Effects of nicergoline on age-related decrements in radial maze performance and acetylcholine levels

Brain Research Bulletin

Volumn 43, Issue 3, 1997, Pages 305-311

  McArthur, Robert A ^a   Carfagna, Nicola ^a   Banfi, Laura ^a   Cavanus, Stefano ^a   Cervini, Maria Antonietta ^a   Fariello, Ruggero ^a   Post, Claes ^a  

^a PFIZER INC   (United States)

Author keywords

Aging; Brain regions; Locomotor activity; Radial maze; Rat strains

Indexed keywords

ACETYLCHOLINE; NICERGOLINE;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; LOCOMOTION; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; TRAINING;

ACETYLCHOLINE; AGING; ANIMALS; BRAIN; MAZE LEARNING; NICERGOLINE; RATS; RATS, WISTAR;

EID: 0030986371     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00010-5     Document Type: Article

References (51)

1. Arrigo A., Moglia A., Borsotti L., Massarini M., Alfonsi E., Battaglia A., Sacchetti G. A. Double-blind, placebo controlled, crossover trial with nicergoline in patients with senile dementia. Int. J. Clin. Pharmacol. Res. II:((Suppl. 1)):1982;33-41.
2. 1-like receptors and molecular mechanisms of incentive learning. Beninger R. J., Palomo T., Archer T. Dopamine disease states: Strategies for studying brain disorders. 3:1996;407-431 Editorial CYM, Madrid.
3. Benzi G., De Bernardi M., Manzo L., Ferrara A., Panceri P., Arrigoni E., Berte F. Effect of lysergide and nicergoline on glucose metabolism investigated on the dog brain isolated in situ. J. Pharm. Sci. 61:1972;348-352.
4. Biegon A., Greenberger V., Segal M. Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat. Neurobiol. Aging. 7:1986;215-217.
5. Blaker W. D., Peruzzi G., Costa E. Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat. Proc. Natl. Acad. Sci. USA. 81:1984;1880-1882.
6. Carfagna N., DiClemente A., Cavanus S., Damiani D., Gerna M., Salmoiraghi P., Cattaneo B., Post C. Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci. Lett. 197:1995;195-198.
7. Carfagna N., Cavanus S., Damiani D., Salmoiraghi P., Fariello R., Post C. Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci. Lett. 209:1996;189-192.
8. Chouinard M. L., Gallagher M., Yasuda R. P., Wolfe B. B., McKinney M. Hippocampal muscarinic receptor function in spatial learning-impaired aged rats. Neurobiol. Aging. 16:1995;955-963.
9. Davies P. A. critical review of the role of the cholinergic system in human memory and cognition. Ann. NY Acad. Sci. 444:1985;212-217.
10. Di Luca M.; Caputi L.; Pastorino N.; Carfagna N.; Wong E.; Post C.; Catabeni F. Mechanism of action of nicergoline: Possible involvement of phosphorylation processes in the CNS. Paper presented at the Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy. Nice, France; April 10-14, 1996.
11. Drachman D. A., Sahakian B. J. Effects of cholinergic agents on human learning and memory. Barbeau A., Growdon J. H., Wurtman R. J. Nutrition and the brain. 2:1979;351-365 Raven Press, New York.
12. Dunnett S. B. Comparative effects of cholinergic drugs and lesions on nucleus basalis or fornix-fimbria on delayed matching in rats. Psychopharmacology (Berlin). 87:1985;357-363.
13. Friedland R. P. Alzheimer's disease: Clinical features and differential diagnosis. Neurology. 43:((Suppl. 4)):1993;S45-S51.
14. Gage F. H., Dunnett S. B., Bjorklund A. Spatial learning and motor deficits in aged rats. Neurobiol. Aging. 5:1984;43-48.
