1,2-benzisothiazolin-3-one (Proxel®): Irritant or allergen? A clinical study and literature review

Contact Dermatitis

Volumn 36, Issue 3, 1997, Pages 131-136

  Chew, A L ^a   Maibach, H I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

(5 chloro) 2 methyl 4 isothiazolin 3 one 2 methyl 4 isothiazolin 3 one; 1,2 benzisothiazolin 3 one; Allergic; Biocide; BIT; Contact dermatitis; Irritant; Isothiazolinone; Kathon CG; MCI MI; Occupational; Patch test; Preservative; Proxel

Indexed keywords

1,2 BENZISOTHIAZOLIN 3 ONE; PRESERVATIVE; PROXEL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PATCH TEST; TOPICAL DRUG ADMINISTRATION;

EID: 0030984614     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1997.tb00394.x     Document Type: Article

References (26)

1. Nielsen H. Occupational exposure to isothiazolinones. A study based on a product register. Contact Dermatitis 1994: 31: 18-21.
2. Freeman S. Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in gum arabic. Contact Dermatitis 1984: 11: 146-149.
3. Pedersen N B. Occupational allergy from 1,2-benzisothiazolin-3-one and other preservatives in plastic emulsions. Contact Dermatitis 1976: 2: 340-342.
4. Andersen K E, Veien N K. Biocide patch tests. Contact Dermatitis 1985: 12: 99-103.
5. Adams R M. Occupational skin disease. New York: Grune & Stratton 1983.
6. Brown R. Concomitant sensitization to additives in a coolant fluid. Contact Dermatitis 1979: 5: 340-341.
7. Slovak A J M. Contact dermatitis due to benzisothiazolone in a works analytical team. Contact Dermatitis 1980: 6: 187-190.
8. Andersen K E, Hamann K. The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients. Fd Chem Toxic 1984: 22(8): 655-660.
9. Alomar A, Conde-Salazar L, Romaguera C. Occupational dermatoses from cutting oils. Contact Dermatitis 1985: 12: 129-138.
10. Cronin E. Contact dermatitis. Edinburgh: Churchill Livingstone, 1980: 209.
11. Sanz-Gallen P, Planas J, Martinez P, Gimenez-Arnau J M. Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in paint manufacture. Contact Dermatitis 1992: 27: 271.
12. Greig D E. Another isothiazolinone source. Contact Dermatitis 1991: 25: 201-202.
13. Alomar A. Contact dermatitis from benzisothiazolone in cutting oils. Contact Dermatitis 1981: 7: 155-156.
14. Fischer T, Maibach H I. Improved, but not perfect, patch testing. American Journal of Contact Dermatitis 1990: 1: 73-90.
15. Marzulli F N, Maibach H I. Dermatotoxicology, 5th edition. Washington DC: Taylor & Francis, 1996: 509-511.
16. Dias M, Lamarao P, Vale T. Occupational contact allergy to 1,2-benzisothiazolin-3-one in the manufacture of air fresheners. Contact Dermatitis 1992: 27: 205.
17. Ezzelerab M, Hansson C, Wallengren J. Occupational allergy caused by 1,2-benzisothiazolin-3-one in water-based paints and glues. Am J Contact Dermatitis 1994: 5: 165-167.
18. Roberts D L, Messenger A G, Summerly R. Occupational dermatitis due to 1,2-benzisothiazolin-3-one in the pottery industry. Contact Dermatitis 1981: 7: 145-147.
19. Botham P A, Hilton J, Evans C D, Lees D, Hall T J. Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay. Contact Dermatitis 1991: 25: 172-177.
20. Hopkins J. Missed opportunities in clinical dermatology - the case of 1,2-benzisothiazolin-3-one. Fd Chem Toxic 1994: 32: 189-191.
21. Damstra R J, van Vloten W A, van Ginkel C J W. Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel®): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon® CG. Contact Dermatitis 1992: 27: 105-109.
22. Collier P J, Ramsey A, Waigh R D, et al. Chemical reactivity of some isothiazolone biocides. J Appl Bacteriol 1990: 69: 578-584.
23. Stejskal V D M, Forsbeck M, Nilsson R. Lymphocyte transformation test for diagnosis of isothiazolinone allergy in man. Journal of Investigative Dermatology 1990: 94: 798-802.
24. Marrakchi S, Maibach H I. What is occupational contact dermatitis? An operational definition. Dermatologic Clinics 1994 Jul: 12(3): 477-484.
25. Imperial Chemical Industries Ltd., Manchester, England (1979) T I Biocides B4.79.
26. Andersen KE, Rycroft RJG, Recommended patch test concentrations for preservatives, biocides and antimicrobials. Contact Dermatitis 1991: 25: 1-18.