Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid

Molecular Endocrinology

Volumn 11, Issue 7, 1997, Pages 962-972

  Dao Phan, Hai Pascal ^a   Formstecher, Pierre ^a   Lefebvre, Philippe ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DNA BINDING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

GALLUS GALLUS;

EID: 0030987768     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.7.9937     Document Type: Article

References (47)

1. Hutchison KA, Stancato LF, Owens-Grillo JK, Johnson JL, Krishna P, Toft DO, Pratt WB 1995 The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90. J Biol Chem 270:18841-18847
2. Owens-Grillo JK, Hoffmann K, Hutchison KA, Yem AW, Deibel MR, Handschumacher RE, Pratt WB 1995 The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor. J Biol Chem 270:20479-20484
3. Czar MJ, Owens-Grillo JK, Dittmar KD, Hutchison KA, Zacharek AM, Leach KL, Deibel MR, Pratt WB 1994 Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. J Biol Chem 269:11155-11161
4. Scherrer LC, Picard D, Massa E, Harmon JM, Simons SS, Yamamoto KR, Pratt WB 1993 Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein-90. Biochemistry 32:5381-5386
5. Kang KI, Devin J, Cadepond F, Jibard N, Guiochon-Mantel A, Baulieu EE, Catelli MG 1994 In vivo functional protein protein interaction-nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus. Proc Natl Acad Sci USA 91:340-344
6. Bresnick EH, Dalman FC, Sanchez ER, Pratt WB 1989 Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 264:4992-4997
7. Chandler VL, Maler BA, Yamamoto KR 1983 DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo. Cell 33:489-499
8. Payvar F, DeFranco DB, Firestone GL, Edgar BA, Wrange Ö, Okret S, Gustafsson JÅ, Yamamoto KR 1983 Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell 35:381-392
9. Bohen SP, Kralli A, Yamamoto KR 1995 Hold'em and fold'em: chaperones and signal transduction. Science 268:1303-1304
10. Pratt WB, Jolly DJ, Pratt DV, Hollenberg SM, Giguere V, Cadepond FM, Schweizer-Groyer G, Catelli MG, Evans RM, Baulieu EE 1988 A region in the steroid binding domain determines formation of the non-DNA-binding, 9S glucocorticoid receptor complex. J Biol Chem 263:267-273
11. Housley PR, Sanchez ER, Danielsen M, Ringold GM, Pratt WB 1990 Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain. J Biol Chem 265:12778-12781
12. Dalman FC, Scherrer LC, Taylor LP, Akil H, Pratt WB 1991 Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J Biol Chem 266:3482-3490
13. Cadepond F, Binart N, Chambraud B, Jibard N, Schweizer-Groyer G, Segard-Maurel I, Baulieu EE 1993 Interaction of glucocorticosteroid receptor and wild-type or mutated 90-kDa heat shock protein coexpressed in baculovirus-infected Sf9 cells. Proc Natl Acad Sci USA 90:10434-10438
14. Sullivan WP, Toft DO 1993 Mutational analysis of hsp90 binding to the progesterone receptor. J Biol Chem 268:20373-20379
15. Lefebvre P, Danze PM, Sablonnière B, Richard C, Formstecher P, Dautrevaux M 1988 Association of the glucocorticoid receptor binding subunit with the 90K nonsteroid-binding component is stabilized by both steroidal and nonsteroidal antiglucocorticoids in intact cells. Biochemistry 27:9186-9194
16. Binart N, Chambraud B, Dumas B, Rowlands DA, Bigogne C, Levin JM, Garnier J, Baulieu EE, Catelli MT 1989 The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (hsp90) reveals a DNA-like structure: potential site of interaction with steroid receptors. Biochem Biophys Res Commun 159:140-147
17. Heck S, Kullman M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, Cato ACB 1994 A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13: 4087-4095
18. Akner G, Wikström AC, Gustafson JA 1995 Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules. J Steroid Biochem Mol Biol 52:1-16
19. Pratt WB 1993 The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 268:21455-21458
20. Smith DF, Toft DO 1993 Minireview-steroid receptors and their associated proteins. Mol Endocrinol 7:4-11
21. Owens-Grillo JK, Czar MJ, Hutchison KA, Hoffman K, Perdew GH, Pratt WB 1996 A model of protein targeting mediated by immunophilins and other proteins that bind th hsp90 via tetratricopeptide repeat domains. J Biol Chem 271:13468-13475
22. Schowalter DB, Sullivan WP, Maihle NJ, Dobson ADW, Conneely OM, O'Malley BW, Toft DO 1991 Characterization of progesterone receptor binding to the 90- and 70- kDa heat shock proteins. J Biol Chem 266:21165-21173
