled trial. Ann. Intern. Med. 124:785-791.
32. Johnson, B.J., S.L. Sviat, C.M. Happ, J.J. Dunn, J.C. Frantz, L.W. Mayer, and J. Piesman. 1995. Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2. Vaccine. 13:1086-1094.
33. Skare, J.T., E.S. Shang, D.M. Foley, D.R. Blanco, C.I. Champion, T. Marzabekov, Y. Sokolov, B.L. Kagan, J.N. Miller, and M.A. Lovett. 1995. Virulent strain associated outer membrane proteins of Borrelia burgdorferi. J. Clin. Invest. 96: 2380-2392.
34. Aydintug, M.K., Y. Gu, and M.T. Phillip. 1994. Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey. Infect. Immun. 62:4929-4937.
35. Schaible, U.E., L. Gern, R. Wallich, M.D. Kramer, M. Prester, and M.M. Simon. 1993. Distinct patterns of protective antibody are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen. Immunol. Let. 36:219-226.
36. Barthold, S.W., and L.K. Bockenstedt. 1993. Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect. Immun. 61: 4696-4702.
37. Schwan, T.G., J. Piesman, W.T. Golde, M.C. Dolan, and P.A. Rosa. 1995. Induction of an outer surface protein Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA. 92:2909-2913.
38. Barthold S.W., E. Fikrig, L.K. Bockenstedt, and D.H. Persing. 1995. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63:2255-2261.
39. Wilske, B., V. Preac-Mursic, U.B. Gobel, B. Graf, S. Jauris, E. Soutschek, E. Schwab, and G. Zumstein. 1993. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. J. Clin. Microbiol. 31:340-350.
40. Rosa, P.A., T. Schwan, and D. Hogan. 1992. Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi. 1992. Mol. Microbiol. 6:3031-3040.
41. Jonsson, M., L. Noppa, A.G. Barbour, and S. Bergstrom. 1992. Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of Osp operons of three isolates of different geographic origins. Infect. Immun. 60: 1845-1853.
42. Marconi, R.T., M.E. Konkel, and C.F. Garon. 1993. Variability of Osp genes and gene products among species of Lyme disease spirochetes. Infect. Immun. 61:2611-2617.