A convenient synthesis of N4,O3′,O 5′-triacetyl-2′-ketocytidine

Nucleosides and Nucleotides

Volumn 16, Issue 4, 1997, Pages 469-474

  Kjell, Douglas P ^a   Slattery, Brian J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DERIVATIVE; N4, O3', O5' TRIACETYL 2' KETOCYTIDINE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG OXIDATION; DRUG PURIFICATION; DRUG SYNTHESIS;

EID: 0030988280     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319708001363     Document Type: Article

References (15)

1. a. Bergstrom, D.E.; Mott, A.W.; De Clercq, E.; Baizarini, J.; Swartling, D.J. J. Med. Chem. 1992,35, 3369
2. b. Sabol, J.S.; McCarthy, J.R. Tetrahedron Lett. 1992, 33,3101
3. Antonakis, K. Adv. Carbohydr. Chem. Biochem. 1984, 42. 227
4. a. Robins, M.J.; Samano, V.; Zhang, W.; Baizarini, J.; De Clercq, E.; Borchardt, R.T.; Lee, Y.; Yuan, C-S. J. Med. Chem., 1992, 35,2283
5. b. Hansske.F.; Madej, D.; Robins, M.J. Tetrahedron, 1984, 40,125
6. Cook, A.F.; Moffatt, J.G. J. Am. Chem. Soc., 1967, 89,2697
7. Brodbeck, U.; Moffatt, J.G. J. Org. Chem., 1970,35, 3552
8. Hansske, F.; Robins, M.J. Tetrahedron Lett., 1983,24, 1589
9. a. Kondo, K.; Inoue, I. J. Org. Chem. 1977, 42,2809
10. b. Kondo, K.; Inoue, I. J. Org. Chem. 1980, 45, 1577
11. Marcuccio, S.M.; Elmes, B.C.; Holan, G.; Middleton, E.J. Nucleosides & Nucleotides 1992, 11, 1695
12. Chwang, T.L.; Fridland, A.; Avery, T.L. J. Med. Chem. 1983,26,280
13. Samano, V.; Robins, M.J. J. Org. Chem. 1990.55, 5186
14. Ireland, R.E.; Liu, L. J. Org. Chem. 1993,58,2899
15. We assume the product formed the hydrate under the conditions of the elemental analysis. All spectra show no evidence of water.