Cardiovascular effects of a trandolapril/verapamil combination in patients with mild to moderate essential hypertension

American Journal of Cardiology

Volumn 79, Issue 6, 1997, Pages 826-828

  Aepfelbacher, Franz C ^a   Messerli, Franz H ^a   Nunez, Eduardo ^a   Michalewicz, Leszek ^a  

^a Ochsner C   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANDOLAPRIL; VERAPAMIL;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; CARDIOVASCULAR EFFECT; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; DOSE RESPONSE; DRUG FORMULATION; DRUG MECHANISM; DRUG MIXTURE; ESSENTIAL HYPERTENSION; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART OUTPUT; HEART RATE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

AGED; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR SYSTEM; DELAYED-ACTION PREPARATIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPERTENSION; INDOLES; MALE; MIDDLE AGED; TIME FACTORS; VERAPAMIL;

EID: 0030988987     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(96)00883-1     Document Type: Article

References (20)

1. Materson BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kochar MS, Hamburger RJ, Fye C, Lakshman R, Gottdiener J, Ramirez EA, Henderson WG. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. N Engl J Med. 328:1993;914-921.
2. Messerli FH. Combination therapy in hypertension. J Hum Hypertens. 6:((suppl 2)):1992;S19-S21.
3. Menard J, Bellet M. Calcium antagonists-ACE inhibitors combination therapy: objectives and methodology of clinical development. J Cardiovasc Pharmacol. 21:((suppl 2)):1993;S49-S54.
4. Messerli FH, De Carvalho JGR, Christie B, Frohlich ED. Systemic and regional hemodynamics in low, normal and high cardiac output borderline hypertension. Circulation. 58:1978;441-448.
5. Dunn FG, Chandraratna P, De Carvalho JGR, Basta LL, Frohlich ED. Pathophysiologic assessment of hypertensive heart disease with echocardiography. Am J Cardiol. 39:1977;789-795.
6. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 58:1978;1072-1083.
7. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 57:1986;450-458.
8. de Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, Alderman MH, Laragh JH. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol. 23:1994;1444-1451.
9. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 76:1937;7-11.
10. Wallerson DC, Ganau A, Roman MJ, Devereux RB. Measurement of cardiac output by M-mode and two-dimensional echocardiography: application to patients with hypertension. Eur Heart J. 11:((suppl I)):1990;67-78.
11. Schmieder RE, Messerli FH, Garavaglia GE, Nunez BD. Cardiovascular effects of verapamil in patients with essential hypertension. Circulation. 75:1987;1030-1036.
12. Messerli FH, Oren S, Grossman E. Effects of calcium channel blockers on systemic hemodynamics in hypertension. Am J Med. 84:((suppl. 3B)):1988;8-12.
13. Guller B, Hall J, Reeves RL. Cardiac effects of trandolapril in hypertension. Am Heart J. 125:((5 pt 2)):1993;1536-1541.
14. de Champlain J, Yacine A, Le Blanc R, Bouvier M, Lebeau R, Nadeau R. Effects of trandolapril on the sympathetic tone and reactivity in systemic hypertension. Am J Cardiol. 73:((suppl)):1994;18C-25C.
15. Morgan TO, Anderson A, Jones E. Comparison and interaction of low dose felodipine and enalapril in the treatment of essential hypertension in elderly subjects. Am J Hypertens. 5:1992;238-243.
16. Guazzi MD, De Cesare N, Galli C, Salviani A, Tramantana C, Tamborini G, Bartorelli A. Calcium-channel blockade with nifedipine and angiotensin converting-enzyme inhibition with captopril in the therapy of patients with severe primary hypertension. Circulation. 70:1984;279-284.
17. Di Somma S, Carotenuto A, de Divitiis M, Paulucci A, Galderisi M, Cuocolo A, de Divitiis O. Favourable interaction of calcium antagonist plus ACE inhibitor on cardiac hemodynamics in treating hypertension: rest and effort evaluation. J Hum Hypertens. 9:1995;163-168.
18. Messerli FH. Left ventricular hypertrophy: impact of calcium channel blocker therapy. Am J Med. 90:((5A)):1991;27S-31S.
19. Gilbert BW. ACE inhibitors and regression of left ventricular hypertrophy. Clin Cardiol. 15:1992;711-714.
20. Ketelhut R, Franz IW, Behr U, Toennesmann U, Messerli FH. Preserved ventricular pump function after a marked reduction of left ventricular mass. J Am Coll Cardiol. 20:1992;864-868.