Pathophysiological significance of cerebral perfusion abnormalities in major depression-trait or state marker?

European Neuropsychopharmacology

Volumn 7, Issue 3, 1997, Pages 225-233

  Bonne, Omer ^a   Krausz, Yodphat ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Brain imaging; Cerebral blood flow; Depression; HMPAO; SPECT

Indexed keywords

FLUOXETINE; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN SCINTISCANNING; CLINICAL ARTICLE; DEPRESSION; DRUG EFFECT; ELECTROCONVULSIVE THERAPY; FEMALE; FOLLOW UP; HUMAN; ISOTOPE LABELING; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME;

ADULT; AFFECT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BIOLOGICAL MARKERS; CEREBROVASCULAR CIRCULATION; DEPRESSIVE DISORDER; ELECTROCONVULSIVE THERAPY; FEMALE; FLUOXETINE; HUMANS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0030986750     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(97)00410-0     Document Type: Article

References (68)

1. Ackerman, R.F., Engel, J. and Baxter, L. (1986) Positron emission tomography and autoradiographic studies of glucose utilization following electroconvulsive seizures in humans and rats. Ann. N.Y. Acad. Sci. 462, 263-269.
2. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn., revised. American Psychiatric Association, Washington, DC.
3. Austin, M.P., Dougall, N., Ross, M., O'Carrol, R.E., Mofoot, A., Ebmeir, K. and Goodwin, G.M. (1992) Single photon emission tomography with 99m Tc exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. J. Affect. Disord. 26, 31-43.
4. Baxter, L.R., Phelps, M.E., Maziotta, J.C., Schwartz, J.M., Gerner, R.H., Selin, C.E. and Sumida, R.M. (1985) Cerebral metabolic rates for glucose in mood disorders. Arch. Gen. Psychiatry 42, 441-447.
5. Baxter L.R., Schwartz, J.M., Phelps, M.E., Maziotta, J.C., Guze, B.H., Selin, C.E., Gerner, R.H. and Sumida, R.M. (1989) Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch. Gen. Psychiatry 46, 243-250.
6. Baxter L.R. (1990) Brain imaging as a tool in establishing a theory of brain pathology in obsessive-compulsive disorder. J. Clin. Psychiatry 51 (Suppl.), 22-25.
7. Bench, C.J., Friston, K.J., Brown, R.G., Scott, L.C., Frackowiak, R.S. and Dolan, R.J. (1992) The anatomy of cerebral blood flow in major depression. Psychol. Med. 22, 607-615.
8. Bench, C.J., Friston, K.J., Brown, R.G., Frackowiak, R.S.J. and Dolan, R.J. (1993) Regional cerebral flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol. Med. 23, 579-590.
9. Biver, F., Goldman, S., Delvenne, V., Luxen, A., DeMaertelaer, V., Hubain, P., Mendelewicz, J. and Lostra, F. (1994) Frontal and parietal metabolic disturbances in unipolar depression. Biol. Psychiatry 36, 381-388.
10. Bonne, O., Krausz, Y., Shapira, B., Bocher, M., Karger, H., Gorfine, M., Chisin, R. and Lerer, B. Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. (1996a) J. Nucl. Med. 37, 1075-1080.
11. Bonne, O., Krausz, Y., Gorfine, M., Karger, H., Gelfin, V., Shapira, B., Lerer, B., Chishin, R: Cerebral hypoperfusion in medication resistant, depressed patients assessed by Tc-99m HMPAO SPECT (1996b) J. Affect. Disord. 41, 163-171.
12. Buchsbaum, M.S., DeLisi, L.E., Holcomb, H.H., Cappelletti, J., King, A.C., Johnson, J., Hazlett, E., Dowling-Zimmerman, S., Post, R.M., Morhihisa, J.; Carpenter, W., Cohen, R., Pickar, D., Weiberger, D., Margolin, F. and Kessler, R. (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch. Gen. Psychiatry. 41, 1159-1166.
13. 18F]2-deoxyglucose in affective illness. J. Affect. Disord. 10, 137-152.
