The expression and activity of prostaglandin H synthase-2 is enhanced in trophoblast from women with preeclampsia

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 3059-3062

  Johnson, Roger D ^a   Sadovsky, Yoel ^a   Graham, Carol ^a   Anteby, Eyal Y ^a   Polakoski, Kenneth L ^a   Huang, Xiaohua ^a   Nelson, D Michael ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dept of Obstetrics and Gynecology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTANOID; THROMBOXANE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME POLYMORPHISM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; PLACENTA VILLUS; PREECLAMPSIA; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; TROPHOBLAST;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; ISOENZYMES; NITROBENZENES; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REFERENCE VALUES; RNA, MESSENGER; SULFONAMIDES; TROPHOBLASTS;

EID: 0030986514     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.9.3059     Document Type: Article

References (16)

1. Sibai BM. 1996 Treatment of hypertension in pregnant women. N Engl J Med. 335:257-265.
2. Walsh SW. 1985 Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. Am J Obstet Gynecol. 152:335-340.
3. American College of Obstetrics, and Gynecology Technical Bulletin. 1996 Hypertension in pregnancy. 219 (January).
4. Johnson RD, Walsh SW, Everson WV, Nelson DM. 1995 Differentiation and growth on a fibrin matrix modulate the cyclooxygenase expression and thromboxane production by cultured human placental trophoblasts. Prostaglandins Leukot Essent Fatty Acids. 52:21-27.
5. Ding ZQ, Rowe J, Sinosich MJ, Saunders DM, Gallery EDM. 1996 In-vitro secretion of prostanoids by placental villous cytotrophoblasts in pre-eclampsia. Placenta. 17:407-411.
6. Smith WL, DeWitt DL. 1996 Prostaglandin endoperoxide H synthases 1 and 2. Advance Immunol. 62:167-215.
7. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss III, JF. 1996 Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118:1567-1582.
8. Church SL, Farmer DR, Nelson DM. 1992 Induction manganese superoxide dismutase in cultured human trophoblast during in vitro differentiation. Dev Biol. 149:177-184.
9. Farmer DR, Nelson DM. 1992 A fibrin matrix modulates the proliferation, hormone secretion and morphologic differentiation of cultured human placental trophoblast. Placenta. 13:163-177.
10. Endo T, Ogushi F, Sone S. 1996 LPS-dependent cyclooxygenase-2 induction in human monocytes is down-regulated by IL-13, but not by IFN-γ. J Immunol. 156:2240-2246.
11. 2 in the vasoconstrictor response to endothelin-1, angiotensin II and 5-hydroxytryptamine in human placental vessels. Placenta. 16:679-689.
12. Nelson DM, Walsh SW. 1989 Thromboxane and prostacyclin production by different compartments of the human placental villus. J Clin Endocrinol Metab. 68:676-683.
13. Woodworth SH, Li X, Lei ZM, et al. 1994 Eicosanoid biosynthetic enzymes in placental and decidual tissues from preeclamptic pregnancies: Increased expression of thromboxane-A2 synthase gene. J Clin Endocrinol Metab. 78:1225-1231.
14. Hauth JC, Cunningham FG. 1995 Low-dose aspirin during pregnancy. In: Cunningham FG, MacDonald PC, Gant NS, Leveno KJ, Gilstrap LC, eds. Williams Obstetrics Supplement 14, August/September. Ortho Pharmaceutical Corporation, Raritan, New Jersey.
15. Bower SJ, Harrington KF, Schuchter K, McGirr C, Campbell S. 1996 Prediction of pre-eclampsia by abnormal uterine Doppler ultrasound and modification by aspirin. Brit J Obstet Gynaecol. 103:625-629.
16. Caritis SN. 1997 Low dose aspirin does not prevent preeclampsia in high risk women. Am J Obstet Gynecol. 176:53 (Abstract).