Current status of inhaled nitric oxide therapy in the perinatal period

Early Human Development

Volumn 47, Issue 3, 1997, Pages 247-262

  Mupanemunda, Richard H ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Inhalation; Nitric oxide; Perinatal period; Review; Therapy

Indexed keywords

NITRIC OXIDE;

HUMAN; HYPOXEMIA; INHALATIONAL DRUG ADMINISTRATION; LUNG BLOOD FLOW; NEWBORN; PATHOPHYSIOLOGY; PERINATAL PERIOD; PULMONARY HYPERTENSION; REVIEW; VASODILATATION; VASOSPASM;

EID: 0030985624     PISSN: 03783782     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-3782(96)01797-5     Document Type: Article

References (72)

1. Walker, A.M., Ritchie. B.C., Adamson, T.M. and Maloney, J.E. (1988): Effect of changing lung volume on the pulmonary circulation of fetal lambs. J. Appl. Physiol., 64, 61-67.
2. Furchgott, R.F. and Zawadski, J.V. (1980): The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
3. Terragno, N.A. and Terragno, A. (1979): Prostaglandin metabolism in fetal and maternal vasculature. Fed. Proc., 38, 75-77.
4. Abman, S.H. and Stenmark, K.R. (1992): Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs. Am. J. Physiol., 262, L214-L222.
5. Velvis, H., Moore, P. and Heyman, M.A. (1991): Prostaglandin inhibition prevents the fall in pulmonary vascular resistance as a result of rhythmic distension of the lungs in fetal lambs. Pediatr. Res., 30, 62-68.
6. Busse, R., Mulsch, A., Fleming, I. et al. (1993): Mechanisms of nitric oxide release from the vascular endothelium. Circulation, 87, V-18.
7. Ignarro, L.J. (1989): Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ. Res., 65, 1-21.
8. Moncada, S., Palmer, R.M. and Higgs, E.A. (1991): Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142.
9. Abman, S.H., Chatfield, B.A., Hall, S.L. and McMurtry, I.F. (1990): Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am. J. Physiol., 259, 1921-1927.
10. Kinsella, J.P., McQueston, J.A., Rosenberg, A.A. and Abman, S.H. (1992): Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation. Am. J. Physiol., 263, H875-H880.
11. Tiktinsky, M.H. and Morin III, F.C. (1993): Increasing oxygen tension dilates fetal pulmonary circulation via endothelium-derived relaxing factor. Am. J. Physiol., 265, H376-H380.
12. Shaul, P.W., Farrar, M.A. and Zellers, T.M. (1992): Oxygen modulates endothelium-derived relaxing factor production in fetal pulmonary arteries. Am. J. Physiol., 262, H355-H364.
13. [13[ Shaul, P.W., Wells, L.B. and Horning, K.M. (1993): Acute and prolonged hypoxia attenuates endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J. Cardiovasc. Pharmacol., 22, 819-827.
14. Yanagisawa, M., Kurihara, H., Kimura, S. et al. (1988): A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332, 411-415.
15. Janakidevi, K., Fisher. M.A., Del-Vecchio, P.J., Tiruppathi. C., Figge, J. and Malik, A.B. (1992): Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Am. J. Physiol., 263, C1295-C1301.
16. Kourembanas, S., McQuillan, L.P., Leung, O. and Faller, D.V. (1993): Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under normoxia and hypoxia. J. Clin. Invest., 92, 99-104.
17. Yokokawa, K., Kohno, M., Yasunari, K. et al. (1991): Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells. Hypertension, 18, 304-315.
18. Walsh-Sukys, M.C. (1993): Persistent pulmonary hypertension of the newborn. The black box revisited. Clin. Perinatol., 20, 127-143.
19. Murphy, J.D., Vawter, G.F. and Reid, L.M. (1984): Pulmonary vascular disease in fatal meconium aspiration. J. Pediatr., 104, 758-762.
20. Kourembanas, S. (1992): Hypoxic responses of the neonatal endothelium. Semin. Perinatol., 16, 140-146.
21. Kourembanas, S., Marsden, P., McQuillan, L. and Faller D. (1991): Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J. Clin. Invest., 88, 1054-1057.
22. Giaid, A., Yanagisawa, M., Lagleben, D. et al. (1993): Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med., 328, 1732-1739.
23. Gard, U.C. and Hassid, A. (1989): Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest., 83, 1774-1777.
24. Ogawa, S., Gerlach, H., Esposito, C., Pasagian-Macaulay, A., Brett, J. and Stern, D. (1990): Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. J. Clin. Invest., 85, 1090-1098.
