Effects of chemotherapy-induced testicular damage on inhibin, gonadotropin, and testosterone secretion: A prospective longitudinal study

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 3111-3115

  Wallace, Euan M ^a   Groome, Nigel P ^b   Riley, Simon C ^c   Parker, Alistair C ^c   Wu, Frederick C W ^d,e  

^a MONASH UNIVERSITY   (Australia)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADOTROPIN; INHIBIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; ALPHA CHAIN; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLITROPIN BLOOD LEVEL; FOLLITROPIN RELEASE; GONADOTROPIN RELEASE; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NEGATIVE FEEDBACK; PRIORITY JOURNAL; REGULATORY MECHANISM; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE METABOLISM; TESTOSTERONE RELEASE;

EID: 0030986516     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.9.4238     Document Type: Article

References (43)

1. Robertson DM, Risbridger GP, de Kretser DM. 1992 The physiology of testicular inhibin and related proteins. Bailliere's Clin Endocrinol Metab. 6:353-372.
2. Ishida H, Tashiro H, Watanabe M, et al. 1990 Measurement of inhibin concentrations in men: study of changes after castration and comparison with androgen levels in testicular tissue, spermatic venous blood, and peripheral venous blood. J Clin Endocrinol Metab. 70:1019-1022.
3. Abeyawardene SA, Plant TM. 1989 Institution of combined treatment with testosterone and charcoal-extracted porcine follicular fluid immediately after orchidectomy prevents the postcastration hypersecretion of follicle-stimulating hormone in the hypothalamus-lesioned rhesus monkey (Macaca mulatta) receiving an invariant intravenous gonadotropin-releasing hormone infusion. Endocrinology. 124:1310-1318.
4. Medhamurthy R, Culler MD, Gay VL, Negro-Vilar A, Plant TM. 1991 Evidence that inhibin plays a major role in the regulation of follicle-stimulating hormone secretion in the fully adult male rhesus monkey (Macaca mulatta). Endocrinology. 129:389-395.
5. Wallace EM, Healy DL. 1996 Inhibins and activins: roles in clinical practice. Brit J Obstet Gynaecol. 103:945-956.
6. de Kretser DM, McLachlan RI, Robertson DM, Burger HG. 1989 Serum inhibin levels in normal men and men with testicular disorders. J Endocrinol. 120:517-523.
7. Tsatsoulis A, Shalet SM, Morris ID, de Kretser DM. 1990 Immunoactive inhibin as a marker of Sertoli cell function following cytotoxic damage to the human testis. Horm Res. 34:254-259.
8. Tsatsoulis A, Shalet SM, Robertson WR, Morris ID, Burger HG, de Kretser DM. 1988 Plasma inhibin levels in men with chemotherapy-induced severe damage to the seminiferous epithelium. Clin Endocrinol (Oxf). 29:659-665.
9. Schneyer AL, Mason AJ, Burton LE, Zeigner JR, Crowley WF Jr. 1990 Immunoreactive inhibin α-subunit in human serum: Implications for radioimmunoassay. J Clin Endocrinol Metab. 70:1208-1212.
10. Burger HG. 1993 Clinical utility of inhibin measurements. J Clin Endocrinol Metab. 76:1391-1396.
11. Groome NP, O'Brien M. 1993 Two-site immunoassays for inhibin and its subunits. Further applications of the synthetic peptide approach. J Immunol Methods. 165:167-176.
12. Groome NP, Illingworth PJ, O'Brien M, et al. 1996 Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab. 81:1401-1405.
13. Groome NP, Illingworth PJ, O'Brien M, Priddle J, Weaver K, McNeilly AS. 1995 Quantification of inhibin pro-αC containing forms in human serum by a new ultrasensitive two-site enzyme-linked immunosorbent assay. J Clin Endocrinol Metab. 80: 2926-2932.
14. Groome NP, Illingworth PJ, O'Brien M, et al. 1994 Detecion of dimeric inhibin throughout the menstrual cycle by two-site enzyme immunoassav. Clin Endocrinol (Oxf). 40:717-723.
15. Groome NP, Illingworth PJ, O'Brien M, et al. 1996 Measurement of dimeric inhibin B throughout the human menstrual cylce. J Clin Endocrinol Metab. 81: 1401-1405.
16. Wallace EM, Riley SC, Crossley JA, et al. 1997 Dimeric inhibins in amniotic fluid and maternal and fetal serum in human pregnancy. J Clin Endocrinol Metab. 82:218-222.
17. Illingworth PJ, Groome NP, Byrd W, et al. 1996 Inhibin B: a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab. 81: 1321-1325.
18. Anderson RA, Wallace EM, Groome NP, Bellis AJ, Wu FCW. 1997 Physiological relationships between inhibin B, follicle stimulating hormone secretion and spermatogenesis in normal men and response to gonadotrophin suppression by exogenous testosterone. Hum Reprod. 12:746-751.
