Double adenomas with different pathological and hormonal features in the left adrenal gland of a patient with Cushing's syndrome

Clinical Endocrinology

Volumn 46, Issue 2, 1997, Pages 227-234

  Satoh, Fumitoshi ^a   Murakami, Osamu ^a   Takahashi, Kazuhiro ^a   Ueno, Junji ^b   Nishikawa, Tetsuo ^c   Abe, Keishi ^a   Mouri, Toraichi ^a   Sasano, Hironobu ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b EIKEN CHEMICAL CO LTD   (Japan)

^c YOKOHAMA ROSAI HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

ADENOMA; ADRENAL GLAND; ADULT; ARTICLE; CASE REPORT; CELL CULTURE; CUSHING SYNDROME; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; STEROIDOGENESIS;

EID: 0030984251     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.1130930.x     Document Type: Article

References (22)

1. Aiba, M., Kawakami, M., Ito, Y., Fujimoto, Y., Suda, T. & Demura, H. (1992) Bilateral adrenocortical adenomas causing Cushing's syndrome. Archives of Pathology and Laboratory Medicine, 116, 146-150.
2. Barbieri, R.L., Osathanondh, R. & Canick, J.A. (1980) Danazol inhibits human adrenal 21- and 11β-hydroxylation in vitro. Steroids, 35, 251-263.
3. Chappell, A.G. (1963) Cushing's syndrome due to bilateral adrenal adenomata. Proceedings of the Royal Society Medicine, 56, 165-166.
4. Gordon, M.T., Anderson, D.C. & Mitchell, R. (1985) Some characteristics of human adrenal microsomal 21-hydroxylase activity. Journal of Steroid Biochemistry, 23, 67-72.
5. Greiner, J.W., Kramer, R.E. & Jarrell, J. (1976) Mechanism of action of spironolactone on adrenocortical function in guinea pigs. Journal of Pharmacology and Experimental Therapeutics, 198, 709-715.
6. Hoffman, R.M. (1991) Three-dimensional gel-supported native-state histoculture for evaluation of tumor-specific pharmacological activity: principles, practice and possibilities. Journal of Cell Pharmacology, 2, 189-201.
7. Kaneko, H. & Ishigouoka, M. (1990) A case report of Cushing syndrome due to three distinct adenomas of the right adrenal gland (in Japanese). Japanese Journal of Urology, 81, 909-912.
8. Kiyohara, H., Kuroda, M. & Miki T. (1979) A Cushing syndrome with unilateral multiple adrenocortical adenomas (in Japanese). Japanese Journal of Urology, 25, 1307-1313.
9. Lowry, O.H., Rosebrough, N.J. & Farr, A.L. (1951) Protein measurement within the folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
10. Mimou, N., Sakato, S., Nakabayashi, H., Saito, Z., Takeda, R. & Matsubara, F. (1985) Cushing's syndrome associated with bilateral adrenal adenomas. Acta Endocrinologica, 108, 245-254.
11. Nishikawa, T. & Strott, C.A. (1984) Steroid concentrations in the outer and inner zones of the adrenal cortex of guinea pig. Journal of Steroid Biochemistry, 20, 1123-1127.
12. Sasano, H., Imatani, A., Shizawa, S., Suzuki, S. & Nagura, H. (1995a) Cell proliferation and apoptosis in normal and pathologic human adrenal. Modern Pathology, 8, 11-17.
13. Sasano, H., Maehara, I., Ueno, J., Orikasa, S. & Nagura, H. (1996) Leydig cell tumor of the testis - analysis of testosterone production and secretion by three-dimensional histoculture. Endocrine Journal, 43, 73-78.
14. Sasano, H., Miyazaki, S. & Sawais T. (1992) Primary pigmented nodular adrenocortical disease (PPNAD): Immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases. Modern Pathology, 5, 23-29.
15. Sasano, H., Sato, F., Shizawa, S., Nagura, H. & Coughtrie, M.W.H. (1995b) Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. Modern Pathology, 8, 891-896.
16. Sasano, H., Suzuki, T., Nagura, H. & Nishikawa, T. (1993) Steroidogenesis in human adrenocortical carcinoma. Human Pathology, 24, 397-404.
17. Sasano, H., Suzuki, T. & Nagura, H. (1994) ACTH-independent macronodular adrenocortical hyperplasia: Immunohistochemical and insitu hybridization studies of steroidogenic enzymes. Modern Pathology, 7, 215-219.
18. Sasano, N. & Sasano H. (1990) In The Adrenal Cortex in Functional Endocrine Pathology Volume 2 (eds. K. Kovacs & S.L. Asa), pp. 546-584. Blackwell Science, Boston.
19. Vescio, R.A., Redfern, C.H., Nelson, T.J., Ugoretz, S., Stern, P.H. Hoffman, R.M. (1987) In vivo-like drug responses of human tumors growing in three-dimensional gel-supported primary culture. Proceedings of the National Academy of Sciences of the USA, 84, 5029-5033.
20. Weiss, L.M. (1984) Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. American Journal of Surgical Pathology, 8, 163-169.
21. Wick, M.R., Cherwitz, D.L., McGlennen, R.C. & Dhener, L.P. (1986) Adrenocortical carcinoma: An immunohistochemical comparison with renal cell carcinoma. American Journal of Pathology, 122, 343-352.
22. Yoshikawa, K. & Yajima, A. (1977) Cushing syndrome with multiple adrenocortical adenomas (in Japanese). Igakunoayumi, 103, 175-186.