1,3-Bisalkylcarbonyl- and 3-alkylcarbonyl-5-fluorouracil prodrugs: Syntheses, thermal, and hydrolytic stability

Drug Development and Industrial Pharmacy

Volumn 23, Issue 6, 1997, Pages 517-525

  Beall, H D ^a   Prankerd, R J ^a   Sloan, K B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL DERIVATIVE; PRODRUG;

ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; HYDROLYSIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE; PH; TEMPERATURE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0030982644     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.3109/03639049709149814     Document Type: Article

References (12)

1. H. D. Beall, Bioreversible derivatives of 5-fluorouracil (5-FU): Improving dermal and transdermal delivery with prodrugs, Ph.D. dissertation, University of Florida, Gainesville (December 1991).
2. K. B. Sloan, J. J. Getz, H. D. Beall, and R. J. Prankerd, Int. J. Pharm., 93, 27 (1993).
3. H. D. Beall, R. J. Prankerd, and K. B. Sloan, Int. J. Pharm., 111, 223 (1994).
4. H. D. Beall and K. B. Sloan, Int. J. Pharm., 129, 203 (1996).
5. H. D. Beall, R. J. Prankerd, and K. B. Sloan, Drug Dev. Ind. Pharm., 22, 85 (1996).
6. A. Buur and H. Bundgaard, Int. J. Pharm., 21, 349 (1984).
7. T. Kametani, K. Kigasawa, M. Hiiragi, K. Wakisaka, S. Haga, Y. Nagamatsu, A. Sugi, K. Fukawa, O. Irino, T. Yamamoto, N. Nishimura, A. Taguchi, T. Okada, and M. Nakayama, J. Med. Chem., 23, 1324 (1980).
8. H. D. Beall, R. J. Prankerd, L. J. Todaro, and K. B. Sloan, Pharm. Res., 10, 905 (1993).
9. A. Buur and H. Bundgaard, J. Pharm. Sci., 75, 522 (1986).
10. K. B. Sloan, unpublished work.
11. N. Bodor, K. B. Sloan, Y. Kuo, and T. Higuchi, J. Pharm. Sci., 67, 1045 (1978).
12. S. Ozaki, Y. Ike, H. Mizuno, K. Ishikawa, and H. Mori, Bull. Chem. Soc. Japn., 50, 2406 (1977).