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Volumn 25, Issue 3, 1997, Pages 287-295

Inhibition of metoprolol metabolism by amino acids in perfused rat livers: Insights into the food effect?

Author keywords

[No Author keywords available]

Indexed keywords

METOPROLOL; NADOLOL;

EID: 0030985586     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (42)
  • 1
    • 0023787761 scopus 로고
    • Influence of food on the presystemic metabolism of drugs
    • A. Melander, D. Lalka, and A. McLean: Influence of food on the presystemic metabolism of drugs. Pharmacol. Ther. 38, 253-267 (1988).
    • (1988) Pharmacol. Ther. , vol.38 , pp. 253-267
    • Melander, A.1    Lalka, D.2    McLean, A.3
  • 2
    • 0028835307 scopus 로고
    • Contribution of the small intestine to the first-pass uptake and systemic clearance of propranolol in rabbits
    • P. Du Souich, H. Maurice, and L. Heroux: Contribution of the small intestine to the first-pass uptake and systemic clearance of propranolol in rabbits. Drug. Metab. Dispos. 23, 279-284 (1995).
    • (1995) Drug. Metab. Dispos. , vol.23 , pp. 279-284
    • Du Souich, P.1    Maurice, H.2    Heroux, L.3
  • 3
    • 0018191046 scopus 로고
    • Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism
    • A. J. McLean, P. J. McNamara, P. duSouich, M. Gibaldi, and D. Lalka: Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism. Clin. Pharmacol. Ther. 24, 5-10 (1978).
    • (1978) Clin. Pharmacol. Ther. , vol.24 , pp. 5-10
    • McLean, A.J.1    McNamara, P.J.2    Dusouich, P.3    Gibaldi, M.4    Lalka, D.5
  • 5
    • 0024075932 scopus 로고
    • Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: Simulation of the food effect
    • M. W. Modi, J. M. Hassett, and D. Lalka: Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect. Clin. Pharmacol. Ther. 44, 268-274 (1988).
    • (1988) Clin. Pharmacol. Ther. , vol.44 , pp. 268-274
    • Modi, M.W.1    Hassett, J.M.2    Lalka, D.3
  • 6
    • 0020675374 scopus 로고
    • Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding
    • J. Feely, J. Nadeau, and A. J. J. Wood: Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding. Br. J. Clin. Pharmacol. 15, 383-385 (1983).
    • (1983) Br. J. Clin. Pharmacol. , vol.15 , pp. 383-385
    • Feely, J.1    Nadeau, J.2    Wood, A.J.J.3
  • 7
    • 0022447519 scopus 로고
    • Concomitant food intake can increase the bioavailability of propranolol by transient inhibition of its presystemic primary conjugation
    • H. Liedholm and A. Melander: Concomitant food intake can increase the bioavailability of propranolol by transient inhibition of its presystemic primary conjugation. Clin. Pharmacol. Ther. 40, 29-36 (1986).
    • (1986) Clin. Pharmacol. Ther. , vol.40 , pp. 29-36
    • Liedholm, H.1    Melander, A.2
  • 9
    • 0025337308 scopus 로고
    • Mechanisms and variations in the food effect on propranolol bioavailability
    • H. Liedholm, B. E. Wahlin, and A. Melander: Mechanisms and variations in the food effect on propranolol bioavailability. Eur. J. Clin. Pharmacol. 38, 469-475 (1990).
    • (1990) Eur. J. Clin. Pharmacol. , vol.38 , pp. 469-475
    • Liedholm, H.1    Wahlin, B.E.2    Melander, A.3
  • 10
    • 0025321194 scopus 로고
    • A computer simulation of the food effect: Transient changes in hepatic blood flow and Michaelis-Menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol
    • H. A. Semple, Y. K. Tam, and R. T. Coutts: A computer simulation of the food effect: transient changes in hepatic blood flow and Michaelis-Menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol. Biopharm. Drug Dispos. 11, 61-76 (1990).
    • (1990) Biopharm. Drug Dispos. , vol.11 , pp. 61-76
    • Semple, H.A.1    Tam, Y.K.2    Coutts, R.T.3
  • 11
    • 0029156446 scopus 로고
    • Interaction between propranolol and amino acids in the single-pass isolated, perfused rat liver
    • H. A. Semple and F. Xia: Interaction between propranolol and amino acids in the single-pass isolated, perfused rat liver. Drug Metab. Dispos. 24, 794-798 (1995).
    • (1995) Drug Metab. Dispos. , vol.24 , pp. 794-798
    • Semple, H.A.1    Xia, F.2
  • 12
    • 0028020096 scopus 로고
    • Propranolol disposition in the single-pass isolated, perfused rat liver in the presence and absence of insulin and glucagon
    • H. A. Semple and F. Xia: Propranolol disposition in the single-pass isolated, perfused rat liver in the presence and absence of insulin and glucagon. Drug Metab. Dispos. 22, 822-826 (1994).
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 822-826
