Generation of antibodies to human IL-12 and amphiregulin by immunization of Balb/c mice with diepitope multiple antigen peptides

Journal of Immunological Methods

Volumn 204, Issue 1, 1997, Pages 23-32

  Ahlborg, Niklas ^a   Paulie, Staffan ^a   Braesch Andersen, Sten ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

B cell epitope; monoclonal antibody; multiple antigen peptide; specific antibodies; T cell help

Indexed keywords

AMPHIREGULIN; CYTOKINE ANTIBODY; EPITOPE; INTERLEUKIN 12; MONOCLONAL ANTIBODY; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; FEMALE; HUMAN; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS; EPITOPES, T-LYMPHOCYTE; FEMALE; GLYCOPROTEINS; GROWTH SUBSTANCES; HUMANS; IMMUNIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 0030981868     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(97)00035-5     Document Type: Article

References (33)

1. Agerberth, B., Gunne, H., Odeberg, J., Kogner, P., Boman, H.G., Gudmundsson, G.H., 1995. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc. Natl. Acad. Sci. USA 92, 195.
2. Ahlborg, N., 1995. Synthesis of a diepitope MAP containing two malaria antigen sequences using Fmoc chemistry. J. Immunol. Methods 179, 269.
3. Ahlborg, N., Andersson, R., Perlmann, P., Berzins, K., 1996. Immune responses in congenic mice to multiple antigen peptides based on defined epitopes from the malaria antigen Pf332. Immunology 88, 630.
4. Bellone, M., Karachunski, P.I., Ostlie, N., Lei, S., Conti-Tronconi, B.M., 1994. Preferential pairing of T and B cells for production of antibodies without covalent association of T and B epitopes. Eur. J. Immunol. 24, 799.
5. Briand, J.-P., Barin, C., Van Regenmortel, M.H.V., Muller, S., 1992. Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies. J. Immunol. Methods 156, 255.
6. Briand, J.P., Muller, S., Van Regenmortel, M.H.V., 1985. Synthetic peptides as antigens: Pitfalls of conjugation methods. J. Immunol. Methods 78, 59.
7. Calvo-Calle, J.M., de Oliveira, G.A., Clavijo, P., Maracic, M., Tam, J.P., Lu, Y.-A., Nardin, E.H., Nussenzweig, R.S., Cochrane, A.M., 1993. Immunogenicity of multiple antigen peptides containing B and non-repeat T cell epitopes of the circumsporozoite protein of Plasmodium falciparum. J. Immunol. 150, 1403.
8. Chai, S.K., Clavijo, P., Tam, J.P., Zavala, F., 1992. Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes. J. Immunol. 149, 2385.
9. Das, S.K., Chakraborty, I., Paria, B.C., Wang, X.-N., Plowman, G., Dey, S.K., 1995. Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol. Endocrinol. 9, 691.
10. Esposito, G., Fogolari, F., Viglino, P., Cattarinussi, S., de Magistris, M.T., Chiapinelli, L., Pessi, A., 1993. Conformational study of a short Pertussis toxin T cell epitope incorporated in a multiple antigen peptide template by CD and two-dimensional NMR: Analysis of the structural effects on the activity of synthetic immunogens. Eur. J. Biochem. 217, 171.
11. Francis, M.J., Hastings, G.Z., Syred, A.D., McGinn, B., Brown, F., Rowlands, D.J., 1987. Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants. Nature 300, 168.
12. Gammon, G., Shastri, N., Cogswell, J., Wilbur, S., Sadegh-Nasseri, S., Krzych, U., Miller, A., Sercarz, E., 1987. The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol. Rev. 98, 53.
13. Geerligs, H.J., Weijer, W.J., Bloemhoff, W., Welling, G.W., Welling-Wester, S., 1988. The influence of pH and ionic strength on the coating of peptides of herpes simplex virus type 1 in an enzyme-linked immunosorbent assay. J. Immunol. Methods 106, 239.
14. Houghten, R.A., 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82, 5131.
15. cdc2 kinase. J. Immunol. Methods 156, 163.