25. Hill, D., Strain, S., Elstors, S., Swenne, I. and Milner, R. (1986): Bifunctional action of transforming growth factor-beta mDNA synthesis in early passage human fetal fibroblast. J. Cell Physiol., 128, 322-328.
26. Stenmark, K., Mecham, R., Durmowica, A. and Parks, W. (1994): Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal pulmonary hypertension. J. Clin. Invest., 93, 1234-1242.
27. Dobyns, E.L., Westcott, J.Y., Kennaugh, J.M. et al. (1994): Eicosanoids decrease in newborns with persistent pulmonary hypertension successfully treated with extracorporeal membrane oxygenation. Am. J. Respir. Crit. Care Med., 149, 873-880.
28. McQueston, J.A., Kinsella, J.P., Ivy, D.D., McMurtry, I.E. and Abman, S.H. (1995): Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am. J. Physiol., 268, H288-H294.
29. Steinhorn, R., Russell, J. and Morin, F. (1995): Disruption of cyclic GMP production in pulmonary arteries isolated from fetal lambs with persistent pulmonary hypertension. Am. J. Physiol., 268, H1483-H1489.
30. Vosatka, R.J., Kashyap, S. and Trifiletti, R.R. (1994): Arginine deficiency accompanies persistent pulmonary hypertension of the newborn. Biol. Neonate, 66, 65-70.
31. Dollberg, S., Warner, B.W. and Myatt, L. (1995): Urinary nitrite and nitrate concentrations in patients with idiopathic persistent pulmonary hypertension of the newborn and effect of extracorporeal membrane oxygenation. Pediatr. Res., 37, 31-34.
32. Roberts, J.D., Polaner, D.M., Lang, P. and Zapol, W.M. (1992): Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet, 340, 818-819.
33. |33] Kinsella, J.P., Neish, S.R., Ivy, D.D., Shaffer, E. and Abman, S.H. (1993): Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. J. Pediatr., 123, 103-108.
34. |34] Storme, L., Francoise, M., Tahiri, C. and Zupan, V. (1994): Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Pediatr. Res., 35, 60A.
35. Finer, N.N., Etches, P.C., Kamstra, B., Tiemey, A.J., Peliowski, A. and Ryan, C.A. (1994): Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose reponse. J. Pediatr., 124, 302-308.
36. Karamanoukian, H., Glick, P., Wilcox, D., Rossman, J., Holm, B. and Morin, F. (1995): Pathophysiology of congenital diaphragmatic hernia (CDH). VIII. Inhaled nitric oxide (NO) requires exogenous surfactant therapy in the lamb model of congenital diaphragmatic hernia. J. Pediatr. Surg., 30, 1-4.
37. Clarke, W.R., Uezono, S., Chambers, A. and Doepfner, P. (1994): The type III phosphodiesterase inhibitor milrinone and type V PDE inhibitor dipyridamole individually and synergistically reduce elevated pulmonary vascular resistance. Pulm. Pharmacol., 7, 81-89.
38. Walther, F.J., Benders, M.J. and Leighton, J.O. (1992): Persistent pulmonary hypertension in premature neontes with severe respiratory distress syndrome, Pediatrics. 90, 899-904.
39. Kääpä, P., Kero, P. and Saraste, M. (1992): Synthetic surfactant replacement therapy decreases estimated pulmonary artery pressure in RDS. Arch. Dis. Child., 146, 961-964.
40. Hamvas, A., Devine, T. and Cole, F.S. (1993): Surfactant therapy failure identifies infants at risk for pulmonary mortality. Am. J. Dis. Child., 147, 665-668.
41. Brus, F., van Oeveren, W., Okken, A. and Bambang Oetomo, S. (1995): Number and activation of neutrophils and platelets are associated with severity of idiopathic respiratory distress syndrome. Pediatr. Res., 38, 427A.
42. Kinsella, J.P., Ivy, D.D. and Abman, S.H. (1994): Inhaled nitric oxide lowers pulmonary vascular resistance and improves gas exchange in severe experimental hyaline membrane disease. Pediatr. Res., 36, 402-408.
43. Mupanemunda, R.H. (1995): Dose-response curves in mild and severe RDS. Pediatr. Res., 38, 446A.
44. Abman, S.H. and Groothius, J.R. (1994): Pathophysiology and treatment of bronchopulmonary dysplasia. Pediatr. Clin. North Am., 41, 277-315.
45. Giaid, A. and Saleh, D. (1995): Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med., 333, 214-221.
46. Kojima, T., Isozaki-Fikuda, Y., Takedatsu, M. et al. (1992): Plasma endothelin-1 like immunoreactivity levels in neonates. Eur. J. Pediatr., 151, 913-915.
47. Kouyoumdjian, C., Adnot, S., Levame, M., Eddahibi, S., Bousbaa, H. and Raffestin, B. (1994): Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J. Clin. Invest., 94, 578-584.
48. Miyauchi, T., Yorikane, R., Sakai, S. et al. (1993): Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with menocrataline-induced pulmonary hypertension. Circ. Res., 73, 887-897.
