메뉴 건너뛰기




Volumn 71, Issue 5, 1997, Pages 271-282

Observation of hepatotoxic effects of 2-n-pentylaminoacetamide (Milacemide) in rat liver by a combined in vivo/in vitro approach

Author keywords

2 n Pentylaminoacetamide hydrochloride; Hepatocytes; Hepatotoxicity; Liver cells; Milacemide

Indexed keywords

FAT DROPLET; LIVER ENZYME; MILACEMIDE;

EID: 0030986125     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050387     Document Type: Article
Times cited : (3)

References (39)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 2
    • 0016333916 scopus 로고
    • Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
    • Burke MD, Mayer RT (1974) Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab Dispos 2: 583-588
    • (1974) Drug Metab Dispos , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 4
    • 84878803927 scopus 로고
    • Conversion of orally administered 2-n-pentylaminoacetamide into glycinamide and glycine in the rat brain
    • Christophe J, Kutzner R, Nguyen-Bui WD, Damien C, Chatelain P, Gillet C (1983) Conversion of orally administered 2-n-pentylaminoacetamide into glycinamide and glycine in the rat brain. Life Sci 33: 533-541
    • (1983) Life Sci , vol.33 , pp. 533-541
    • Christophe, J.1    Kutzner, R.2    Nguyen-Bui, W.D.3    Damien, C.4    Chatelain, P.5    Gillet, C.6
  • 8
    • 0023864274 scopus 로고
    • Valproate-associated hepatotoxicity and its biochemical mechanisms
    • Eadie MJ, Hooper WD, Dickinson RG (1988) Valproate-associated hepatotoxicity and its biochemical mechanisms. Med Toxicol 3: 85-106
    • (1988) Med Toxicol , vol.3 , pp. 85-106
    • Eadie, M.J.1    Hooper, W.D.2    Dickinson, R.G.3
  • 9
    • 0021247498 scopus 로고
    • 7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: Regulation in cultured rat hepatocytes
    • Edwards AM, Glistak ML, Lucas CM, Wilson PA (1984) 7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: regulation in cultured rat hepatocytes. Biochem Pharmacol 33: 1537-1546
    • (1984) Biochem Pharmacol , vol.33 , pp. 1537-1546
    • Edwards, A.M.1    Glistak, M.L.2    Lucas, C.M.3    Wilson, P.A.4
  • 11
    • 0020620574 scopus 로고
    • Radiometric assays for mammalian epoxide hydrolase and glutathione S-transferase
    • Gill S, Ota K, Hammock BD (1983) Radiometric assays for mammalian epoxide hydrolase and glutathione S-transferase. Anal Biochem 131: 273-282
    • (1983) Anal Biochem , vol.131 , pp. 273-282
    • Gill, S.1    Ota, K.2    Hammock, B.D.3
  • 12
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig WG, Pabst MJ, Jacoby W (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.G.1    Pabst, M.J.2    Jacoby, W.3
  • 16
    • 0025313982 scopus 로고
    • The cytochrome P-450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals
    • Ioannides C, Parke DV (1986) The cytochrome P-450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev 22: 1-85
    • (1986) Drug Metab Rev , vol.22 , pp. 1-85
    • Ioannides, C.1    Parke, D.V.2
  • 18
    • 0025160945 scopus 로고
    • Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of Rhesus monkey
    • Janssens de Varebeke Ph, Schallauer E, Rausch WD, Riederer P, Youdim MBH (1990) Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of Rhesus monkey. Neurochem Int 17: 325-329
    • (1990) Neurochem Int , vol.17 , pp. 325-329
    • Janssens De Varebeke, Ph.1    Schallauer, E.2    Rausch, W.D.3    Riederer, P.4    Youdim, M.B.H.5
  • 19
    • 0021646542 scopus 로고
    • The hepatotoxicity of valproic acid and its metabolites in rats. I . Toxicologic, biochemical and histopathologic studies
    • Kesterson JW, Granneman GR, Machinist JM (1984) The hepatotoxicity of valproic acid and its metabolites in rats. I . Toxicologic, biochemical and histopathologic studies. Hepatology 4: 1143-1152