14. Chugani, H.T. (1992) The use of positron emission tomography in the clinical assessment of epilepsy. Semin. Nucl. Med. 22, 247-253.
15. Cohen, R.M., Semple, W.E., Gross, M., Nordhal, T.E., King, A.C., Pickar, D. and Post, R.M. (1989) Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology 2, 241-254.
16. Devous, M.D., Sr., Gullion, C.M., Grannemann, B.D., Trivedi, M.H. and Rush, A.J. (1993) Regional cerebral blood flow alterations in unipolar depression. Psychiatry Res. Neuroimaging, 50, 233-256.
17. Devous, M.D., Leroy, R.F. and Homan, R.W. (1990) Single photon computed emission tomography in epilepsy. Semin. Nucl. Med. 20, 325-341.
18. Duncan, R. (1992) Epilepsy, cerebral blood flow, and cerebral metabolic rate. Cerebrovasc. Brain Metab. Rev. 4, 105-121.
19. Duncan, S., Gillen, G., Adams, F.G., Duncan, R. and Brodie, M.J. (1992) Interictal HMPAO SPECT: a routine investigation in patients with medically intractable complex partial seizures. Epilepsy Res. 13, 83-87.
20. Ebert, D., Feistel, H. and Barocka, A. (1991) Effect of sleep deprivation on the limbic system and frontal lobes in affective disorders: a study with Tc-99m HMPAO SPECT. Psychiatry Res. Neuroimaging, 40, 247-251.
21. George, M.S., Ketter, T.A., Parekh, P.I., Horowitz, B., Herescovitch, P. and Post, R.M. (1995) Brain activity during transient sadness and happiness in healthy women. Am. J. Psychiatry 152, 341-351.
22. Ginsberg, M.D., Chang, J.Y., Kelly, R.E., Yoshii, F., Barker, W.W., Ingenito, G. and Boothe, T.E. (1988) Increases in both cerebral glucose utilization and blood flow during the execution of a somatosensory task. Ann. Neurol. 23, 153-157.
23. Goldstein, P.C., Brown, G.G., Welch, K.M.A., Marcus, A., Ewing, J.R. and Rosenbaum, G. (1985) Age related decline of rCBF in schizophrenia and major affective disorder. J. Cereb. Blood Flow Metab. 5, 203-204.
24. Gur, R.E., Skolnick, B.E., Gur, R.C., Caroff, S., Rieger, W., Obrist, W.D., Younkin, D. and Reivich, M. (1984) Brain function in psychiatric disorders. II: Regional cerebral blood flow in medicated unipolar depressives. Arch. Gen. Psychiatry 41, 695-699.
25. Guze, B.H., Baxter, L.R., Jr., Schwartz, J.M., Marcus, A., Ewing, J.R., Rosenbaum, G., Szuba, M.P. and Liston, E.H. (1991) Electroconvulsive therapy and brain glucose metabolism. Convulsive Ther. 7, 15-19.
26. Hamilton, M. (1960) A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56-62.
27. Hurwitz, T.A., Clark, C., Murphy, E., Klonoff, H., Martin, W.R. and Pate, B.D. (1990) Regional cerebral glucose activity in major depressive disorder. Can. J. Psychiatry 35, 684-688.
28. Ingvar, D.H. and Franzen, G. (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr. Scand. 50, 452-462.
29. Jagust, W.J., Reed, B.R., Martin, E.M., Eberling, J.L. and Nelson-Abbott, R.A. (1992) Cognitive function and regional cerebral blood flow in Parkinson's disease. Brain 115, 521-537.
30. Kanaya, T. and Yonekawa, M. (1990) Regional cerebral blood flow in depression. Jpn. J. Psychiatry Neurol. 44, 571-576.
31. Krausz, Y., Bonne, O., Yoffe, S., Marciano, R., Lerer, B. and Chisin R. (1996) SPECT imaging in neuropsychiatric disorders. Eur. J. Radiol. 21, 183-187.
32. Kuhl, D.E., Barrio, J.R., Huang, S.C., Selin, C., Ackerman, R.F., Lear, J.L., Wu, J.L., Lin, T.H. and Phelps, M.E. (1982) Quantifying local cerebral blood flow by N-isopropyl p-(123-I) iodoamphetamine (IMP) tomography. J. Nucl. Med. 23, 196-203.
33. Kung, H.F. (1990) New technetium 99m-labeled brain perfusion imaging agents. Semin. Nucl. Med. 20, 150-158.
