Viridiofungins, novel inhibitors of sphingolipid synthesis

Journal of Antibiotics

Volumn 50, Issue 4, 1997, Pages 339-343

  Mandala, Suzanne M ^a   Thornton, Rosemary A ^a   Frommer, Beth R ^a   Dreikorn, Sarah ^a   Kurtz, Myra B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; SQUALENE SYNTHASE INHIBITOR; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VIRIDIOFUNGIN DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; LIPOGENESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; TRICHODERMA VIRIDE;

EID: 0030983150     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.339     Document Type: Article

References (14)

1. HARRIS, G. H.; E. T. T. JONES, M. S. MEINZ, M. NALLIN-OMSTEAD, G. L. HELMS, G. F. BILLS, D. ZINK & K. E. WILSON: Isolation and structure elucidation of viridiofungins A, B and C. Tet. Lett. 34: 5235-5238, 1993
2. ONISHI, J. C.; J. A. MILLIGAN, A. BASILIO, J. BERGSTROM, J. CUROTTO, L. HUANG, M. MEINZ, M. NALLIN-OMSTEAD, F. PELAEZ, D. REW, M. SALVATORE, J. THOMPSON, F. VICENTE & M. B. KURTZ: Antimicrobial activity of viridiofungins. J. Antibiotics 50: 334-338, 1997
3. HARRIS, G. H. et al.: New viridiofungins from Trichoderma viride. J. Antibiotics, to be submitted
4. VANMIDDLESWORTH, F. M.; R. A. GIACOBBE, M. LOPEZ, G. GARRITY, J. A. BLAND, K., BARTIZAL, R. A. FROMTLING, J. POLISHOOK, M. ZWEERINK, A. M. EDISON, K. WILSON & R. MONAGHAN: Isolation, fermentation, and preliminary biology of sphingofungins A, B, C, and D; A new family of antifungal agents. I. Fermentation, isolation, and biological activity. J. Antibiotics 45: 861-867, 1992
5. ZWEERINK, M. M.; A. M. EDISON, G. B. WELLS, W. PINTO & R. L. LESTER: Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J. Biol. Chem. 267: 25032-25038, 1992
6. HORN, W. S.; J. L. SMITH, G. F. BILLS, S. L. RAGHOOBAR, G. L. HELMS, M. B. KURTZ, J. A. MARRINAN, B. R. FROMMER, R. A. THORNTON & S. M. MANDALA: Sphingofungins E and F: Novel serine palmitoyltransferase inhibitors from Paecilomyces variotii. J. Antibiotics 45: 1692-1696, 1992
7. MIYAKE, Y.; Y, KOZUTSUMI, S. NAKAMURA, T. FUJITA & T. KAWASAKI: Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/Myriocin. Biochem. Biophys. Res. Comm. 211: 396-403, 1995
8. MANDALA, S. M.; B. R. FROMMER, R. A. THORNTON, M. B. KURTZ, N. M. YOUNG, M. A. CABELLO, O. GENILLOUD, J. M. LIESCH, J. L. SMITH & W. S. HORN: Inhibition of serine palmitoyltransferase activity by lipoxamycin. J. Antibiotics 47: 376-379, 1994
9. MANDALA, S. M.; R. A. THORNTON, B. R. FROMMER, J. E. CUROTTO, W. ROZDILSKY, M. B. KURTZ, R. A. GIACOBBE, G. F. BILLS, M. A. CABELLO, I. MARTIN, F. PILAEZ & G. H. HARRIS: The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. J. Antibiotics 48: 349-356, 1995
10. DIGNAM, J. D.; R. M. LEBOVITZ & R. G. ROEDER: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489, 1983
11. KOLESNICK, R. N.: Sphingomyelin and derivatives as cellular signals. Prog. Lipid Res. 30: 1-38, 1991
12. HANNUN, Y. A. & C. M. LINNARDIC: Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta 1154: 223-236, 1993
13. WANG, E.; W. P. NORRED, C. W. BACON, R. T. RILEY & A. H. MERRILL, Jr.: Inhibition of sphingolipid biosynthesis by fumonisins. J. Biol. Chem. 266: 14486-14490, 1991
14. GELDERBLOM, W. C. A.; K. JASKIEWICZ, W. F. O. MARASAS, P. G. THIEL, R. M. HORAK, R. VLEGGAAR & N. P. J. KRIEK: Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 54: 1806-1811, 1988