    • Semple, H.A.1    Xia, F.2
  • 13
    • 0002841050 scopus 로고
    • Technique of isolated rat liver perfusion
    • I. Bartosek, A. Guaitani, and L. L. Miller, eds., Raven Press, New York
    • L. L. Miller: Technique of isolated rat liver perfusion. In "Isolated Liver Perfusion and Its Applications" (I. Bartosek, A. Guaitani, and L. L. Miller, eds.), pp. 11-52. Raven Press, New York, 1973.
    • (1973) Isolated Liver Perfusion and Its Applications , pp. 11-52
    • Miller, L.L.1
  • 14
    • 0001727761 scopus 로고
    • The role of the liver in regulation of amino acid and protein metabolism
    • H. N. Munro, eds., Academic Press, New York
    • D. H. Elwyn: The role of the liver in regulation of amino acid and protein metabolism. In "Mammalian Protein Metabolism" (H. N. Munro, eds.), pp. 523-557. Academic Press, New York, 1970.
    • (1970) Mammalian Protein Metabolism , pp. 523-557
    • Elwyn, D.H.1
  • 17
    • 0017603437 scopus 로고
    • Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzyme activity on hepatic drug clearance
    • K. S. Pang and M. Rowland: Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzyme activity on hepatic drug clearance. J. Pharmacokinet. Biopharm. 5, 625-653 (1977).
    • (1977) J. Pharmacokinet. Biopharm. , vol.5 , pp. 625-653
    • Pang, K.S.1    Rowland, M.2
  • 20
    • 0023221313 scopus 로고
    • Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection
    • K. Balmér, Y. Zhang, Lagerström, and B. E. Persson: Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection. J. Chromatogr. 417, 357-365 (1987).
    • (1987) J. Chromatogr. , vol.417 , pp. 357-365
    • Balmér, K.1    Zhang, Y.2    Lagerström3    Persson, B.E.4
  • 21
    • 0021245444 scopus 로고
    • Determination of two metoprolol metabolites in human urine by high performance liquid chromatography
    • J. Godbillon and M. Duval: Determination of two metoprolol metabolites in human urine by high performance liquid chromatography. J. Chromatogr. 309, 198-202 (1984).
    • (1984) J. Chromatogr. , vol.309 , pp. 198-202
    • Godbillon, J.1    Duval, M.2
  • 22
    • 0021933667 scopus 로고
    • Quantitative analysis of metoprolol and three of its metabolites in urine and liver microsomes by high-performance liquid chromatography
    • M. S. Lennard: Quantitative analysis of metoprolol and three of its metabolites in urine and liver microsomes by high-performance liquid chromatography. J. Chromatogr. 342, 199-205 (1985).
    • (1985) J. Chromatogr. , vol.342 , pp. 199-205
    • Lennard, M.S.1
  • 24
    • 0022513905 scopus 로고
    • Metoprolol oxidation by rat liver microsomes: Inhibition by debrisoquine and other drugs
    • M. S. Lennard, H. K. Crewe, G. T. Tucker, and H. F. Woods: Metoprolol oxidation by rat liver microsomes: inhibition by debrisoquine and other drugs. Biochem. Pharmacol. 35, 2757-2761 (1986).
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 2757-2761
    • Lennard, M.S.1    Crewe, H.K.2    Tucker, G.T.3    Woods, H.F.4
  • 25
  • 27
    • 0028342648 scopus 로고
    • Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
    • J. B. Houston: Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol. 47, 1469-1479 (1994).
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1469-1479
    • Houston, J.B.1
  • 28
    • 0023788246 scopus 로고
    • Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes
    • S. V. Otton, H. K. Crewe, M. S. Lennard, G. T. Tucker, and H. F. Woods: Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. J. Pharmacol. Exp. Ther. 247, 2427 (1988).
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 2427
    • Otton, S.V.1    Crewe, H.K.2    Lennard, M.S.3    Tucker, G.T.4    Woods, H.F.5
  • 29
    • 0027366792 scopus 로고
    • Individual variation in first-pass metabolism
    • Y. K. Tam: Individual variation in first-pass metabolism. Clin. Pharmacokinet. 25, 300-328 (1993).
    • (1993) Clin. Pharmacokinet. , vol.25 , pp. 300-328
    • Tam, Y.K.1
  • 30
    • 0027514208 scopus 로고
    • Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes
    • M. Kim, D. D. Shen, A. C. Eddy, W. L. Nelson, and L. K. Roskos: Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes. Drug Metab. Dispos. 21, 309-317 (1993).
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 309-317
    • Kim, M.1    Shen, D.D.2    Eddy, A.C.3    Nelson, W.L.4    Roskos, L.K.5
  • 32
    • 0002758464 scopus 로고
    • Biotransformation and zonal toxicity
    • R. G. Thurman, F. C. Kauffman, and K. Jungermann, eds., Plenum, New York
