Pharmacokinetics of oral fluconazole when used for prophylaxis in bone marrow transplant recipients

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 5, 1997, Pages 914-917

  El Yazigi, Adnan ^a   Ellis, Michael ^a   Ernst, Peter ^a   Spence, David ^a   Hussain, Rajaa ^a   Baillie, Fiona J ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; BONE MARROW TRANSPLANTATION; CHEMOPROPHYLAXIS; CLINICAL ARTICLE; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; FEMALE; HEMORRHAGIC CYSTITIS; HUMAN; LEUKEMIA; MALE; MYCOSIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0030989037     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.5.914     Document Type: Article

References (25)

1. Brammer, K. W., and P. E. Coates. 1994. Pharmacokinetics of fluconazole in pediatric patients. Eur. J. Clin. Microbiol. Infect. Dis. 13:325-329.
2. DeMuria, D., A. Forrest, J. Rich, J. M. Scavone, L. G. Cohen, and P. H. Kazanjian. 1993. Pharmacokinetics and bioavailability of fluconazole in patients with AIDS. Antimicrob. Agents Chemother. 37:2187-2192.
3. Efros, M. D., T. Ahmed, N. Coombe, and M. S. Choudhury. 1994. Urologic complications of high-dose chemotherapy and bone marrow transplantation. Urology 43:355-360.
4. Ellis, M. E., H. Clink, P. Ernst, M. A. Halim, A. Padmos, D. Spence, M. Kalin, S. M. Hussain Qadri, J. Burnie, and W. Greer. 1994. Controlled study of fluconazole in the prevention of fungal infections among neutropenic patients with haematological malignancies and bone marrow transplant recipients. Eur. J. Clin. Microbiol. Infect. Dis. 13:3-11.
5. Fischman, A. J., N. M. Alpert, E. Livni, S. Ray, I. Sinclair, and R. J. Callahan. 1993. Pharmacokinetics of 18F-labeled fluconazole in healthy human subjects by positron emission tomography. Antimicrob. Agents Chemother. 37:1270-1277.
6. Gibaldi, M., and D. Perrier. 1975. Pharmacokinetics. Marcel Dekker, New York.
7. Goodman, J. L., P. L. Winston, R. A. Greenfield, P. H. Chandrasekar, B. Fox, H. Kaiser, R. K. Shadduck, T. C. Shea, P. Stiff, D. J. Friedman, W. G. Powderly, J. L. Silber, H. Horowitz, A. Lichtin, S. N. Wolff, K. F. Mangan, S. M. Silver, D. Weisdorf, W. G. Ho, G. Gilbert, and D. Buell. 1992. A controlled study of fluconazole to prevent fungal infection in patients undergoing bone marrow transplantation. N. Engl. J. Med. 326:845-851.
8. Inagaki, K., J. Takagi, E. Lor, M. P. Okamoto, and M. A. Gill. 1992. Determination of fluconazole in human serum by solid-phase extraction and reversed-phase high-performance liquid chromatography. Ther. Drug Monit. 14:306-311.
9. Krzeska, I., R. A. Yeates, and G. Pfaff. 1993. Single dose intravenous pharmacokinetics of fluconazole in infants. Drugs Exp. Clin. Res. 19:267-271.
10. Lee, J. W., N. L. Seibel, M. Amantea, P. Whitcomb, P. A. Pizzo, and T. J. Walsh. 1992. Safety and pharmacokinetics of fluconazole in children with neoplastic diseases. J. Pediatr. 120:987-993.
11. McLachlan, A. J., and S. E. Tett. 1996. Pharmacokinetics of fluconazole in people with HIV infection: a population analysis. Br. J. Clin. Pharmacol. 41: 291-298.
12. Milliken, S., R. Powles, A. Jones, and G. Helenglass. 1989. Pharmacokinetics of oral fluconazole in autologous bone marrow transplantation recipients given TBI and high-dose melphalan. Transplant. Proc. 21:3067.
13. Ripa, S., L. Ferrante, and M. Prenna. 1993. Pharmacokinetics of fluconazole in normal volunteers. Chemotherapy 39:6-12.
14. Ruhnke, M., R. A. Yeates, G. Pfaff, E. Sarnow, A. Hartmann, and M. Trautmann. 1995. Single-dose pharmacokinetics of fluconazole in patients with liver cirrhosis. J. Antimicrob. Chemother. 35:641-647.
15. Sculier, J. P., T. S. D. Weer, and J. Klastersy. 1981. Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy. Eur. J. Cancer Clin. Oncol. 20:55-60.
16. Seay, R. E., T. A. Larson, J. P. Toscano, B. C. Bostrom, M. C. O'Leary, and D. L. Uden. 1995. Pharmacokinetics of fluconazole in immune-compromised children with leukemia or other hematologic diseases. Pharmacothcrapy 15:52-58.
17. Shiba K., A. Saito, and T. Miyahara. 1990. Safety and pharmacokinetics of single oral and intravenous doses of fluconazole in healthy subjects. Clin. Ther. 12:206-215.
18. Tett, S., S. Moore, and J. Ray. 1995. Pharmacokinetics and bioavailability of fluconazole in two groups of males with human immunodeficiency virus (HIV) infection compared with those in a group of males without HIV infection. Antimicrob. Agents Chemother. 39:1835-1841.
19. Thorpe, J. E., N. Baker, and M. Bromet-Petit. 1990. Effect of oral antacid administration on the pharmacokinetics of oral fluconazole. Antimicrob. Agents Chemother. 34:2032-2033.
20. Toon, S., C. E. Ross, R. Gokal, and M. Rowland. 1990. An assessment of the effects of impaired renal function and haemodialysis on the pharmacokinetics of fluconazole. Br. J. Clin. Pharmacol. 29:221-226.
21. Wingard, J. R., W. G. Merz, M. G. Rinaldi, T. R. Johnson, J. E. Karp, and R. Saral. 1991. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N. Engl. J. Med. 325:1274-1277.
22. Winston, D. J., P. H. Chandrasekar, H. M. Lazarus, J. L. Goodman, J. S. Silber, H. Horowitz, R. K. Shadduck, C. S. Rosenfeld, W. G. Ho, M. Z. Islam, and D. N. Buell. 1993. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann. Intern. Med. 118:495-503.
23. Yeates, R. A., M. Ruhnke, G. Pfaff, A. Hartmann, M. Trautmann, and E. Sarnow. 1994. The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients. Br. J. Clin. Pharmacol. 38(1):77-79.
24. Zimmermann, T., R. A. Yeates, H. Laufen, and A. Wildfeuer. 1994. Influence of concomitant food intake on the oral absorption of two triazole antifungal agents itraconazole and fluconazole. Eur. J. Clin. Pharmacol. 46:147-150.
25. Zimmermann, T., R. A. Yeates, K. D. Riedel, P. Lach, and H. Laufen. 1994. The influence of gastric pH on the pharmacokinetics of fluconazole: the effect of omeprazole. Int. J. Clin. Pharmacol. Ther. 32:491-494.