Preferential induction of chromosome 1 multibranched figures and whole-arm deletions in a human pro-B cell line treated with 5-azacytidine or 5-azadeoxycytidine

Cytogenetics and Cell Genetics

Volumn 76, Issue 3-4, 1997, Pages 196-201

  Hernandez, R ^a   Frady, A ^a   Zhang, X Y ^a   Varela, M ^a   Ehrlich, M ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DNA;

ARTICLE; B LYMPHOCYTE; CHROMOSOME 1; CHROMOSOME 16; CHROMOSOME 9; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA METHYLATION; GENOTOXICITY; HUMAN; HUMAN CELL; ISOCHROMOSOME; KARYOTYPE; LYMPHOID CELL LINE; PRIORITY JOURNAL; PROLYMPHOCYTE;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; B-LYMPHOCYTES; CELL LINE; CENTROMERE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 1; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELLS; HUMANS; TIME FACTORS;

EID: 0030988255     PISSN: 03010171     EISSN: 1424859X     Source Type: Journal    
DOI: 10.1159/000134548     Document Type: Article

References (27)

1. Altiok E, Klein G, Zech L, Uno M, Henriksson BE, Bat-tat S, Ono Y, Ernberg 1: Epstein-Barr virus-trans-romied pro-B cclls arc prone to illegitimate recombination between the switch region of the n chain gene and other chromosomes. Proc natl Acad Sci. USA 86:6333-6337 (1989).
2. Brito-Babapulle V, Atkin NB: Break points in chromosome #1: abnormalities of 218 human neoplasms, Cancer Genet Cytogcnel 69:91 -99 (1981).
3. Fryns JP, Azou M, Jacken J, Eggermont E, Pedersen JC, Van den Bcrghe H: Centromeric instability of chromosomes 1, 9, and 16 associated with combined immunodeficiency. Hum Genet 57:108-110 (1981).
4. Gagos S, Iatridou-Kyrkou K, Liosi A, Karakitsos P, Papageorgaki P, Kyroudi A, Pathak S: Clonal evolution of an immunoblastic type non-Hodgkin's lymphoma with der(6)t(1:6)(ql l:pl 1) as its primary cytogcnetic abnormality, Cancer Genet Cyto-genet 79:59-63 (1995).
5. Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC, Gchrkc CW, Ehrlich M: The 5-methyl-cytosine content of DNA from human tumors, Nucl Acids Res 11:6883-6894 (1983).
6. Haaf T: The effects of 5-azacytidinc and 5-azadeoxycy-tidine on chromosome structure and function: implications for methylation-associated cellular processes, Pharmacol fher 65:19-46 (1995).
7. Heim S, Mitelman F: Tumors of the breast, in Cancer Cvtogenetics, pp 369-388 (Wilev-Liss, New York 1995).
8. Herman JG, Jen J, Mcrlo A, Bavlin SB: Hypermethyla-tion-associated inactivation indicates a tumor suppressor role for pI5ink4bl, Cancer Res 56:722-727(1996).
9. Hori T-A: Induction of chromosome decondensation, sister chromatid exchanges and endoreduplica-tions by 5-azacytidine, an inhibitor of DNA meth-ylation, Mutat Res 121:47-52 (1983).
10. Jeanpierre M, Turleau C, Aurias A, Prieur M, Ledcist F, Fischer A, Viegas-Pequignot E: An embryonic-like inethylation pattern of classical satellite DNA is observed in ICF svndrome, Hum molec Genet 2:731-735(1993).
11. Katamine S, Otsu M, Tada K, Tsuchiya S, Sato T, Ishi-da N, Honjo T, Ono Y: Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements, Nature 309:369 (1984).
12. Kokalj-Vokac N, Almeida A, Gerbault-Seureau M, Malfoy B, Dutrillaux B: Two-color FISH characterization ofi(lq)and der(1; 16) in human breast cancer cclls, Genes 7:8-14 (1993a).
13. Kokalj-Vokac N, Almeida A, Viegas-Pequignot E, Jeanpierre M, Malfoy B: Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive hcterochroma-tin, Cytogenet Cell Genet 63:11-15 (1993b).
14. Lai JL, Zandecki M, Mary JY, Bemardi F, Izydorczyk V, Flactif M, Morel P, Jouet JP, Bauters F, Facon T: Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis, Blood 85:2490-2497 (1995).
15. Lewis JD, Meehan RR, Henzcl WJ, Maurer-Fogy I, Jeppeson P, Klein F, Bird A: Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA, Cell 69:905-914(1992).
16. Miniou P, Jeanpierre M, Blanquet V, Sibella V, Bon-neau D, Herbelin C, Fischer A, Niveleau A, Viegas-Pequignot ET: Abnormal mcthylation pattern in constitutive and facultative (X inactive chromosome) heterochromatin of ICF patients, Hum mo-lec Genet 3:2093-2102(1994).
17. Morad M, Jonasson J, Lindsten J: Distribution of mitomycin C induced breaks on human chromosomes, Hereditas 74:273-282 (1973).
18. Murakami T, Li X, Gong J, Bhutto U, Traganos F: Induction of apoptosis by 5-azacytidine: drug con-centration-dependent differences in cell cycle specificity, Cancer Res 55:3093-3098 (1995).
19. Nan X, Tante P, Li E, Bird A: DNA mcthylation specifics chromosomal localization of MeCP2, Mol cell Biol 16:414-421 (1996).
20. Santi DV, Garrett CE, Barr PJ: On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs, Cell 33:9-10 (1983).
21. Sawyer JR, Swanson CM, Koller MA, North PE, Ross SW: Centromeric instability of chromosome I resulting in multibranched chromosomes, telomeric fusions, and "jumping translocations" of Iq in a human immunodeficiency virus-related non-Hodgkin's lymphoma, Cancer 76:1238-1244 (1995).
22. Schmid M, Grunert D, Haaf T, Engel W: A direct demonstration of somatically paired heterochromatin of human chromosomes, Cytogenet Cell Genet 36:554-561 (1983).
23. Schmid M, Haaf T, Grunert D: 5-Azacytidine-induced undercondcnsalions in human chromosomes, Hum Genet 67:257-263 (1984).
24. Schuffenhaucr S, Bartsch O, Stumm M, Buchholz T, Petropoulou T, Kraft S, Belohradsky B, Meitinger T, Wegncr R: DNA, FISH and complementation studies in ICF syndrome: DNA hypomethylation of repetitive and single copy loci and evidence for a tram acting factor, Hum Genet 96:562-571 (1995).
25. Smeets DFCM, Moog U, Weemaes CMR, Vacs-Peeters G, Merkx GFM, Niehof JP, Hamers G: ICF syndrome: a new case and review of the literature, Hum Genet 94:240-246 (1994).
26. Stopper H, Pechan R, SchifTman D: 5-Azacvtidine induccs micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis, Mutat Res 283:21-28(1992).
27. Turleau C, Cabanis M-O, Giraull D, Ledeist F, Mettey R, Puissant H, Marguerite P, de Grouchy J: Multibranched chromosomes in the ICF syndrome: immunodeficiency, ceniromeric instability, and facial anomalies, Am J med Genet 32:420-424 (1989).