Dehydroepiandrosterone treatment is not beneficial to the immune response to influenza in elderly subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 2911-2914

  Danenberg, H D ^a   Ben Yehuda, A ^a   Zakay Rones, Z ^b   Gross, D J ^a   Friedman, G ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; PRASTERONE;

ADULT; AGED; AGING; ANTIBODY TITER; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HORMONAL THERAPY; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; INFLUENZA; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; AGING; ANTIBODY FORMATION; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DOUBLE-BLIND METHOD; DRUG SYNERGISM; FEMALE; HUMANS; HYDROCORTISONE; IMMUNE SYSTEM; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; VACCINATION;

RODENTIA;

EID: 0030986512     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.9.2911     Document Type: Article

References (28)

1. Kohn RP. 1982 Cause of death in very old people. JAMA. 247:2793-2797.
2. Gross PA, Hermogenes AW, Sacks HS, et al. 1995 The efficacy of influenza vaccine in the elderly, a meta-analysis and review of the literature. Arch Int Med. 123:518-527.
3. Govaert TME, Sprenger MJW, Dinant GJ, et al. 1994 Immune response to influenza vaccination of elderly people. A randomized double blind placebo-controlled trial. Vaccine. 12:1185-1189.
4. Setia U, Serventi I, Lorenz P. 1985 Factors affecting the use of influenza vaccine in institutionalized elderly. J Am Geriatr Soc. 33:856-858.
5. Makinodan T, Kay MMB. 1980 Age influence on the immune system. Adv Immunol. 29:287-330.
6. Miller RA. 1996 The aging immune system: primer and prospectus. Science. 273:70-74.
7. Ben-Yehuda A, Ehlieter D, Hu AR, Wexler ME. 1993 Recombinant vaccinia virus expressing PR/8 Influenza hemagglutinin gene overcomes the impaired immune response and increased susceptibility of old mice to influenza infection. J Inf Dis. 168:52-57.
8. Couch RB. 1993 Advances in influenza virus vaccine research. Ann NY Acad Sci. 685:803-812.
9. Remarque EJ, van-Beek WC, Ligthart GJ, et al. 1993 Improvement of the immunoglobulin subclass response to influent vaccine in elderly nursing home residents by the use of high dose vaccines. Vaccine. 11:649-654.
10. Orentreich N, Brind JL, Rizer RL, Vogelman JH. 1984 Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 59:551-555.
11. Daynes RA, Araneo BA. 1992 Prevention and reversal of some age-associated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging: Immunol and Inf Dis. 3:135-154.
12. Araneo B, Marion L, Woods H, Daynes RA. 1993 Reversal of the immunosenenescent phenotype by dehydroepiandrosterone: hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen. J Inf Dis. 167:830-840.
13. Danenberg HD, Ben-Yehuda A, Zakay-Rones Z, Friedman G. 1995 Dehydroepiandrosterone reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine. 15:1445-1448.
14. US Department of Health, Education, and Welfare. 1975 Advanced laboratory techniques for influenza diagnosis. Immunology series 6. Procedural guide. Washington DC: USDHEW 25-61.
15. Beyer WEP, Palache AM, Baldjet M, Masurel N. 1989 Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine. 7:385-394.
16. Araneo B, Dowell T, Woods ML, et al. 1995 DHEAS as an effective adjuvant in elderly humans. Proof-of-principle studies. Ann NY Acad Sci. 774:232-248.
17. Casson PR, Andersen RN, Henry GH, et al. 1993 Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol. 169:1536-1539.
18. Van-Vollenhoven RF, Engleman EG, McGuire JL. 1994 An open study of dehydroepiandrosterone in systemic lupus erythematosus. Arthritis Rheum. 37:1305-1310.
19. Suzuki T, Suzuki N, Daynes RA, Engelman EG. 1991 Dehydroepiandrosterone enhances IL-2 production and eytotoxic effector function of human T cells. Clin Immunol Immunopathol. 61:202-211.
20. Karupiah G, Woodhams CE, Blanden RV, Ramshaw IA. 1991 Immunubiology of infection with recombinant vaccinia virus encoding murine IL-2. Mechanism of rapid viral clearance in immunocompetent mice. J Immunol. 147:4327-4332.
21. Gordon GB, Bush DE, Weisman HF. 1988 Reduction of atherosclerosis by administration of dehydroepiandrosterone: a study in the hypercholesterolemic New Zealand white rabbit with aortic intimai injury. J Clin Invest. 82:712-720.
22. vv/a) mice by long-term treatment with dehydroepiandrosterone. Carcinogenesis (Lond.). 2:1335-1337.
23. Ratko TA, Detrisac CJ, Mehta RG, et al. 1991 Inhibition of rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone. Cancer Res. 51:481-486.
24. van-Weerden WM, Bierings HG, van-Steenbrugge GJ, et al. 1992 Adrenal glands of mouse and rat do not synthesize androgens. Life Sci. 50: 857-861.
25. Govaert TME, Dinant GJ, Aretz K, et al. 1993 Adverse reactions to influenza vaccine in elderly people: randomized double blind placebo controlled trial. BMJ. 307:988-990.
26. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. 1994 Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. 78:1360-1367.
27. Barett-Connor E, Khaw KT, Yen SSC. 1986 A prospective study of dehydroepuindrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med. 315:1519-1524.
28. Nestler JE. 1995 DHEA: a coming age. Ann NY Acad Sci. 774:ix-xi.