Myelodysplastic syndrome/acute myeloid leukemia supervening previously untreated chronic B-lymphocytic leukemia: Demonstration of the concomitant presence of two different malignant clones by immunologic and molecular analysis

Annals of Hematology

Volumn 74, Issue 4, 1997, Pages 193-197

  Mitterbauer, G ^a   Schwarzmeier, J ^a   Mitterbauer, M ^a   Jaeger, U ^a   Fritsch, G ^b   Schwarzinger, I ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

Chronic B lympohocytic leukemia; Clonal analysis; DXS 255 M27 ; IgH gene rearrangement; Secondary MDS AML

Indexed keywords

CD19 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; CD5 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; MICROSOMAL AMINOPEPTIDASE; PRIMER DNA;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ARTICLE; B CELL LEUKEMIA; BLAST CELL; BONE MARROW CELL; CASE REPORT; CELL STRUCTURE; CHRONIC LEUKEMIA; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOPHENOTYPING; METHYLATION; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFRACTORY ANEMIA; X CHROMOSOME INACTIVATION;

ACUTE DISEASE; AGED; BONE MARROW CELLS; FEMALE; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOPHENOTYPING; KARYOTYPING; LEUKEMIA, B-CELL, CHRONIC; LEUKEMIA, MYELOID; MYELODYSPLASTIC SYNDROMES; X CHROMOSOME;

EID: 0030986707     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050282     Document Type: Article

References (23)

1. Adriaansen HJ, Soeting PWC, Wolvers-Tettero ILM, van Dongen JJM (1991) Immunoglobulin and T-cell receptor gene rearrangements in acute non-lymphocytic leukemias. Analysis of 54 cases and a review of the literature. Leukemia 5:744-751
2. Bastion Y, Thomas X, Felman P, Campos L, Charrin C, Coiffier B (1991) High risk myelodysplastic syndrome coexistent with chronic lymphocytic leukemia for more than 9 years: inhibition of the myeloid clone by the lymphoid clone? Leukemia 5:1006-1009
3. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1984) Myelodysplastic syndromes: is another classification necessary? Br J Haematol 56:515-517
4. Bracey AW, Maddox AM, Immken L, Hsu SM, Marks ME (1989) Coexistence of myelodysplastic syndrome and untreated chronic lymphocytic leukemia with development of acute myeloid leukemia immediately after treatment of chronic lymphocytic leukemia. Am J Hematol 30:174-180
5. Catovsky D, Galton DAG (1971) Myelomonocytic leukaemia supervening on chronic lymphocytic leukaemia. Lancet I:478-479
6. Fey MF, Peter HJ, Hinds HL, Zimmermann A, Liechti-Gallati S, Gerber H, Studer H, Tobler A (1992) Clonal analysis of human tumors with M27β, a highly informative polymorphic X chromosomal probe. J Clin Invest 89:1438-1444
7. Fey MF, Liechti-Gallati S, von Rohr A, Borisch B, Theilkäs L, Schneider V, Oestreicher M, Nagel S, Ziemiecki A, Tobler A (1994) Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M 27β DNA probe. Blood 83:931-938
8. Foon KA, Thiruvengadam R, Saven A, Bernstein ZP, Gale RP (1993) Genetic relatedness of lymphoid malignancies. Ann Intern Med 119:63-73
9. + myeloid progenitors using CD45-RA analysis. Blood 81:2301-2309
10. Gale RE, Linch DC (1994) Investigation of methylation at Hha I sites using the hypervariable probe M27β allows improved clonal analysis in myeloid leukemia and demonstrates differences in methylation between leukemic and remission samples. Leukemia 8:190-194
11. Lawlor E, McCann SR, Whelan A, Greally J, Temperley IJ (1979) Acute myeloid leukaemia occurring in untreated chronic lymphatic leukaemia. Br J Haematol 43:369-373
12. Liang R, Chan V, Chan TK, Wong T, Chiu E, Lie A, Todd D (1993) Detection of immunoglobulin gene rearrangement in lymphoid malignancies of B-cell lineage by seminested polymerase chain reaction gene amplification. Am J Hematol 43:24-28
13. Manoharan A, Catovsky D, Clein P, Traub NE, Costello C, O'Brien M, Boralessa H, Galton DAG (1981) Simultaneous or spontaneous occurrence of lympho-and myeloproliferative disorders: a report of four cases. Br J Haematol 48:111-116
14. Roberts PD, Forster PM (1973) Chronic lymphocytic leukaemia associated with acute myelomonocytic leukaemia. Br J Haematol 25:203-206
15. Robertson LE, Estey E, Kantarjian H, Koller C, O'Brien S, Brown B, Keating MJ (1994) Therapy-related leukemia and myelodysplastic syndrome in chronic lymphocytic leukemia. Leukemia 8:2047-2051
16. Rozmann C, Montserrat E (1995) Current concepts: chronic lymphocytic leukemia. N Engl J Med 333:1052-1057
17. Sanchez I, San Miguel JF, Corral J, Martin C, Perez R, Gonzales M, Canizo MC, Orfao A, Gonzales-Sarmiento R (1995) Gene rearrangement in acute non-lymphoblastic leukaemia: correlation with morphological and immunophenotypic characteristics of blast cells. Br J Haematol 89:104-109
18. Shpilberg O, Mark Z, Biniaminov M, Rosner E, Gipsh N, Rubanov V, Rachmilewitz E, Brok-Simoni F, Rechavi G, Ben-Bassat I (1995) Transformation of chronic lymphocytic leukemia to multiple myeloma: clonal evolution or second malignancy? Leukemia 9:1974-1978
19. Sioutos N, Bagg A, Michaud G, Pugh WC, Luthra R, Locker J, Cossmann J (1993) PCR vs Southern blot (SB) hybridisation: detection of immunglobulin heavy chain (IgH) gene rearrangements. Blood 82:45a (abstr)
20. Stern N, Shemesh J, Ramot B (1981) Chronic lymphatic leukemia terminating in acute myeloid leukemia: review of the literature. Cancer 47:1849-1851
21. Trainor KJ, Brisco MJ, Wan JH, Neon S, Grist S, Morley AA (1991) Gene rearrangement in B-and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 78:192-196
22. Travis LB, Curtis RE, Hankey BF, Fraumeni JF jr (1992) Second cancers in patients with chronic lymphocytic leukemia. J Natl Cancer Inst 84:1422-1427
23. Wallis JP, Joyner MV (1986) Acute myeloid leukaemia developing in a patient with longstanding untreated chronic lymphocytic leukaemia. Acta Haematol 75:229-231