Role of perforin, granzymes and the proliferative state of the target cells in apoptosis and necrosis mediated by bispecific-antibody-activated cytotoxic T cells

Cancer Immunology Immunotherapy

Volumn 44, Issue 2, 1997, Pages 70-76

  Renner, Christoph ^a   Held, Gerhard ^a   Ohnesorge, Sascha ^a   Bauer, Stefan ^a   Gerlach, Klaus ^a   Pfitzenmeier, Jan Peter ^a   Pfreundschuh, Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

bispecific antibodies; granzymes; Hodgkin's lymphoma; perforin; T lymphocytes

Indexed keywords

BISPECIFIC ANTIBODY; CD28 ANTIGEN; CD3 ANTIGEN; GRANZYME A; GRANZYME B; PERFORIN; TUMOR ANTIGEN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; NECROSIS; PRIORITY JOURNAL; TUMOR CELL DESTRUCTION;

ANTIBODIES, BISPECIFIC; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD; ANTIGENS, CD95; APOPTOSIS; BLOTTING, NORTHERN; CYTOTOXICITY, IMMUNOLOGIC; DNA FRAGMENTATION; GRANZYMES; HODGKIN DISEASE; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; NECROSIS; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0030987820     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050357     Document Type: Article

References (33)

1. Berke G (1995) The CTL's kiss of death. Cell 81: 9
2. 51Cr release assays. J Immunol 150: 2305
3. Beun GDM, Velde JH v de, Fleuren GJ (1994) T-cell based cancer immunotherapy: direct or redirected tumor-cell recognition? Immunol Today 15: 11
4. Chomczynski P, Sacchi N (1987) Single-step method for RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 612: 156
5. 1 lymphoma: increased efficacy with multiple injections and CD28-induced costimulation. Blood 87: 4390
6. Gerdes J, Schwab U, Lemke H, Stein H (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13
7. Gold R, Schmied M, Rothe G, Zischler H, Breitschopf H, Wekerle H, Lassmann H (1993) Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. J Histochem Cytochem 41: 1023
8. Griffiths GM (1995) The cell biology of CTL killing. Curr Opin Immunol 7: 343
9. Griffiths GM, Namikawa R, Mueller Ch, Liu CC, Young JDE, Billingham M, Weissman I (1991) Granzyme A and perform as markers for rejection in cardiac transplantation. Eur J Immunol 21: 687
10. Hayes MP, Berrebi GA, Henkart PA (1989) Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A. J Exp Med 170: 933
11. Hoon DSB, Hayashi Y, Morisaki T, Foshag LJ, Morton DL (1993) Interleukin-4 plus tumor necrosis factor augments the antigenicity of melanoma cells. Cancer Immunol Immunother 37: 378
12. Kägi D, Ledermann B, Bürki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369: 31
13. Lèger-Ravet MB, Devernge O, Peuchmaur M, Solal-Celigny P, Brousse N, Gaulard P, Galanaud P, Emilie D (1994) In-situ detection of activated cytotoxic cells in follicular lymphomas. Am J Pathol 144: 492
14. Lèger-Ravet MB, Mathiot C, Portier A, Brandely M, Galanaud P, Fridman WH, Emilie D (1994) Increased expression of perform and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2. Cancer Immunol Immunother 39: 53
15. Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H, Podack ER (1989) Structure and function of human perform. Nature 335: 448
16. 2+. Immunology 39: 109
17. Migliorati G, Nicoletti IM, Pagliacci C, D'Adamio L, Riccardi C (1993) Interleukin-2 induces apoptosis in mouse thymocytes. Cell Immunol 146: 52
18. Milstein C, Cuello AC (1983) Hybrid hybridomas and their use in immunohistochemistry. Nature 305: 537
19. Nakajima H, Henkart PA (1994) Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown. J Immunol 152: 1057
20. Nakajima F, Khanna A, Xu G, Lagman M, Haschemeyer R, Mouradia J, Wang JC, Stenzel KH, Rubin AL, Suthanthiran M (1994) Immunotherupy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression. Proc Natl Acad Sci USA 91: 7889
21. Nakamura Y, Wakimoto H, Abe J, Kanegae Y, Saito I, Aoyagi M, Kikiyoshi H, Hamada H (1994) Adoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin 2. Cancer Res 54: 5757
22. Nishioka WK, Welsh RM (1994) Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target. J Exp Med 179: 769
23. Qian JH, Ttius JA, Andew SM, Mezzanzanica D, Garrido MA, Wunderlich JR, Segal DM (1991) Human peripheral blood lymphocytes targeted with bispecific antibodies release cytokines that are essential for inhibiting tumor growth. J Immunol 146: 3250
24. Renner C, Pfreundschuh M (1995) Tumor therapy by immune recruitment with bispecific antibodies. Immunol Rev 145: 179
25. Renner C, Jung W, Sahin U, Denfeld R, Pohl C, Trümper L, Hartmann F, Diehl V, Lier R van, Pfreundschuh M (1994) Cure of xenografted human tumors by bispecific monoclonal antibodies and human T-cells. Science 264: 833
26. Renner C, Jung W, Sahin U, Pfreundschuh M (1995) The role of lymphocyte subsets and adhesion molecules in T-cell dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies. Eur J Immunol 25: 2027
27. Renner C, Bauer St, Sahin U, Jung W, Lier R van, Jacobs G, Held G, Pfreundschuh M (1996) Cure of disseminated xenogratted human Hodgkin's tumor by bispecific monoclonal antibodies and human T cells: the role of human T-cell subsets in a preclinical model. Blood 87: 2930
28. Schmid I, Uittenbogaart CH, Keld B, Giorgi JV (1994) A rapid method for measuring apoptosis and dual color immunofluorescence by single laser flow cytometry. J Immunol Methods 170: 145
29. Shi L, Kam CM, Powers JC, Aebesold R, Greenberg AH (1992) Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 176: 1521
30. Shinkai Y, Takio K, Okumura K (1988) Homology of perform to the ninth component of complement (C9). Nature 334: 525
31. Tschopp J, Nabholz M (1990) Perforin-mediated target cell lysis by cytolytic T lymphocytes. Annu Rev Immunol 8: 279
32. Walsh CM, Maltoubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MTF, Young JDE, Ahmed R, Clark WR (1994) Immune function in mice lacking the perform gene. Proc Natl Acad Sci USA 91: 10854
33. Young JDE (1989) Killing of target cells by lymphocytes: a mechanistic view. Physiol Rev 69: 250