34. Launes, J., Ilvanainen, M., Salmi, T., Nikkinen, P., Lindroth, L. and Liewendhal, K. (1992) Interictal brain Tc-99m HMPAO SPECT hypoperfusion in patients with unstable partial epilepsy and normal CT. Acta. Neurol. Scand. 86, 558-562.
35. Lebrun-Grandie, P., Baron, J.C., Soussaline, F., Loch'h, C., Sastre, J. and Bousser, M.G. (1983) Coupling between regional blood and oxygen utilization in the normal brain. Arch. Neurol. 40, 230-236.
36. Lee, B.I., Markland, O.N., Wellman, H.N., Siddiqui, A.R., Park, H.M., Mock, B., Worth, R.M., Edwards, M.K. and Krepshaw, J. (1988) HIDPM-SPECT in medically intractable complex partial seizures: Ictal study. Arch. Neurol. 45, 397-402.
37. Lesser, I.M., Mena, I., Boone, K.B., Miler, B.L., Mehringer, C.M. and Wohl, M. (1994) Reduction of cerebral blood flow in older depressed patients. Arch. Gen. Psychiatry 51, 677-686.
38. Martinot, J.L., Hardy, P., Feline, A., Huret, J.D., Mazoyer, B., Attar-Levy, D., Pappata, S. and Syrota, A. (1990) Left prefrontal glucose hypometabolism in the depressed state: A confirmation. Am. J. Psychiatry 147, 1313-1317.
39. Mathew, R.J., Meyer, J.S., Francis, D.J., Semchuk, K.M., Mortel, K. and Claghorn, J.L. (1980) Cerebral blood flow in depression. Am. J. Psychiatry 137, 1449-1450.
40. Mayberg, H.S. and Starkstein, S.E. (1991) Limbic cortex hypometabolism in depression: similarities among patients with Huntington's disease, Parkinson's disease and basal ganglia strokes (abstract). J. Cereb. Blood Flow Metab. 11, S2.
41. Mayberg, H.S. (1995) Neurological models of depression (abstract). 2nd Conference on New Directions in Affective Disorders, Jerusalem. 4-7 September, 1995.
42. Mayberg, H.S., Lewis, P.J., Regenold, W. and Wagner, H.N., Jr. (1994) Paralimbic hypoperfusion in unipolar depression. J. Nucl. Med. 35, 929-934.
43. Neirinckx, R.D., Canning, L.R., Piper, I.M., Nowotnik, D.P., Pickett, R.D., Holmes, R.A., Waker, W.A., Forster, A.M., Weisner, P.S. and Marriot, J.A. (1987) Technetium-99m D,L-HMPAO: A new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J. Nucl. Med. 28, 191-202.
44. Nobler, M.S., Sackeim, H.A., Prohovnik, I., Moeller, J.R., Mukherjee, S., Schnur, D.B., Prudic, J. and Devanand, D.P. (1994) Regional cerebral blood flow in mood disorders, III. Treatment and clinical response. Arch. Gen. Psychiatry 51, 884-897.
45. O'Connell, R.A., Van Heertum, R.L., Billick, S.B., Holt, A.R., Gonzalez, A., Notardonato, H., Luck, D. and King, L.N. (1989) Single photon emission computed tomography (SPECT) with 123-I-IMP in the differential diagnosis of psychiatric disorders. J. Neuropsychiatry 1, 145-153.
46. Pardo, J.V., Pardo, P.J. and Raichle, M.E. (1993) Neural correlates of self-induced dysphoria. Am. J. Psychiatry 150, 713-719.
47. Prohovnik, I., Sackeim, H.A., Decina, P. and Malitz, S. (1986) Acute reductions of regional cerebral blood flow following electroconvulsive therapy. Interactions with modality and time. Ann. N.Y. Acad. Sci. 462, 249-262.
48. Raichle, M.E., Grubb, R.L., Gado, M.H., Eichling, J.O. and Ter Pogossian, M.M. (1976) Correlation between regional cerebral blood flow and oxidative metabolism: In vivo studies in man. Arch. Neurol. 33, 523-537.
49. Renshaw, P.F., Johnson, K.A., Worth, J.L., Halman, M.H., Navia, B.A., Becker, J.A., Gonzalez, R.G. and Holman, B.L. (1992) New onset depression in patients with AIDS dementia complex (ADC) is associated with frontal lobe perfusion defects on HMPAO-SPECT (abstract), In: Abstracts of the American College of Neuropsychopharmacology. Nashville, TN, ACNP.