    • (1984) Hepatology , vol.4 , pp. 1143-1152
    • Kesterson, J.W.1    Granneman, G.R.2    Machinist, J.M.3
  • 20
    • 0017881610 scopus 로고
    • The contribution of serum triglycerol to hepatic triacylglycerol turnover in the starved rat
    • Lipkin EW, Cooper C, Shipley RA (1978) The contribution of serum triglycerol to hepatic triacylglycerol turnover in the starved rat. Biochem J 172: 205-218
    • (1978) Biochem J , vol.172 , pp. 205-218
    • Lipkin, E.W.1    Cooper, C.2    Shipley, R.A.3
  • 21
    • 0021981951 scopus 로고
    • Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenazones in hepatic S9s and hepatocyte homogenates: Effects of dicumarol
    • Lubet RA, Nims RW, Mayer RT, Cameron JW, Schechtman LM (1985) Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol. Mutat Res 42: 127-131
    • (1985) Mutat Res , vol.42 , pp. 127-131
    • Lubet, R.A.1    Nims, R.W.2    Mayer, R.T.3    Cameron, J.W.4    Schechtman, L.M.5
  • 22
    • 0021183591 scopus 로고
    • Differences between small and large intestine and liver in the inducibility of microsomal enzymes in response to stimulation by phenobarbitone and beta-naphthoflavone in the diet
    • Mc Danell RE, Mc Lean AEM (1974) Differences between small and large intestine and liver in the inducibility of microsomal enzymes in response to stimulation by phenobarbitone and beta-naphthoflavone in the diet. Biochem Pharmacol 33: 1977-1980
    • (1974) Biochem Pharmacol , vol.33 , pp. 1977-1980
    • Mc Danell, R.E.1    Mc Lean, A.E.M.2
  • 23
    • 0022510324 scopus 로고
    • Epoxide hydrolysis in the cytosol of rat liver, kidney and testis
    • Moody DE, Silva MH, Hammock BD (1986) Epoxide hydrolysis in the cytosol of rat liver, kidney and testis. Biochem Pharmacol 35: 2073-2080.
    • (1986) Biochem Pharmacol , vol.35 , pp. 2073-2080
    • Moody, D.E.1    Silva, M.H.2    Hammock, B.D.3
  • 24
    • 0011883638 scopus 로고
    • Effect of fasting on the liver toxicity of a single oral dose of sodium valproate, 4-en valproic acid, pentenoic acid, pentanoic acid and 2-n-pentylaminoacetamide in the rat
    • Abstr
    • Ndangiza A, Masson M, Palate B, Roba J (1992) Effect of fasting on the liver toxicity of a single oral dose of sodium valproate, 4-en valproic acid, pentenoic acid, pentanoic acid and 2-n-pentylaminoacetamide in the rat. Toxicol Lett [Suppl 1992]: 326 [Abstr]
    • (1992) Toxicol Lett , Issue.1992 SUPPL. , pp. 326
    • Ndangiza, A.1    Masson, M.2    Palate, B.3    Roba, J.4
  • 25
    • 8244256222 scopus 로고
    • Phase II study to evaluate the efficacy and safety of milacemide (CP 1552 S) in the treatment of complex partial seizures in adult patients
    • Abstr
    • Norton LC, Laxer KD, Schomer D, Osborn P (1986) Phase II study to evaluate the efficacy and safety of milacemide (CP 1552 S) in the treatment of complex partial seizures in adult patients. Epilepsia 27: 648 [Abstr]
    • (1986) Epilepsia , vol.27 , pp. 648
    • Norton, L.C.1    Laxer, K.D.2    Schomer, D.3    Osborn, P.4
  • 26
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 239: 2370-2378
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 27
    • 0028178695 scopus 로고
    • Fasting for 24 h reveals liver microsteatosis after continuous i.v. infusion of milacemide in the rat
    • Rakotoamboa JL, Masson M, Palate B, Carleer J, Roba J (1994) Fasting for 24 h reveals liver microsteatosis after continuous i.v. infusion of milacemide in the rat. Arch Toxicol 68: 266-271
    • (1994) Arch Toxicol , vol.68 , pp. 266-271
    • Rakotoamboa, J.L.1    Masson, M.2    Palate, B.3    Carleer, J.4    Roba, J.5
  • 30
    • 0021929330 scopus 로고
    • Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes
