Sensitivity of combined DNA/immunophenotype flow cytometry for the detection of low levels of aneuploid lymphoblastic leukemia cells in bone marrow

Communications in Clinical Cytometry

Volumn 30, Issue 1, 1997, Pages 47-53

  Nowak, Ralf ^a   Oelschlaegel, Uta ^a   Schuler, Ulrich ^a   Zengler, Heidrun ^a   Hofmann, Rita ^a   Ehninger, Gerhard ^a   Andreeff, Michael ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

acute lymphoblastic leukemia; aneuploidy; flow cytometry

Indexed keywords

CD19 ANTIGEN; CD34 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANEUPLOIDY; ARTICLE; BONE MARROW; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; PRIORITY JOURNAL;

ANEUPLOIDY; ANTIGENS, CD3; ANTIGENS, NEOPLASM; BONE MARROW; BONE MARROW CELLS; DNA; DNA, NEOPLASM; FLOW CYTOMETRY; G0 PHASE; G1 PHASE; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, ACUTE; S PHASE; SENSITIVITY AND SPECIFICITY;

EID: 0030987944     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(19970215)30:1<47::AID-CYTO7>3.0.CO;2-C     Document Type: Article

References (31)

1. Andreeff M: Flow cytometry in leukemia. In: Mclamed MR, Lidmo T, Mendelson ML b (eds) J. Wiley & Sons, New York. 1990, pp 697-724
2. Bartram CR: Detection of minimal residual leukemia by the polymerase chain reaction: potential implications for therapy. Clin-Chim-Acta 217:75-83, 1993.
3. Beishuizen A, Hahlen K, Hagemeijer A, Verhoeven MA, Hooijkaas H, Adriaansen HJ, Wolvers-Tettero IL, van-Wering ER, van Dongen JJ: Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia 5:657-67, 1991.
4. Beishuizen A, Verhoeven MA, van Wering ER, Hahlen K, Hooijkaas H, van-Dongen J: Analysis of Ig and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: Implications for the detection of minimal residual disease by polymerase chain reaction analysis. Blood 83:2238-2247, 1994.
5. Benson NA, Braylan RC: Evaluation of sensitivity in DNA aneuploidy detection using a mathematical model. Cytometry 15:53-58, 1994.
6. Brons PT, Pennings A, Haanen C, Wessels HMC, Boezman BM: Simultaneous measurement of DNA content and cell surface immunofluorescence of human bone marrow cells using a single laser flow cytometer. Cytometry 11:837-844, 1990.
7. Campana D: Monitoring minimal residual disease in acute leukemia: Expectations, possibilities, and initial clinical results. Int J Clin Lab Res 24:132-138, 1994.
8. Campana D: Applications of cytometry to study acute leukemia: In vitro determination of drug sensitivity and detection of minimal residual disease. Cytometry 18:68-74, 1994.
9. Coustan Smith E, Behm FG, Hurwitz CA, Rivera GK, Campana D: N-CAM (CD56) expression by CD34+ malignant myeloblasts has implications for minimal residual disease detection in acute myeloid leukemia. Leukemia 7:853-858, 1993.
10. Downing JR, Head DR, Raimondi SC, Carroll AJ, Curcio-Brint AM, Motroni TA, Hulshof MG, Pullen DJ, Domer PH: The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia. Blood 83:330-335, 1994.
11. Drach J, Drach D, Glassl H, Gattringer C, Huber-H: Flow cytometric determination of atypical antigen expression in acute leukemia for the study of minimal residual disease. Cytometry 13:893-901, 1992.
12. Griesinger F, Elfers H, Ludwig WD, Falk M, Rieder H, Harbott J, Lampert F, Heinze B, Hoelzer D, Thiel E, Riehm H, Woermann B, Fonatsch C, Hiddemann W: Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11). Leukemia 8:542-548, 1994.
13. Hollander Z, Loken MR: Simultaneous analysis of DNA content and surface antigen in human hone marrow. Cytometry 9:485-490, 1988.
14. Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML: The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 77:687-693, 1991