16. Katoh, S., Terashima, M., Tomioka, K., Hikida, N., 1996. Use of peptide immunization for porcine insulin of a very high homology with a host protein. J. Immunol. Methods 191, 33.
17. Koho, H., Paulie, S., Ben-Aissa, H., Jonsdottir, I., Hansson, Y., Lundblad, M.L., Perlmann, P., 1984. Monoclonal antibodies to antigens associated with transitional-cell carcinoma of the human urinary bladder. I. Determination of the selectivity of six antibodies by cell-ELISA and immunofluorescence. Cancer Immunol. Immunother. 17, 165.
18. Lu, Y.A., Clavijo, P., Galantino, M., Shen, Z.-Y., Liu, W., Tam, J.P., 1991. Chemically unambiguous peptide immunogen: Preparation, orientation and antigenicity of purified peptide conjugated to the multiple antigen peptide system. Mol. Immunol. 28, 623.
19. Lucas, C., Fendly, B.M., Mukku, V.R., Wong, W.L., Palladino, M.A., 1991. Generation of antibodies and assays for transforming growth factor β. Methods Enzymol. 198, 303.
20. Mahale, S.D., Pereira, J., Natraj, U., Iyer, K.S.N., 1996. Comparison of antibodies raised against the peptide 10-24 of chicken riboflavin carrier protein (cRCP) by classical and multiple antigen peptide (MAP) approaches. J. Immunol. Methods 190, 215.
21. McLean, G.W., Owsianka, A.M., Subak-Sharpe, J.H., Marsden, H.S., 1991. Generation of anti-peptide and anti-protein sera. Effect of peptide presentation on immunogenicity. J. Immunol. Methods 137, 149.
22. Munesinghe, D.Y., Clavijo, P., Calle, M.C., Nussenzweig, R.S., Nardin, E., 1991. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21, 3015.
23. Plowman, G.D., Green, J.M., McDonald, V.L., Neubauer, M.G., Disteche, C.M., Todaro, G.J., Shoyab, M., 1990. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol. Cell. Biol. 10, 1969.
24. Prieto, I., Hervás-Stubbs, S., García-Granero, M., Berasain, C., Riezu-Boj, J.-I., Lasarte, J.-J., Sarobe, P., Prieto, J., Borrás-Cuesta, F., 1995. Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity. Eur. J. Immunol. 25, 877.
25. Sarobe, P., Lasarte, J.-J., Golvano, J., Gullon, A., Civeira, M.-P., Prieto, J., Borrás-Cuesta, F., 1991. Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide. Eur. J. Immunol. 21, 1555.
26. Schoenhaut, D.S., Chua, A.O., Wolitzky, A.G., Quinn, P.M., Dwyer, C.M., McComas, W., Familletti, P.C., Gately, M.K., Gubler, U., 1992. Cloning and expression of murine IL-12. J. Immunol. 148, 3433.
27. Sällberg, M., Rudén, U., Magnius, L.O., Norrby, F., Wahren, B., 1991. Rapid 'tea-bag' peptide synthesis using 9-fluorenylmethoxycarbonyl (Fmoc) protected amino acids applied for antigenic mapping of viral proteins. Immunol. Lett. 30, 59.
28. Tam, J.P., 1988. Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigen system. Proc. Natl. Acad. Sci. USA 85, 5409.
29. Tam, J.P., Lu, Y.-A., 1989. Vaccine engineering: Enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes. Proc. Natl. Acad. Sci. USA 86, 9084.
30. Tam, J.P., Zavala, F., 1989. Multiple antigen peptide. A novel approach to increase detection sensitivity of synthetic peptides in solid-phase immunoassays. J. Immunol. Methods 124, 53.
31. Wolf, S.F., Temple, P.A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, C., Hewick, R.M., Kelleher, K., Herrmann, S.H., Clark, S.C., Azzoni, L., Chan, S.H., Trinchieri, G., Perussia, B., 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146, 3074.
32. Xing, P.-X., Russell, S., Prenzoska, J., McKenzie, I.F.C., 1994. Discrimination between alternatively spliced STP-A and -B isoforms of CD46. Immunol. 83, 122.
33. Zegers, N.D., van Holten, C., Claassen, E., Boersma, W.J.A., 1993. Peptide-induced memory (IgG) response, cross-reactive with native proteins, requires covalent linkage of a specific B cell epitope with a T cell epitope. Eur. J. Immunol. 23, 630.