Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury

Journal of Pediatric Surgery

Volumn 32, Issue 6, 1997, Pages 905-910

  Savaş, Çaǧri ^a   Aras, Tülin ^a   Çakmak, Murat ^a   Bilgehan, Ayşe ^a   Ataoǧlu, Ömür ^a   Türközkan, Nurten ^a   Özgüner, Faruk ^a   Yücesan, Selçuk ^a   Dindar, Hüseyin ^a  

^a NONE

Author keywords

Blood flow; Pentoxifylline; Reperfusion injury; Small intestine

Indexed keywords

MALONALDEHYDE; MYELOPEROXIDASE; PENTOXIFYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; INTESTINE BLOOD FLOW; INTESTINE INJURY; INTESTINE MUCOSA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY;

EID: 0030987724     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(97)90648-5     Document Type: Article

References (24)

1. Megison SM, Horton JW, Chao H. et al: A new model for intestinal ischemia in the rat. J Surg Res 49:168-173, 1990
2. Schoenberg MH, Beger HG: Reperfusion injury after intestinal ischemia. Crit Care Med 21:1376-1386, 1993
3. Schoenberg MH, Muhl E, Sellin D, et al: Posthypotensive generation of Superoxide free radicals - possible role in the pathogenesis of the intestinal mucosal damage. Acta Chir Scand 150:301-309, 1984
4. Mustafa NA, Yandi M. Ovali E, et al: Role of diltiazem in ischemia-reperfusion injury of the intestine. Eur Surg Res 26:335-341, 1994
5. Otamiri T: Oxygen radicals, lipid peroxidation, and neutrophil infiltration after small-intestinal ischemia and reperfusion. Surgery 105:593-597. 1989
6. Frederiks WM, Marx F, Kooji A: The effect of ischemia on xanthine oxidase activity in rat intestine and liver. Int J Exp Pathol 74:21-25, 1993
7. Granger N: Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255:H1269-H1275, 1988
8. Van Ye TM, Roza AM, Pieper GM, et al: Inhibition of intestinal lipid peroxidation does not minimize morphologic damage. J Surg Res 55:553-558, 1993
9. Musemeche CA, Pizzini RP, Andrassy RJ: Intestinal ischemia in the newborn: The role of intestinal maturation. J Surg Res 55:595-598, 1993
10. Schmeling DJ. Caty MG, Oldham KT, et al: Cytoprotection by diclofenac sodium after intestinal ischemia/reperfusion injury. J Ped Surg 29:1044-1048, 1994
11. Musemeche CA, Henning SJ, Baker JL, et al: Inflammatory enzyme composition of the neonatal rat intestine: Implications for susceptibility to ischemia. J Ped Surg 28:778-791, 1993
12. Ward A, Clissold SP: Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34:50-97, 1987
13. Skjeldal S, Hvaal K, Nordsletten L, et al: Pentoxifylline reduces skeletal muscle necrosis after acute hindlimb ischemia in rats. Eur Surg Res 26:94-100, 1994
14. Chiu CJ, McArdle AH, Brown R, et al: Intestinal mucosal lesions in low-flow states. Arch Surg 101:478-483, 1970
15. Uchiyama M, Mihara M: Determination of malondialdehyde precursors in tissues by thiobarbituric acid test. Ann Biochem 86:271-278, 1978
16. Grisham MB, Hernandez LA. Granger DN: Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 251:G49-G53, 1987
17. Glowick SP, Kaplan SD: Methods in Enzymology. New York, NY, Academic Press, 1955, pp 769-782
18. Schoenberg MH, Fredholm BB, Haglund U, et al: Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage. Acta Physiol Scand 124:581-589, 1985
19. DiResta GR, Corbally MT, Sigurdson ER, et al: Infrared laser doppler flowmeter in the determination of small bowel perfusion after ischemic injury: Comparison with the clearance of locally generated hydrogen and fluorescein angiography. J Ped Surg 29:1352-1355, 1994
20. Canada AT, Coleman LR, Fabian MA, et al: Adenine nucleotides of ischemic intestine do not reflect injury. J Surg Res 55:416-421, 1993
21. Flynn WJ, Cryer HG, Garrison RN: Pentoxifylline restores intestinal microvascular blood flow during resuscitated hemorrhagic shock. Surgery 110:350-356, 1991
22. McMilen MA, Huribal M, Sumpio B: Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion. Am J Surg 166:557-562, 1993
23. Younes M, Schoenberg MH, Jung H. et al: Oxidative tissue damage following regional intestinal ischemia and reperfusion in the cat. Res Exp Med 184:259-264, 1984
24. Bradbury AW, Murie JA, Ruckley CV: Role of the leukocyte in the pathogenesis of vascular disease. Br J Surg 80:1503-1512, 1993