Effects of eicosapentaenoic and γ-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats

Critical Care Medicine

Volumn 25, Issue 3, 1997, Pages 523-532

  Mancuso, Peter ^a   Whelan, Jay ^a   DeMichele, Stephen J ^c   Snider, Carolyn C ^b   Guszcza, Julie A ^b   Claycombe, Kate J ^a   Smith, Gary T ^b   Gregory, Timothy J ^c   Karlstad, Michael D ^b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

scintigraphy; acute lung injury; acute respiratory distress syndrome; adult respiratory distress syndrome; arachidonic acid; ARDS; borage oil; dihomo linolenic acid; enteral nutrition; fish oil

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CALCIMYCIN; CORN OIL; DIHOMO GAMMA LINOLENIC ACID; DOCOSAHEXAENOIC ACID; ENDOTOXIN; FATTY ACID; FISH OIL; GAMMA LINOLENIC ACID; ICOSANOID; ICOSAPENTAENOIC ACID; LEUKOTRIENE B4; LEUKOTRIENE B5; PHOSPHOLIPID; PROSTAGLANDIN E2; THROMBOXANE A2; THROMBOXANE B2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BIOSYNTHESIS; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOTOXEMIA; FAT INTAKE; LEUKOCYTE COUNT; LIPID COMPOSITION; LIVER; LUNG ALVEOLUS MACROPHAGE; LUNG BLOOD VESSEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE COUNT;

ANIMALS; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; EICOSAPENTAENOIC ACID; ENDOTOXEMIA; GAMMA-LINOLENIC ACID; LUNG; MACROPHAGES, ALVEOLAR; MALE; RANDOM ALLOCATION; RATS; RATS, INBRED STRAINS; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 0030984371     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199703000-00024     Document Type: Article

References (41)