    • Rogiers V, Vandenberghe Y, Vercruysse A (1985) Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes. Xenobiotica 15: 759-765
    • (1985) Xenobiotica , vol.15 , pp. 759-765
    • Rogiers, V.1    Vandenberghe, Y.2    Vercruysse, A.3
  • 31
    • 0022886583 scopus 로고
    • Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes
    • Rogiers V, Adriaenssens L, Vandenberghe Y, Gepts E, Callaerts A, Vercruysse A (1986) Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes. Xenobiotica 16: 817-826
    • (1986) Xenobiotica , vol.16 , pp. 817-826
    • Rogiers, V.1    Adriaenssens, L.2    Vandenberghe, Y.3    Gepts, E.4    Callaerts, A.5    Vercruysse, A.6
  • 32
    • 0023924121 scopus 로고
    • The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes
    • Rogiers V, Vandenberghe Y, Callaerts A, Sonck W, Maes V, Vercruysse A (1988) The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes. Xenobiotica 18: 665-673
    • (1988) Xenobiotica , vol.18 , pp. 665-673
    • Rogiers, V.1    Vandenberghe, Y.2    Callaerts, A.3    Sonck, W.4    Maes, V.5    Vercruysse, A.6
  • 33
    • 0025184995 scopus 로고
    • Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes
    • Rogiers V, Vandenberghe Y, Callaerts A, Sonck W, Vercruysse A (1990) Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes. Toxic In Vitro 4(45): 439-442
    • (1990) Toxic in Vitro , vol.4 , Issue.45 , pp. 439-442
    • Rogiers, V.1    Vandenberghe, Y.2    Callaerts, A.3    Sonck, W.4    Vercruysse, A.5
  • 34
    • 0027483520 scopus 로고
    • Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid
    • Semba J, Curzon G, Patsalos PN (1993) Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid. Br J Pharmacol 108: 1117-1124
    • (1993) Br J Pharmacol , vol.108 , pp. 1117-1124
    • Semba, J.1    Curzon, G.2    Patsalos, P.N.3
  • 36
    • 8244254620 scopus 로고
    • Initial results with milacemide in epileptic patients
    • Waltregny A, Onkelinx C (1993) Initial results with milacemide in epileptic patients. Neurol Psychiatr 6: 158-173
    • (1993) Neurol Psychiatr , vol.6 , pp. 158-173
    • Waltregny, A.1    Onkelinx, C.2
  • 37
    • 0014546946 scopus 로고
    • Correlated morphometric and biochemical studies on the liver cell. A morphometric model, stereologic methods and normal morphometric data for rat liver
    • Weibel E, Stäubli W, Gnagi RH, Hess FA (1969) Correlated morphometric and biochemical studies on the liver cell. A morphometric model, stereologic methods and normal morphometric data for rat liver. J Cell Biol 42: 68-91
    • (1969) J Cell Biol , vol.42 , pp. 68-91
    • Weibel, E.1    Stäubli, W.2    Gnagi, R.H.3    Hess, F.A.4
  • 38
    • 0004812345 scopus 로고
    • Perfusion fixation of human and rat liver tissue for light and electron microscopy: A review and assessment of existing methods with special emphasis on sinusoidal cells and microcirculation
    • O'Hare AMF (ed) SEM, Chicago
    • Wisse E, De Wilde A, De Zanger R (1984) Perfusion fixation of human and rat liver tissue for light and electron microscopy: a review and assessment of existing methods with special emphasis on sinusoidal cells and microcirculation. In: O'Hare AMF (ed) Science of biological specimen preparation. SEM, Chicago, pp 31-38
    • (1984) Science of Biological Specimen Preparation , pp. 31-38
    • Wisse, E.1    De Wilde, A.2    De Zanger, R.3
  • 39
    • 0023258627 scopus 로고
    • Rat liver cytochrome P-450 isoenzymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes
    • Wolff T, Guengerich P (1987) Rat liver cytochrome P-450 isoenzymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes. Biochem Pharmacol 36: 2581-2588
    • (1987) Biochem Pharmacol , vol.36 , pp. 2581-2588
    • Wolff, T.1    Guengerich, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.