Comparison of the antinociception produced by two oral formulations of ibuprofen: Ibuprofen effervescent vs ibuprofen tablets

European Journal of Clinical Pharmacology

Volumn 52, Issue 2, 1997, Pages 107-114

  Hummel, T ^a,b   Cramer, O ^a   Mohammadian, P ^a   Geisslinger, G ^a   Pauli, E ^a   Kobal, G ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

analgesia; human; Ibuprofen; irritation; Nociception; NSAID

Indexed keywords

IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG FORMULATION; ELECTROENCEPHALOGRAM; EVOKED SOMATOSENSORY RESPONSE; FEMALE; HUMAN; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CONSCIOUS SEDATION; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; FEMALE; HUMANS; IBUPROFEN; MALE; NOCICEPTORS; PAIN; PLACEBOS; PSYCHOMOTOR PERFORMANCE; TABLETS;

EID: 0030989128     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050258     Document Type: Article

References (19)

1. Schettler T, Lange R (1993) Pharmakokinetik eines Ibuprofen-Brausegranulats im Vergleich zum Ibuprofen-Dragee. Pharm Ztg Wiss 138: 17-22
2. Hummel T, Huber H, Menzel S, Kobal G (1995) Tonic vs. phasic pain: Dose-related effects of ketoprofen. Eur J Clin Pharmacol 49: 7 14
3. Kobal G, Hummel C, Gruber M, Geisslinger G, Hummel T (1994) Dose-related effects of ibuprofen on pain-related potentials. Br J Clin Pharmacol 37: 445-452
4. Lötsch J, Geisslinger G, Mohammadian P, Brune K, Kobal G (1995) Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects. Br J Clin Pharmacol 40: 339-346
5. Lötsch J, Mohammadian P, Hummel T, Florin S, Brune K, Geißlinger G, Kobal G (1995) Effects of azapropazone on pain-related brain activity in human subjects. Br J Clin Pharmacol 40: 545-552
6. Kobal G, Hummel T (1992) Human electro-olfactograms and brain responses to olfactory stimulation. In: Laing DG, Doty RL, Breipohl W (eds) The human sense of smell. Springer-Verlag. Berlin Heidelberg New York, pp 135 151
7. Kobal G (1985) Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation. Pain 22: 151-163
8. Kobal G, Hummel C (1988) Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroenceph Clin Neurophysiol 71: 241-250
9. Hummel T, Huber H, Kobal G (1995) Comparison of analgesic effects of ibuprofen-lysinate and ibuprofen-acid. Pharmacol Comm 5: 101 108
10. Kobal G, Hummel C, Nürnberg B, Brune K (1990) Effects of pentazocine and acetylsalicylic acid on pain-rating, pain-related evoked potentials and vigilance in relationship to pharmaeokinetic parameters. Agents Actions 29: 342-359
11. Menzel-Soglowek S, Geisslinger G, Brune K (1990) Stereoselective high-performance liquid Chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using an alpha1-acid glycoprotein column. J Chromatogr 532: 295-303
12. Geisslinger G, Dietzel K, Bezler H, Nuernberg B, Brune K (1989) Therapeutically relevant differences in the pharmacokinetic and pharmaceutical behaviour of ibuprofen lysinate as compared to ibuprofen acid. Int J Clin Pharmac Ther Tox 27: 324-328
13. Chen ACN, Chapman RC, Harkins SW (1979) Brain evoked potentials are functional correlates of induced pain in man. Pain 6: 365-374
14. Hummel T, Livermore A, Hummel C, Kobal G (1992) Chemosensory event-related potentials: relation to olfactory and painful sensations elicited by nicotine. Electroenceph Clin Neurophysiol 84: 192 195
15. Livermore A, Hummel T, Kobal G (1992) Chemosensory evoked potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems. Electroenceph Clin Neurophysiol 83: 201-206
16. Guzman F, Braun C, Lim RKS, Potter GD, Rodgers DW (1964) Narcotic and non-narcotic analgesics which block visceral pain evoked by intra-arterial injection of bradykinin and other analgesic actions. Arch Int Pharmacodyn Ther 149: 571 588
17. Malmberg AB, Yaksh TL (1992) Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 257: 1276 1279
18. Gabka J, Weyerstahl T (1988) Klinisch-experimentelle Wirksamkeitsprüfung von Ibuprofen-Lysinat versus Ibuprofen. In: Herrmann M, Manz W, Kappel J (eds) Ibuprofen-Lysinat in Analgesie und Rheumatologie. Zuckerschwerdt Verlag, Munich, pp 44-48
19. Laska EM, Sunshine A, Marrero I, Olson N, Siegel C, McCormick N (1986) The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther 40: 1 7