Influence of alterations in forgoing life-sustaining treatment practices on a clinical sepsis trial

Critical Care Medicine

Volumn 25, Issue 3, 1997, Pages 383-387

  Sprung, Charles L ^a,g   Eidelman, Leonid A ^a   Pizov, Reuven ^a   Fisher Jr , Charles J ^b   Ziegler, Elizabeth J ^c   Sadoff, Jerald C ^d   Straube, Richard C ^e   McCloskey, Richard V ^f  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^e T Cell Sciences   (United States)

^f CENTOCOR INC   (United States)

^g HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

critical care; forgoing; intensive care unit; life sustaining; mortality; sepsis; treatments; trial; withdraw; withhold

Indexed keywords

HYPERTENSIVE AGENT; CENTOXIN; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL PRACTICE; DIALYSIS; HUMAN; INTUBATION; MAJOR CLINICAL STUDY; MORTALITY; PRIORITY JOURNAL; RESUSCITATION; SEPSIS; SURGERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DEATH AND EUTHANASIA; DECISION MAKING; DOUBLE BLIND PROCEDURE; EMPIRICAL APPROACH; EPIDEMIOLOGY; LONG TERM CARE; MIDDLE AGED; MULTICENTER STUDY; PASSIVE EUTHANASIA; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TIME;

DEATH AND EUTHANASIA; EMPIRICAL APPROACH;

ANTIBODIES, MONOCLONAL; BIAS (EPIDEMIOLOGY); DECISION MAKING; DOUBLE-BLIND METHOD; EUTHANASIA, PASSIVE; HOSPITAL MORTALITY; HUMANS; LIFE SUPPORT CARE; MIDDLE AGED; MULTICENTER STUDIES; PROGNOSIS; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; SEPSIS; TIME FACTORS;

EID: 0030989105     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199703000-00002     Document Type: Article

References (19)

1. Bone RC, Fisher CJ, Clemmer TP, et al: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317:653-658
2. VA Systemic Sepsis Cooperative Study Group: Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317:659-665
3. Ziegler EJ, Fisher CJ, Sprung CL, et al: Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med 1991; 324: 429-436
4. Greenman RL, Schein RMH, Martin MA, et al: A controlled clinical trial of E5 murine monoclonal antibody to endotoxin in the treatment of Gram-negative sepsis. JAMA 1991; 266:1097-1102
5. Fisher CJ, Dhainaut JFA, Opal SM, et al: Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. JAMA 1994; 271: 1836-1843
6. Abraham E, Wunderink R, Silverman H, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter trial. JAMA 1995; 273:934-941
7. Sprung CL: Changing attitudes and practices in forgoing life-sustaining treatments. JAMA 1990; 263:2211-2215
8. Grenvik A, Powner DJ, Snyder JV, et al: Cessation of therapy in terminal illness and brain death. Crit Care Med 1978; 6:284-291
9. Koch KA, Rodeffer HD, Wears RL: Changing patterns of terminal care management in an intensive care unit. Crit Care Med 1994; 22:233-243
10. Vincent JL, Parquier JN, Preiser JP, et al: Terminal events in the intensive care unit: Review of 258 fatal cases in one year. Crit Care Med 1989; 17: 530-533
11. Smedira NG, Evans BH, Grais LS, et al: Withholding and withdrawal of support from the critically ill. N Engl J Med 1990; 322:309-315
12. Murray LS, Teasdale GM, Murray GD, et al: Does prediction of outcome alter patient management? Lancet 1993; 341:1487-1491
13. Daffurn K, Kerridge R, Hillman KM: Active management of the dying patient. Med J Australia 1992; 157: 701-704
14. Lee DK, Swinburne AJ, Fedullo AJ, et al: Withdrawing care. Experience in a medical intensive care unit. JAMA 1994; 271:1358-1361
15. Faber-Langendoen K, Bartels DM: Process of forgoing life-sustaining treatment in a university hospital: An empirical study. Crit Care Med 1992; 20: 570-577
16. Zimmerman JE, Knaus WA, Sharpe SM, et al: The use and implications of do not resuscitate orders in intensive care units. JAMA 1986; 255:351-356
17. Wilson WC, Smedira NG, Fink C, et al: Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA 1992; 267:949-953
18. The Society of Critical Care Medicine Ethics Committee: Attitudes of critical care professionals concerning foregoing life-sustaining treatments. Crit Care Med 1992; 20:320-326
19. President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Deciding to Forego Life-Sustaining Treatment: Ethical, Medical and Legal Issues in treatment decisions. Washington, DC, Government Printing Office, 1983