23. Cadepond F, Jibard N, Binart N, Schweizer-Groyer G, Segard-Maurel I, Baulieu EE 1994 Selective deletions in the 90 kDa heat shock protein (hsp90) impede heterooligomeric complex formation with the glucocorticosteroid receptor (GR) or hormone binding by GR. J Steroid Biochem Mol Biol 48:361-367
24. Binart N, Lombes M, Baulieu EE 1995 Distinct functions of the 90 kDa heat-shock protein (hsp90) in oestrogen and mineralocorticosteroid receptor activity: effects of hsp90 deletion mutants. Biochem J 311:797-804
25. Gupta RS 1995 Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species. Mol Biol Evol 12:1063-1073
26. Picard D, Khursheed B, Garabedian MJ, Fortin MG, Lindquist S, Yamamoto KR 1990 Reduced levels of hsp90 compromise steroid receptor action in vivo. Nature 348:166-168
27. Whitelaw ML, Mcguire J, Picard D, Gustafsson JA, Poellinger L 1995 Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proc Natl Acad Sci USA 92:4437-4441
28. Dahlman-Wright K, Grandien K, Nilsson S, Gustafsson J, Carlstedt-Duke J 1993 Protein-protein interactions between the DNA-binding domains of nuclear receptors-influence on DNA-binding. J Steroid Biochem Mol Biol 45:239-250
29. Freedman LP, Luisi BF 1993 On the mechanism of DNA binding by nuclear hormone receptors-a structural and functional perspective. J Cell Biochem 51:140-150
30. Schulte TW, Blagosklonny MV, Ingui C, Neckers L 1995 Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-ras association. J Biol Chem 270:24585-24588
31. Whitesell, L, Cook, P 1996 Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. Mol Endocrinol 10:705-712
32. Smith DF, Whitesell L, Nair SC, Chen SY, Prapapanich V, Rimerman RA 1995 Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol 15:6804-6812
33. Arnold SF, Notides AC 1995 An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor. Proc Natl Acad Sci USA 92: 7475-7479
34. Tbarka N, Richard-Mereau C, Formstecher P, Dautrevaux M 1993 Biochemical and immunological evidence that an acidic domain of hsp-90 is involved in the stabilization of untransformed glucocorticoid receptor complexes. FEBS Lett 322:125-128
35. Sablonnière B, Lefebvre P, Formstecher P, Dautrevaux M 1987 Improved Stokes radius measurement of the glucocorticoid receptor using TSK G4000SW and TSK G3000SW high-performance size-exclusion columns. Analytical and preparative applications. J Chromatogr 403:183-196
36. Perdew GH, Whitelaw ML 1991 Evidence that the 90-kDa heat shock protein (hsp90) exists in cytosol in heteromeric complexes containing hsp70 and three other proteins of Mr 63,000, 56,000, and 50,000. J Biol Chem 266:6708-6713
37. Rousseau GG, Kirchkoff J, Formstecher P, Lustenberger P 1979 17-beta carboxamide steroids are a new class of glucocorticoid antagonists. Nature 279:158-160
38. Tahayato A, Lefebvre P, Formstecher P, Dautrevaux M 1993 A protein kinase C-dependent activity modulates retinoic acid-induced transcription. Mol Endocrinol 7:1642-1653
39. Lefebvre P, Berard DS, Cordingley MG, Hager GL 1991 Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines. Mol Cell Biol 11:2529-2537
40. Giguere V, Ong ES, Segui P, Evans RM 1987 Identification of a receptor for the morphogen retinoic acid. Nature 330:624-629
41. Kozak M 1991 Structural features in eukaryotic messenger RNAs that modulate the initiation of translation. J Biol Chem 266:19867-19870
42. Rusconi S, Yamamoto KR 1987 Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J 6:1309-1315
43. Gronemeyer H, Turcotte B, Quirin-Stricker C, Bocquel MT, Meyer ME, Krozowski Z, Jeltsch JM, Lerouge T, Garnier JM, Chambon P 1987 The chicken progesterone receptor: sequence, expression and functional analysis. EMBO J 6:3985-3994
44. Andersson S, Davis DL, Dahlback H, Jornvall, H Russell DW 1989 Cloning, structure, and expression of the mitochondrial cytochromeP-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem 264:8222-8229
45. Guiochon-Mantel A, Loosfelt H, Ragot T, Bailly A, Atger M, Misrahi M, Perricaudet M, Milgrom E 1988 Receptors bound to antiprogestin form abortive complexes with hormone responsive elements. Nature 336:695-698
46. Thompson JD, Higgins DG, Gibson TJ 1994 CLUSTAL W: improving the sensitivity of progressive multiple sequencealignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680
47. Hutchison KA, Dittmar KD, Pratt WB 1994 All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a "foldosome." J Biol Chem 269: 27894-27899