15. Gauthier S., Bouchard R., Lamontagne A., Bailey P., Bergman H., Ratner J., Tesfaye Y., Saint-Martin M., Bacher Y., Carrier L., Charbonneau R., Clarfield A. M., Collier B., Dastoor D., Gauthier L., Germain M., Kissel C., Krieger M., Kushnir S., Masson H., Morin J., Nair V., Neirinck L., Suissa S. Tetrahydroaminoacridine-lecethin combination treatment in patients with intermediate-stage Alzheimer's disease. N. Engl. J. Med. 322:1990;1272-1276.
16. Glowinski J., Iversen L. L. Regional studies of catacholamines in the rat brain. J. Neurochem. 13:1966;655-669.
17. Hagan J. J., Morris R. G. M. The cholinergic hypothesis of memory: A review of animal experiments. Iversen L. L., Iversen S. D., Snyder S. H. Handbook of psychopharmacology. 20:1988;237-323 Plenum Press, New York.
18. Haroutunian V., Davis K. L., Davis B. M., Horvath T. B., Johns C. A., Mohs R. C. The study of cholinomimetics in Alzheimer's disease and animal models. Iversen S. D. Psychopharmacology: Recent advances and future prospects. 1985;170-181 Oxford University Press, Oxford.
19. Henderson A. S. The epidemiology of Alzheimer's disease. Br. Med. Bull. 42:1986;3-10.
20. Ingram D. K. Analysis of age-related impairments in learning and memory in rodent models. Olton D. S., Gamzu E., Corkin S. Memory dysfunctions: An integration of animal and human research from preclinical and clinical perspectives. 1985;312-332 The New York Academy of Sciences, New York.
21. Ingram D. K., London E. D., Goodrick C. L. Age and neurochemical correlates of radial maze performance in rats. Neurobiol. Aging. 2:1981;41-47.
22. Ingram D. K., London E. D., Reynolds M. A., Waller S. B., Goodrick C. L. Differential effects of age on motor performance in two mouse strains. Neurobiol. Aging. 2:1981;221-227.
23. Jope R. S., Song L., Li X., Powers R. Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol. Aging. 15:1994;221-226.
24. Kirk R. E. Experimental design: Procedures for the behavioral sciences. 1968;Brooks- Cole Publishing Company, Belmont, CA.
25. Knapp M. J., Knopman D. S., Solomon P. R., Pendlebury W. W., Davis C. S., Gracon S. L. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 271:1994;985-991.
26. Kudo Y., Ego H., Ishida R. Effects of nicergoline on memory retention and scopolamine-induced amnesia: Study with one-trial passive avoidance task in mice. Jpn. Pharmacol. Ther. 13:1985;201-205.
27. Le Poncin-Lafitte M., Grosdemouge C., Duterte D., Rapin J. R. Simultaneous study of haemodynamic, metabolic and behavioural sequelae in a model of cerebral ischaemia in aged rats: Effects of nicergoline. Gerontology. 30:1984;109-119.
28. Matsuoka Y., Fukushima T., Iwata H., Matsumoto M., Shibutani Y., Kawashima K., Kudo Y., Ishida R. An inhibitory action of nicergoline and its major metabolites on acetylcholinesterase activity in rat and mouse brain. Adv. Behav. Biol. 38B:1990;415-419.
29. Meek J. L., Bertilsson L., Cheney D. L., Zsilla G., Costa E. Aging-induced changes in acetylcholine and serotonin content of discrete brain nuclei. J. Gerontol. 2:1977;129-131.
30. Moretti A., Carfagna N., Caccia C., Carpentieri N., Amico A., Marchi G., Trunzo F. Neurochemical effects of ergoline derivatives. Heidrich H. Proof of therapeutical effectiveness of nootropic and vasoactive drugs. 1986;103-110 Springer Verlag, Berlin.
31. Moretti A., Carfagna N., Caccia C., Carpentieri M. Effect of ergolines on neurotransmitter systems in the rat brain. Arch. Int. Pharmacodyn. Ther. 294:1988;33-45.
32. Ogawa N., Asanuma M., Hirata H., Konodo Y., Kawada Y., Mori A. Cholinergic deficits in aged rat brain are corrected with nicergoline. Arch. Gerontol. Geriatr. 16:1993;103-110.