    • R. G. Thurman, F. C. Kauffman, and J. Baron: Biotransformation and zonal toxicity. In "Regulation of Hepatic Metabolism" (R. G. Thurman, F. C. Kauffman, and K. Jungermann, eds.), pp. 321-382. Plenum, New York, 1986.
    • (1986) Regulation of Hepatic Metabolism , pp. 321-382
    • Thurman, R.G.1    Kauffman, F.C.2    Baron, J.3
  • 33
    • 0000645264 scopus 로고
    • Lobular oxygen gradients: Possible role in alcohol-induced hepatotoxicity
    • R. G. Thurman, F. C. Kauffman, and K. Jungermann, eds., Plenum, New York
    • R. G. Thurman, S. Ji, and J. J. Lemasters: Lobular oxygen gradients: possible role in alcohol-induced hepatotoxicity. In "Regulation of Hepatic Metabolism" (R. G. Thurman, F. C. Kauffman, and K. Jungermann, eds.), pp. 293-320. Plenum, New York, 1986.
    • (1986) Regulation of Hepatic Metabolism , pp. 293-320
    • Thurman, R.G.1    Ji, S.2    Lemasters, J.J.3
  • 34
    • 0002867561 scopus 로고
    • Energy metabolism
    • I. M. Arias, ed., Raven Press Ltd., New York
    • S. Seifter and S. Englard: Energy metabolism. In "The Liver: Biology and Pathobiology" (I. M. Arias, ed.), pp. 323-364. Raven Press Ltd., New York, 1994.
    • (1994) The Liver: Biology and Pathobiology , pp. 323-364
    • Seifter, S.1    Englard, S.2
  • 35
    • 0019424955 scopus 로고
    • Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats
    • K. S. Pang and J. A. Terrell: Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats. J. Pharmacol. Exp. Ther. 216, 339-346 (1981).
    • (1981) J. Pharmacol. Exp. Ther. , vol.216 , pp. 339-346
    • Pang, K.S.1    Terrell, J.A.2
  • 36
    • 0027458624 scopus 로고
    • The effect of hypoxia on propranolol clearance during antegrade and retrograde flow in the isolated perfused rat liver preparation
    • S. L. Elliott, D. J. Morgan, P. W. Angus, H. Ghabrial, R. G. Watson, and R. A. Smallwood: The effect of hypoxia on propranolol clearance during antegrade and retrograde flow in the isolated perfused rat liver preparation. Biochem. Pharmacol. 45, 573-578 (1993).
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 573-578
    • Elliott, S.L.1    Morgan, D.J.2    Angus, P.W.3    Ghabrial, H.4    Watson, R.G.5    Smallwood, R.A.6
  • 37
    • 0003060170 scopus 로고
    • Liver perfusion studies in drug metabolism and drug toxicity
    • J. R. Mitchell and M. G. Horning, eds., Raven Press, New York
    • K. S. Pang: Liver perfusion studies in drug metabolism and drug toxicity. In "Drug Metabolism and Drug Toxicity" (J. R. Mitchell and M. G. Horning, eds.), pp. 331-352. Raven Press, New York, 1984.
    • (1984) Drug Metabolism and Drug Toxicity , pp. 331-352
    • Pang, K.S.1
  • 38
    • 0021288257 scopus 로고
    • Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver
    • D. B. Jones, G. W. Mihaly, R. A. Smallwood, L. K. Webster, D. J. Morgan, and N. P. Madsen: Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver. Hepatology 4, 461-466 (1984).
    • (1984) Hepatology , vol.4 , pp. 461-466
    • Jones, D.B.1    Mihaly, G.W.2    Smallwood, R.A.3    Webster, L.K.4    Morgan, D.J.5    Madsen, N.P.6
  • 40
    • 0028315969 scopus 로고
    • Influence of protein ingestion on human splanchnic and whole-body oxygen consumption, blood flow, and blood temperature
    • T. Brundin and J. Wahren: Influence of protein ingestion on human splanchnic and whole-body oxygen consumption, blood flow, and blood temperature. Metabolism 43, 626-632 (1994).
    • (1994) Metabolism , vol.43 , pp. 626-632
    • Brundin, T.1    Wahren, J.2
  • 41
    • 0028228612 scopus 로고
    • Meal induced changes in hepatic and splanchnic circulation: A noninvasive Doppler study in normal humans
    • M. Dauzat, M. Lafortune, H. Patriquin, and G. Pomier Layrargues: Meal induced changes in hepatic and splanchnic circulation: a noninvasive Doppler study in normal humans. Eur. J. Appl. Physiol. 68, 373-380 (1994).
    • (1994) Eur. J. Appl. Physiol. , vol.68 , pp. 373-380
    • Dauzat, M.1    Lafortune, M.2    Patriquin, H.3    Pomier Layrargues, G.4
  • 42
    • 0028805365 scopus 로고
    • Effects of sensory (teasing) exposure to food on oral propranolol bioavailability
    • J. M. Power, D. J. Morgan, and A. J. McLean: Effects of sensory (teasing) exposure to food on oral propranolol bioavailability. Biopharm. Drug Dispos. 16, 579-589 (1995).
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 579-589
    • Power, J.M.1    Morgan, D.J.2    McLean, A.J.3


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