19. Anawalt BD, Bebb RA, Matsumoto AM, et al. 1996 Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab. 81:3341-3345.
20. Riley SC, Wathen NC, Chard T, Groome NP, Wallace EM. 1996 Inhibin in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy. Hum Reprod. 11:2722-2776.
21. Robertson DM, Cahir N, Findlay JK, Burger HG, Groome NP. 1997 The biological and immunological charactersation of inhibin A and B forms in human follicular fluid and plasma. J Clin Endocrinol Metab. 82:889-896.
22. McLachlan RI, Robertson DM, Healy DL, Burger HG, de Kretser DM. 1987 Circulating immunoreactive inhibin levels during the normal human menstrual cycle. J Clin Endocrinol Metab. 65:954-961.
23. Lambert-Messerlian GM, Isaacson K, Crowley WF, Sluss P, Schneyer AL. 1994 Human follicular fluid contains pro- and C-terminal immunoreactive α-inhibin precursor proteins. J Clin Endocrinol Metab. 78:433-439.
24. Hunter WM, Bennie JG. 1979 Reduction of non-specific serum responses in human pituitary gonadotrophin radioimmunoassay. J Endocrinol. 80:59-68.
25. Corker CS, Davidson DW. 1978 Radioimmunoassay of testosterone in various biological fluids without chromatography. J Steroid Biochem. 9:373-374.
26. Mottram JC, Cramer TV. 1923 On the general effects of exposure to radium on metabolism and tumor growth in the rat and the special effects on testis and pituitary. Q J Exp Physiol. 13:209-229.
27. McCullagh DR. 1932 Dual endocrine activity of the testis. Science. 76:19-20.
28. Nachtigall LB, Boepple PA, Seminara SB, et al. 1996 Inhibin B secretion in males with gonadotrophin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment - a clinical research center study. J Clin Endocrinol Metab. 81:3520-3525.
29. Risbridger GP, Clements JA, Robertson DM, et al. 1989 Immuno- and bioactive inhibin and inhibin α subunit expression in rat Leydig cell culures. Mol Cell Endocrinol. 66:119-122.
30. Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG. 1982 The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer. 49:418-422.
31. Chapman RM, Sutcliffe SB, Rees LH, Edwards CRW, Malpas JS. 1979 Cyclical combination chemotherapy and gonadal function. Retrospective study in males. Lancet. i:284-289.
32. Booth JD, Merriam GR, Clark RV, Loriaux DL, Sherins RJ. 1987 Evidence for Leydig cell dysfunction in infertile men with a selective increase in plasma follicle-stimulating hormone. J Clin Endocrinol Metab. 64:1194-1198.
33. Dong Q, Hawker F, McWilliam D, Bangah M, Burger H, Handelsman DJ. 1992 Circulating immunoreactive inhibin and testosterone levels in men with critical illness. Clin Endocrinol (Oxf). 36:399-404.
34. Feng ZM, Bardin CW, Chen CLC. 1989 Characterisation and regulation of testicular inhibin β-subunit mRNA. Mol Endocrinol. 3:939-948.
35. Toebosch AMW, Robertson DM, Trapman J, et al. 1988 Effects of FSH and IGF-I on immature rat Sertoli cells: inhibin α- and β-subunit mRNA levels and inhibin secretion. Mol Cell Endocrinol. 55:101-105.
36. Hancock AD, Robertson DM, de Kretser DM. 1992 Inhibin and inhibin α-chain precursors are produced by immature rat Sertoli cells in culture. Biol Reprod. 46:155-161.
37. Majumdar SS, Winters SJ, Plant TM. 1997 A study of the relative roles of follicle-stimulating hormone and luteinising hormone in the regulation of testicular inhibin secretion in the rhesus monkey (Macaca mulatta). Endocrinology. 138:1363-1373.
38. Bergh A, and Cajander S. 1990 Immunohistochemical localization of inhibin-alpha in the testes of normal men and in men with testicular disorders. Int J Androl. 13:463-469.
39. Chapman RM, Sutcliffe SB, Malpas JS. 1981 Male gonadal dysfunction in Hodgkin's disease. JAMA 245:1323-1326.
40. Hendry WF, Stedronska J, Jones CR, Blackmore CA, Barrett A, Peckham MJ. 1983 Semen analysis in testicular cancer and Hodgkin's disease: pre- and post-treatment findings and implications for cryopreservntion. Brit J Urol. 55:769-773.
41. Miller DG. 1971 Alkylating agents and human spermatogenesis. JAMA 217:1662-1665.
42. Roeser HP, Stocks AE, Smith AJ. 1978 Testicular damage due to cytotoxic drugs and recovery after cessation of therapy. Aust NZ J Med. 8: 250-254.
43. Waxman J. 1985 Cancer, chemotherapy and fertility. BMJ 290:1096-1097.