33. Olds J. L., Anderson M. L., McPhie D. L., Staten L. D., Alkon D. L. Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus. Science. 245:1989;866-869.
34. Porsolt R., Roux S., Lenègre A. Critical issues in cognition enhancing drug research. Palomo T., Archer T., Beninger R. Strategies for studying brain disorders. 2:1994;285-299 Farrand Press, London.
35. Potter P. E., Meek J. L., Neff N. H. Acetylcholine and choline in neuronal tissue measured by HPLC with electrochemical detection. J. Neurochem. 41:1983;188-194.
36. Rossi A., Battaglia A., Novellini R., Buonamici M., Carfagna N., Orlando N., Pamparana F. Nicergoline: Pharmacological properties and clinical studies in aging brain. Aging brain and dementia: New trends in diagnosis and therapy. 1990;549-578 Alan R. Liss, Inc, New York.
37. Saletu B., Grünberger J. Memory dysfunction and vigilance: Neurophysiological and psychpharmacological aspects. Ann. NY Acad. Sci. 444:1985;406-427.
38. Saletu B., Anderer A., Grünberger J. Topographic brain mapping of EEG after acute application of ergotalkaloids in the elderly. Arch. Gerontol. Geriatr. 11:1990;1-22.
39. Saletu B., Grünberger J., Lintzmayer L., Anderer A. Brain protection of nicergoline against hypoxia: EEG brain mapping and psychometry. J. Neural. Transm. [P-D Sect]. 2:1990;305-325.
40. Sarter M., Hagan J., Dudchenko P. Behavioral screening for cognitive enhancers: From indiscriminate to valid testing: Part 1. Psychopharmacology (Berlin). 107:1992;144-159.
41. Schindler U., Rush D. K., Fielding S. Nootropic drugs: Animal models for studying effects on cognition. Drug Dev. Res. 4:1984;567-576.
42. Schneider L. S. Clinical pharmacology of aminoacridines in Alzheimer's disease. Neurology. 43:((Suppl. 4)):1993;S64-S79.
43. Strong R., Hicks P., Hsu L., Bartus R. T., Enna S. J. Age-related alterations in the rodent brain cholinergic system and behavior. Neurobiol. Aging. 1:1980;59-63.
44. Summers W. K., Majovski L. V., Marsh G. M., Tachiki T., Kling A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia; Alzheimer type. N. Engl. J. Med. 315:1986;1241-1245.
45. Sunayashiki-Kusuzaki K., Lester D. S., Schreurs B. G., Alkon D. L. Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus. Proc. Natl. Acad. Sci. USA. 90:1993;4286-4289.
46. Voronina T. A., Nerobkova L. N., Garibova T. L., Dikova M., Nikolov R., Nikolova M., Markina N. V. Effect of nicergoline on learning and memory. Methods Find. Exp. Clin. Pharmacol. 10:1988;431-435.
47. Watkins P. B., Zimmerman H. J., Knapp M. J., Gracon S. I., Lewis K. W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA. 271:1994;992-998.
48. Weiler M. Acetylcholine release from striatal slices of young adult and aged Fisher 344 rats. Neurobiol. Aging. 11:1990;401-407.
49. Whitehouse P. J., Price D. L., Struble R. G., Clark A. W., Coyle J. T., Delong M. R. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science. 215:1982;1237-1239.
50. Willig F., Palacios A., Monmaur P., M'Harzi M., Laurent J., Delacour J. Short-term memory, exploration and locomotor activity in aged rats. Neurobiol. Aging. 8:1987;393-402.
51. Zappoli R., Arnetoli G., Paganini M., Battaglia A., Novellini R., Pamparana F. Topographic bit-mapped event-related neurocognitive potentials and clinical status in patients with primary presenile mental decline chronically treated with nicergoline. Curr. Ther. Res. 49:1991;1078-1097.