1. Brigham KL, Meyrick B: Endotoxin and lung injury. Am Rev Respir Dis 1986; 133:913-927
2. Stephenson AH, Lonigro AJ, Hyers TM, et al: Increased concentrations of leukotrienes in bronchoalveolar lavage fluid of patients with ARDS or at risk for ARDS. Am Rev Respir Dis 1988; 138:714-719
3. 4 action on endothelium mediates augmented neutrophil/endothelial adhesion. Proc Natl Acad Sci USA 1984; 81:2191-2193
4. Sharar SR, Winn RK, Harlan JM: Endotoxin-induced interactions of inflammatory cells with the lungs. In: Endotoxin and the Lungs. Brigham KL (Ed). New York, Marcel Dekker, 1994, pp 229-265
5. 4, on canine bronchial smooth muscle. Am J Physiol 1994; 266:L414-L425
6. 4 antagonist, on pulmonary function and mesenteric perfusion in a porcine model of endotoxic shock and ARDS. Circ Shock 1991; 33: 7-16
7. Makhlouf M, Durando M, Cook JA, et al: Role of eicosanoids in endotoxin-induced lung dysfunction. In: Endotoxin and the Lungs. Brigham KL (Ed). New York, Marcel Dekker, 1994, pp 153-169
8. Burton JL: Dietary fatty acids and inflammatory skin disease. Lancet 1989; 7:27-31
9. Tate G, Mandell BF, LaPosata M, et al: Suppression of acute and chronic inflammation by dietary gamma linolenic acid. J Rheumatol 1989; 16: 729-734
10. Teo TC, DeMichele SJ, Selleck KM, et al: Administration of structured lipid composed of MCT and fish oil reduces net protein catabolism in enterally fed burned rats. Ann Surg 1989; 210: 100-107
11. Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991; 54:438-463
12. Tate GA, Mandell BF, Karmali RA, et al: Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Arthritis Rheum 1988; 31:1543-1551
13. Murray MJ, Svingen BA, Holman RT, et al: Effects of a fish oil diet on pigs' cardiopulmonary response to bacteremia. JPEN 1991; 15:152-158
14. Whelan J, Broughton KS, Kinsella JE: The comparative effects of dietary alpha-linolenic acid and fish oil on 4- and 5-series leukotriene formation in vivo. Lipids 1991; 26:119-126
15. Lands WE, LeTellier PR, Rome LH: Inhibition of prostaglandin biosynthesis. Adv Biosci 1972; 9:15-27
16. Lands WEM: Biochemistry and physiology of n-3 fatty acids. FASEB J 1992; 6:2530-2536
17. 3 is formed in vivo in man after dietary eicosapentaenoic acid. Nature 1984; 307:165-168
18. 5 and the double lipoxygenase product. J Biol Chem 1984; 259: 2383-2389
19. Karlstad MD, DeMichele SJ, Leathem WD, et al: Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. Crit Care Med 1993; 21:1740-1749
20. 1 synthesis is altered by dietary gamma-linolenic acid. J Nutr 1992; 122: 1600-1606
21. Chapkin RS, Miller CC, Somers SD, et al: Ability of 15-hydroxyeicosatrienoic acid (15-OH-20:3) to modulate macrophage arachidonic acid metabolism. Biochem Biophys Res Commun 1988; 153:799-804
22. 1 in acute respiratory distress syndrome: A placebo-controlled, randomized, double-blind, multicenter clinical trial. Crit Care Med 1996; 24:10-15
23. 5 in rat basophilic leukemia cells. Eur J Biochem 1981; 120:41-45
24. Whelan J, Broughton KS, Surette ME, et al: Dietary arachidonic and linoleic acids: Comparative effects on tissue lipids. Lipids 1992; 27:85-88
25. Read MA, Meyrick BO: Effects of endotoxin on lung endothelium. In: Endotoxin and the Lung. Brigham KL (Ed). New York, Marcel Dekker, 1994, pp 83-110
26. Kollef MH, Schuster DP: The acute respiratory distress syndrome. N Engl J Med 1995; 332:27-37
27. Askanazi J, Rosenbaum SH, Hyman AI, et al: Respiratory changes induced by the large glucose loads of total parenteral nutrition. JAMA 1980; 243: 1444-1447
28. Skeie B, Askanazi J, Rothkopf MM, et al: Intravenous fat emulsions and lung function: A review. Crit Care Med 1988; 16:183-194
29. Sugerman HJ, Strash AM, Hirsch JI, et al: Sensitivity of scintigraphy for detection of pulmonary capillary albumin leak in canine oleic acid ARDS. J Trauma 1991; 21:520-527
30. Chin JPF, Dart AM: How do fish oils effect vascular function. Clin Exp Pharmacol Physiol 1995; 22:71-81
31. Murray MJ, Kumar M, Gregory TJ, et al: Enterai diets enriched in eicosapentaenoic acid and gamma-linolenic acid attenuate cardiopulmonary dysfunction in a porcine model of acute lung injury. Am J Physiol 1995; 269:H2090-H2099
32. 4. Am J Clin Nutr 1992; 55: 39-45
33. Billiar TR, Bankey PE, Svingen BA, et al: Fatty acid intake and Kupffer cell function: Fish oil alters eicosanoid and monokine production to endotoxin stimulation. Surgery 1988; 104: 343-349
34. Kinsella JE, Broughton KS, Whelan JW: Dietary unsaturated fatty acids: Interactions and possible needs in relation to eicosanoid synthesis. J Nutr Biochem 1990; 1:123-141
35. 4 induces lung injury in the rabbit: Role of neutrophils and effect of indomethacin. J Appl Physiol 1993; 74:2174-2179
36. 4 and pulmonary edema in phorbol ester-induced lung injury in dogs. J Appl Physiol 1992; 73:2493-2498
37. Ball HA, Cook JA, Spicer KM, et al: Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury. J Appl Physiol 1989; 57: 811-816
38. Wisner D, Sturm J, Sutler G, et al: Thromboxane receptor blockade in an animal model of ARDS. Surgery 1988; 104:91-97
39. Svartholm E, Bergqvist D, Hedner U, et al: Arachidonic acid cascade metabolites in porcine E. coli shock. Acta Chir Scand Suppl 1988; 154: 133-139
40. Cook JA, Wise WC, Halushka PV: Elevated thromboxane levels in the rat during endotoxic shock: Protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. J Clin Invest 1980; 65:227-230
41. Santoli D, Phillips PD, Colt TL, et al: Suppression of interleukin 2-dependent human T cell growth in vitro by prostaglandin E and their precursor fatty acids. J Clin Invest 1990; 85: 424-432