Quartz dust retention in rat lungs under chronic exposure simulated by a multicompartmental model: Further evidence of the key role of the cytotoxicity of quartz particles

Inhalation Toxicology

Volumn 9, Issue 8, 1997, Pages 703-715

  Katsnelson, B A ^a   Konysheva, L K ^a   Privalova, L I ^a   Sharapova, N Y ^a  

^a The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030985467     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583797197953     Document Type: Article

References (13)

1. Beilmann, B., Muhle, H., Creutzenberg, O., Dasenbrock, C., Klipper, R., MacKenzie, J. C., Morrow, P., and Mermelstein R. 1991. Lung clearance and retention of toner, utilizing a tracer technique, during chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17:300-313.
2. Brain, J. D. 1985. Macrophages in the respiratory tract. In Handbook of physiology, eds. A. P. Fishman and A. B. Fisher, Vol. 1, pp. 447-471. Bethesda, MD: American Physiological Society.
3. DiStefano, J. J. III, and Landaw, E. M. 1984. Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations. Am J. Physiol. (Regul. Integrat Comp. Physiol. 15) 246:R651-R664.
4. Katsnelson, B. A., and Privalova, L. I. 1984. Recruitment of phagocytizing cells into respiratory tract as a response to the cytotoxic action of deposited particles. Environ. Health Perspect. 55:313-325.
5. Katsnelson, B. A., Konysheva, L. K., Privalova, L. I., and Morosova, K. I. 1992. Development of a multicompartmental model of the kinetics of quartz dust in the pulmonary region of the lungs during chronic exposure of rats. Br. J. Ind. Med. 49:172-181.
6. Katsnelson, B. A., Privalova, L. I., Sharapova, N. Y., and Kislitsina, N. S. 1993. A contribution to the establishment of a battery of short-term tests for estimating comparative cytotoxicity (an overview). Current Toxicol. 1:63-69.
7. Katsnelson, B. A., Konysheva, L. K., Sharapova, N. Y., and Privalova, L. I. 1994. Prediction of the comparative intensity of pneumoconiotic changes caused by chronic inhalation exposure to dusts of different cytotoxicity by means of a mathematical model. Occup. Environ. Med. 51:173-180.
8. Katsnelson, B. A., Alexeyeva, O. G., Privatova, L. I., and Polzik, E. V. 1995. Pneumoconioses: Pathogenesis and biological prophylaxis (in Russian). Ekaterinburgh: Urals Branch of the Russian Academy of Sciences.
9. Klosterkötter, W., and Einbrodt, H. J. 1966. Retention, penetration and elimination of inhaled dusts. In Inhaled particles and vapours II, pp. 215-227. Oxford: Pergamon Press.
10. Mohr, U., Muhle, H., Koch, W., Dasenbrock, C., Fuhst, R., Bartsch, W., Ernst, H., Takenaka, S., Fahrig, R., Görlitz, B., Bellman, B., Creutzenberg, O., König, H., Heinrich, U., and Schneider, B. 1989. Investigation of the Biological Effects of a Toner Fraction; Final Report of a Chronic Inhalation Study in Rats. Report to the Xerox Corporation by Fraunhofer Institut für Toxikologie und Aerosolforschung; Hannover (unpublished).
11. Morosova, K. I., Katsnelson, B. A., Rotenberg, Y. S., and Belobragina, G. V. 1984. A further experimental study of antisilicotic effect of glutamate. Br. J. Ind. Med. 41:518-525.
12. Muhle, H., Bellman, B., Creutzenberg, O., Dasenbrock, C., Ernst, H., Kilpper, R., MacKenzie, C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. 1991. Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17:280-299.
13. Stöber, W., Morrow, P. E., Koch, W., and Morawietz, G. 1994. Alveolar clearance and retention of inhaled insoluble particles in rats simulated by a model inferring macrophage particle load distributions. J. Aerosol Sci. 25:975-1002.