50. Ring, H.A., Bench, C.J., Trimble, M.R., Brooks, D.J., Frackowiak, R.S.J. and Dolan, R.J. (1994) Depression in Parkinson's disease. Br. J. Psychiatry 165, 333-339.
51. Robinson, R.G., Boston, J.D., Starktein, S.E. and Price, T.R. (1988) Comparison of mania and depression after brain injury: causal factors. Am. J. Psychiatry 145, 172-178.
52. Robinson, R.G. and Starkstein, S.E. (1989) Mood disorders following stroke: New findings and future directions. J. Geriatr. Psychiatry 22, 1-15.
53. Rosenberg, R., Vostrup, S., Andersen, A. and Bolwig, T. (1988) Effect of ECT on cerebral blood flow in melancholia assessed with SPECT. Convulsive Ther. 4, 62-73.
54. Rubin, R.T., Villanueva-Meyer, J., Ananth, J., Trajmar, PG. and Mena, I. (1992) Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Arch. Gen. Psychiatry 49, 695-702.
55. Rush, A.J., Schlesser, M.A., Stokely, E.M., Bonte, F.J. and Altshuler, K.Z. (1982) Cerebral blood flow in depression and mania. Psychopharmacol. Bull. 18, 6-8.
56. Sackeim, H.A., Prohovnik, I., Moeller, J.R., Brown, R.P., Apter, S., Prudic, J., Devanand, D.P. and Mukherjee, S.J.R. (1990) Regional cerebral blood flow in mood disorders. Arch. Gen. Psychiatry 47, 60-70.
57. Schlegel, S., Aldenhoff, J.B., Eissner, D., Lindner, P. and Nickel, O. (1989) Regional cerebral blood flow in depression: associations with psychopathology. J. Affect. Disord. 17, 211-218.
58. Silfverskiold, P., Gustafson, L., Risberg, J. and Rosen I. (1986) Acute and late effects of electroconvulsive therapy. Clinical outcome of regional cerebral blood flow, and electroencephalogram. Ann. N.Y. Acad. Sci. 462, 236-248.
59. Silfverskiold, P. and Risberg, J. (1989) Regional cerebral blood flow in depression and mania. Arch. Gen. Psychiatry 46, 253-259.
60. Sokoloff, L. (1981) Relationships among local functional activity, energy metabolism and blood flow in the central nervous system. Fed. Proc. 40, 2311-2314.
61. Starkstein, S.E., Robinson, R.G. and Price, T.R. (1987) Comparison of cortical and subcortical lesions in the production of post-stroke mood disorders. Brain 110, 1045-1059.
62. Starkstein, S.E., Bryer, J.B., Berthier, M.L., Cohen, B., Price, T.R. and Robinson, R.G. (1991) Depression after stroke: The importance of cerebral hemisphere asymmetries. J. Neuropsychiatry Clin. Neurosci. 3, 276-285.
63. Talairach, J., Zilkha, G., Tournoux, P., Prosalentis, A., Bordas-Ferrier, M., Covello, L., Iacob, M. and Mempel, E. (1988) Atlas d'Anatomie Stereotatactique du Telencephale. Masson, Paris.
64. Volk, S., Kaendler, S.H., Weber, R., Georgi, K., Maul, F., Hertel, A., Pflug, B. and Hor, G. (1992) Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photon emission computed tomography. Acta Psychiatr. Scand. 86, 478-483.
65. Volkow, N.D., Bellar, S., Mullani, N., Jould, L. and Dewey, S. (1988) Effects of electroconvulsive therapy on brain glucose metabolism: A preliminary study. Convulsive Ther. 4, 199-205.
66. Woods, S.W., Pearsall, H.R. and Siebyl, J.P. (1991) The Quinn essay: Single photon emission computed tomography in neuropsychiatric disorders. In: Hoffer, P.B. (Ed.), Year Book of Nuclear Medicine 1991. Mosby, St. Louis, MO, pp. xiii-xvii.
67. Wu, J.C., Gillin, J.C., Buchsbaum, M.S., Hershey, T., Johnson, J.C. and Bunney, W.E. (1992) Effect of sleep deprivation on brain metabolism of depressed patients. Am. J. Psychiatry, 149, 538-543.
68. Yazici, K.M., Kapucu, O., Erbas, B., Varoglu, E., Gulec, C. and Bekdik, C.F. (1992) Assessment of changes in regional cerebral blood flow in patients with major depression using the 99mTc-HMPAO single photon emission tomography method. Eur. J. Nucl. Med. 19, 1038-1043.