49. Mupanemunda, R. and Silverman, M. (1994): Low-dose inhaled nitric oxide in infants with bronchopulmonary dysplasia. Pediatr. Res., 36, 31A.
50. Abman, S.H., Griebel, J.L., Parker, D.K., Schmidt, J.M. and Kinsella, J.P. (1994): Acute effects of inhaled nitric oxide in children with severe hypoxaemic respiratory failure. J. Pediatr., 124, 881-888.
51. Eddahibi, S., Adnot, S., Carville, C., Blouquit, Y. and Raffestin, B. (1992): L-Arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats. Am. J. Physiol., 2, 263. L194-L200.
52. Shankaran, S., Farooki, Z.Q. and Desai, R. (1982): β-Hemolytic streptococcal infection appearing as persistent fetal circulation. Am. J. Dis. Child., 136, 725-727.
53. Lonnqvst, P.A., Winberg, P., Lundell, B., Sellden, H. and Olsson, G.L. (1994): Inhaled nitric oxide in neonates and children with pulmonary hypertension. Acta Paediatr., 83, 1132-1136.
54. Frostell, C., Fratacci. M-D., Wain, J.C., Jones, R. and Zapol, W.M. (1991): Inhaled nitric oxide: a selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation, 83. 2038-2047.
55. Gaston, B., Drazen, J.M, Loscalzo, J. and Stamler, J.S. (1994): The biology of nitrogen oxides in the airways. Am. J. Respir. Crit. Care Med., 149, 538-551.
56. Frampton, M.W., Morrow, P.E., Cox, C., Gibb, F.R., Speers, D.M. and Utell, M.J. (1991): Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am. Rev. Respir. Dis., 143, 522-527.
57. Hogman, M., Frostell, C., Arnberg, H. and Hedenstierna, G. (1993): Bleeding time prolongation and NO inhalation. Lancet. 341, 1664-1665.
58. Hogman, M., Frostell, C., Arnberg, H., Sandhagen, B. and Hedenstiema, G. (1994): Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol. Scand., 151, 125-129.
59. Ahluwalia, J., Kelsall, A., Raine, J. et al. (1994): Nitric oxide improves oxygenation in neonates with respiratory distress syndrome and pulmonary hypertension. Pediatr. Res., 36. 3A.
60. Wennmalm, A., Benthin, G. and Peterson, A.S. (1992): Dependence of the metabolism of nitric oxide in healthy human whole blood on the oxygenation of its red cell haemoglobin. Br. J. Pharmacol., 106. 507-844.
61. Kross, B.C., Amadu, A.D. and Fuortes, L.J. (1992): Methemoglobinemia: nitrate toxicity in rural America. Am. Fam. Physician, 45, 183-185.
62. Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A. (1990): Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc. Nat. Acad. Sci. USA, 87, 1620-1624.
63. Haddag, I.Y., Ischiropoulos, H., Holm, B.A., Beckman, J.S., Baker, J.R. and Matalon S. (1993): Mechanisms of peroxynitrite-induced injury to pulmonary surfactants. Am. J. Physiol., 265, L555-L564.
64. Mupanemunda, R.H. and Wigglesworth, J. (1994): Lung histopathology in neonates receiving low-dose inhaled nitric oxide. Pediatr. Res., 36, 30A.
65. Turbow, R., Waffarn, F., Mallman, M. et al. (1994): Inflammatory responses and suppressed macrophage function following inhaled nitric oxide. Pediatr. Res., 35, 356A.
66. Wink, D.A., Kasprzak, K.S., Maragos, C.M. et al. (1991): DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science. 254, 1001-1003.
67. Stamler, J.S., Simon, D.I., Osborne, J.A. et al. (1992): S-Nitrosylation of proteins with NO: synthesis and characterization of biologicallly active compounds. Proc. Natl. Acad. Sci. USA, 89, 444-448.
68. Kavanagh, B.P. Mouchawar, A., Goldsmith, J. and Pearl, R.G. (1994): Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant induced acute lung injury. J. Appl. Physiol., 76, 1324-1329.
69. Steinhorn, R.H., Thusu, K.G., Russell, J.A. et al. (1994): The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide in newborn lambs with persistent pulmonary hypertension. Pediatr. Res., 35, 89A.
70. Leach, C., Fuhrman, B., Morin, F. and Rath, M. (1993): Perfluorocarbon-associated gas exchange (PAGE) in respiratory distress syndrome. Crit. Care Med., 21, 1270-1278.
71. Laech, C.L., Holm, B., Morin III, F.C. et al. (1995): Partial liquid ventilation in respiratory distress syndrome: efficacy and compatibility with exogenous surfactant. J. Pediatr., 126, 412-420.
72. Freden, F., Wei, S.Z., Berglund, J.E., Frostell, C. and Hedenstierna, G. (1995): Nitric oxide modulation of pulmonary blood flow distribution in lobar hypoxia. Anesthesiology. 82, 1216-1225.