Mechanism of the impairment of the glucagon-stimulated phosphoenolpyruvate carboxykinase gene expression by interleukin-6 in rat hepatocytes: Inhibition of the increase in cyclic ',5' adenosine monophosphate and the downstream cyclic 3',5' adenosine monophosphate action

Hepatology

Volumn 26, Issue 1, 1997, Pages 73-80

  Christ, Bruno ^a   Nath, Annegret ^a   Jungermann, Kurt ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; INTERLEUKIN 6; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ACUTE PHASE RESPONSE; ANIMAL CELL; ARTICLE; ENHANCER REGION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; LIVER DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION;

EID: 0030981553     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260110     Document Type: Article

References (45)

1. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-636.
2. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL6 and related molecules (IL1 and TNF). FASEB J 1990;4: 2860-2867.
3. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130. Cell 1989;58:573-581.
4. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp 130. Cell 1990;63:1149-1157.
5. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A 1993;90:2207-2211.
6. Wegenka UM, Buschmann J, Lütticken C, Heinrich PC, Horn F. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin 6 at the posttranslational level. Mol Cell Biol 1993;13:276-288.
7. Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, et al. Association of transcription factor APRF and protein kinase JAK1 with the interleukin-6 signal transducer gp 130. Science 1994;263:89-92.
8. Lemaigre FP, Rousseau GG. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Biochem J 1994;303: 1-14.
9. Roesler WJ, Vandenbark GR, Hanson RW. Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene. J Biol Chem 1989;264: 9657-9664.
10. Magnuson MA, Granner DK. Use of fusion genes to analyze the effect of insulin on PEPCK gene transcription. In: Kahn CR, Harrison LC, eds. Insulin Action. New York: Liss, 1989:153-162.
11. Giralt M, Park EA, Gurney AL, Liu J, Hakimi P, Hanson RW. Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. J Biol Chem 1991;266:21991-21996.
12. Short MK, Clouthier DE, Shaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol 1992;12:1007-1020.
13. Eisenberger CL, Nechushtan H, Cohen H, Shani M, Reshef L. Differential regulation of the rat phosphoenolpyruvate carboxykinase gene expression in several tissues in transgenic mice. Mol Cell Biol 1992;12: 1396-1403.
14. Gurney AL, Park EA, Liu J, Giralt M, McGrane MM, Patel YM, Crawford DR, et al. Metabolic regulation of gene transcription. J Nutr 1994;124: 1533S-1539S.
15. Wadzinski BE, Wheat WH, Jaspers S, Peruski LF Jr., Lickteig RL, Johnson GL, Klemm DJ. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol Cell Biol 1993;13:2822-2834.
16. Liu J, Park EA, Gurney AL, Roesler WJ, Hanson RW. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J Biol Chem 1991;266: 19095-19102.
17. Park EA, Roesler WJ, Liu J, Klemm DJ, Gurney AL, Thatcher JD, Shuman J, et al. The role of CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase. Mol Cell Biol 1990;10:6264-6272.
18. Park EA, Gurney AL, Nizielski SE, Hakimi P, Cao Z, Moorman A, Hanson RW. Relative roles of CCAAT/enhancer-binding protein β and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 1993;268:613-619.
19. Memon RA, Feingold KR, Grunfield C. The effects of cytokines on intermediary metabolism. The Endocrinologist 1994;4:56-63.
20. Filkins JP. Monokines and the metabolic pathophysiology of septic shock. Fed Proc 1985;44:300-304.
21. Filkins JP, Cornell RP. Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock. Am J Physiol 1974;227:778-781.
22. Goto M, Zeller P, Lichtenberg RC. Decreased gluconeogenesis and increased glucose disposal without hyperinsulinemia in 10-day-old rats with endotoxic shock. Metabolism 1994;43:1248-1254.
23. Hill M, McCallum R. Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest 1991;88:811-816.
24. Deutschmann CS, De Maio A, Buchman TG, Clemens MG. Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression: the role of insulin and glucagon. Circ Shock 1993;40:295-302.
25. Christ B, Nath A, Heinrich, PC, Jungermann K. Inhibition by recombinant human interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and of the insulin-dependent induction of glucokinase gene expression in cultured rat hepatocytes: regulation of gene transcription and messenger RNA degradation. HEPATOLOGY 1994;20:1577-1583.
26. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JF, Smith JA, Struhl K, eds. Current Protocols in Molecular Biology. New York: Greene Publishing Associates, Inc. and John Wiley & Sons, Inc., 1993.
27. Christ B, Nath A, Jungermann K. Mechanism of the inhibition by insulin of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Biol Chem Hoppe-Seyler 1990;371:395-402.
28. Christ B, Nath A, Bastian H, Jungermann K. Regulation of the expression of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes by glucagon and insulin. Eur J Biochem 1988;178:373-379.
29. Bartels H, Linnemann H, Jungermann K. Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization. FEBS Lett 1989;248:188-194.
30. Gårdlund B, Sjölin J, Nilsson A, Roll M, Wickerts CJ, Wretlind B. Plasma levels of cytokines in primary septic shock in humans: correlation with disease severity. J Infect Dis 1995;172:296-301.
31. Schönbohn H, Schuler M, Kolbe K, Peschel C, Huber C, Bemb W, Aulitzky WE. Plasma levels of IL1, TNFα, IL6, IL8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia. Ann Hematol 1995;71:161-168.
32. Engel A, Kern WV, Murdter G, Kern P. Kinetics and correlation with body temperature of circulating IL6, IL8, TNFα and IL1β in patients with fever and neutropenia. Infection 1994;22:160-164.
33. Ross EM, Gilman AG. Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem 1980;49:533-564.
34. 2 of glucagon-induced increase in phosphoenolpyruvate carboxykinase mRNA and acceleration of mRNA degradation in cultured rat hepatocytes. FEBS Lett 1994;351: 353-356.
35. Pilkis, SJ, Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 1992;54:885-909.
36. Hibi M, Nakajima K, Hirano T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med 1996;74:1-12.
37. Chung MK, Gulick TS, Rotondo RE, Schreiner GF, Lange LG. Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction. Circ Res 1990;67:753-763.
38. Grimaldi M, Meucci O, Scorzielle A, Florio T, Ventra C, DeMercato R, Schettini G. Interleukin 6 modulation of second messenger systems in anterior pituitary cells. Life Sci 1992;51:1243-1248.
39. Krogh-Rasmussen A, Kayser L, Bech K, Feldt-Rasmussen U, Perrild H, Bendtzen K. Acta Endocrinol Copenh 1991;124:577-582.
40. Hanson RW, Patel YM. Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme. Adv Enzymol 1994;69:203-281.
41. Tsukada J, Saito K, Waterman WR, Webb AC, Auron PE. Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1β gene. Mol Cell Biol 1994;14:7285-7297.
42. Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J Biol Chem 1995;270:24965-24971.
43. Deutschman CS, DeMaio A, Clemens MG. Sepsis-induced attenuation of glucagon and 8-BrcAMP modulation of the phosphoenolpyruvate carboxykinase gene. Am J Physiol 1995;269:R584-R591.
44. Wang K, Deutschman CS, Clemens MG, DeMaio A. Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock 1995;3:204-209.
45. Christ B, Nath A. Impairment by IL1β and TNFα of the glucagon-induced phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis in cultured rat hepatocytes. Biochem J 1996;320: 161-166.