15. Hurwitz C, Gore SD, Stone KD, Civin CI: Flow cytometric detection of rare normal human hone marrow cells with immunophenotypes characteristic of acute lymphoblastic leukemia cells. Leukemia 6:233-239, 1992.
16. Imamura N, Kuramoto A: Detection of minimal residual disease in acute lymphoblastic leukemia by flow cytometry with monoclonal antibodies. Am J Hematol 38:332-334, 1991.
17. Jensen IM, Ellegaard J, Hokland P: Differences in relative DNA content between human peripheral blood and bone marrow subpopulations: Consequences for DNA-index calculations. Cytometry 14:936-942, 1993
18. Macedo A, Orfao A, Vidriales MB, Lopez Berges MC, Valverde B, Gonzalez M, Caballero MD, Ramos F, Martinez M, Fernandez Calvo J: Characterization of aberrant phenotypes in acute myeloblastic leukemia. Ann Hematol 70:189-194, 1995.
19. Miyamura K, Takeo T, Kataoka T, Tahara T, Tanimoto M, Saito H: Detection of minimal residual disease in Philadelphia chromosome positive acute lymphoblastic leukemia: Rationale for bone marrow transplantation from the polymerase chain reaction point of view. Leuk Lymphoma 11:181-189, 1993.
20. Nakano M, Kuriyama Y, Kawanishi Y, Toyama K: Clinical implication and prognostic significance of small lymphoma cells in the peripheral blood and hone marrow of B-cell non-Hodgkin's lymphomas. Leuk Lymphoma. 11:119-127, 1993.
21. Nowak R, Oelschlaegel U, Hofmann R, Zengler H, Huhn-R: Detection of aneuploid cells in acute lymphoblastic leukemia with flow cytometry before and after therapy. Leuk Res 18:897-901, 1994.
22. Orfao A, Ciudad J, Lopez-Berges MC, Lopez A, Vidriales B, Caballero MD, Valverde B, Gonzalez M, San Miguel JF: Acute lymphoblastic leukemia (ALL): Detection of minimal residual disease (MRD) at flow cytometry. Leuk Lymphoma 13 Suppl 1:87-90, 1994.
23. Reading CL, Estey EH, Huh YO, Claxton DF, Sanchez G, Terstappen LWMM, O'Brien MC, Baron S, Deisseroth AB: Expression of unusual immunophenotype combinations in acute myelogenous leukemia. Blood 81:3083-3090, 1993.
24. Richardson DS, Johnson SA, Hopkins JA, Howe D, Phillips MJ: Absence of minimal residual disease detectable by FACS, Southern blot, or PCR in patients with chronic lymphocytic leukaemia treated with fludarabine. Acta Oncol 33:627-630, 1994
25. Robertson LE, Huh YO, Butler JJ, Pugh WC, Hirsch Ginsberg C, Stass S, Kantarjian H, Keating MJ: Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: Clinical, pathologic, immunophenotypic, and molecular analysis. Blood 80:29-36, 1992.
26. Sambrook J, Fritsch EF, Maniatis T: Molecular cloning: A laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, New York. 1989.
27. Sievers EL, Loken MR: Detection of minimal residual disease in acute myelogenous leukemia. J Pediatr Hematol Oncol 17:123-133, 1995.
28. Thaler J, Grünewald K, Gattringer C, Ho AD, Weyrer K, Dietze O, Stauder R, Fluckinger T, Lang A, Huber H: Long term follow-up of patients with hairy cell leukemia treated with pentostatin: Lymphocyte subpopulations and residual bone marrow infiltration. Br J Hematol 84:75-82, 1993.
29. Uckun FM, Kersey JH, Haake R, Weisdorf D, Nesbit ME, Ramsay NK: Pretransplantation burden of leukemic progenitor cells as a predictor of relapse after bone marrow transplantation for acute lymphoblastic leukemia. N Engl J Med 329:1296-1301, 1993.
30. Uckun FM, Kersey JH, Haake R, Weisdorf D, Ramsay NK: Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging. Blood 79:1094-1104, 1992.
31. Venditti A, Del Poeta G, Stasi R, De Fabriitis P, Coppetelli U, Bruno A, Simone MD, Papa G: Triple immunofluorescence evaluation of CD15, CD34, and class II expression by flow cytometry in normal and leukemic bone marrows. Haematologica 78:359-63, 1993.