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Volumn 12, Issue 3, 1997, Pages 218-223

The role of cytokines in disease progression in heart failure

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ENDOTHELIN; INTERLEUKIN 6; NEUROHORMONE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 0030981046     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001573-199705000-00002     Document Type: Review
Times cited : (96)

References (55)
  • 1
    • 0027467093 scopus 로고
    • How should physicians view heart failure? The philosophical and physiological evolution of three conceptual models of the disease
    • Packer M: How should physicians view heart failure? The philosophical and physiological evolution of three conceptual models of the disease. Am J Cardiol 1993, 71:C3-C11.
    • (1993) Am J Cardiol , vol.71
    • Packer, M.1
  • 2
    • 0026695294 scopus 로고
    • The neurohormonal hypothesis: A theory to explain the mechanism of disease progression in heart failure
    • Packer M: The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol 1992, 20:248-254.
    • (1992) J Am Coll Cardiol , vol.20 , pp. 248-254
    • Packer, M.1
  • 3
    • 0029097545 scopus 로고
    • Tumor necrosis factor-α and cardiac remodeling
    • August/September
    • Mann DL, Lee-Jackson D, Yokoyama T: Tumor necrosis factor-α and cardiac remodeling. Heart Failure 1995; August/September:166-175.
    • (1995) Heart Failure , pp. 166-175
    • Mann, D.L.1    Lee-Jackson, D.2    Yokoyama, T.3
  • 5
    • 0028271405 scopus 로고
    • Basic mechanisms in congestive heart failure: Recognizing the role of proinflammatory cytokines
    • Mann DL, Young JB: Basic mechanisms in congestive heart failure: recognizing the role of proinflammatory cytokines. Chest 1994, 105:897-904.
    • (1994) Chest , vol.105 , pp. 897-904
    • Mann, D.L.1    Young, J.B.2
  • 7
    • 0027441128 scopus 로고
    • Endothelin in cardiopulmonary disease: Factor paracrine vs neurohumoral
    • Stewart DJ: Endothelin in cardiopulmonary disease: factor paracrine vs neurohumoral. Eur Heart J 1993, 14:48-54.
    • (1993) Eur Heart J , vol.14 , pp. 48-54
    • Stewart, D.J.1
  • 9
    • 0028245569 scopus 로고
    • Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure
    • Tsutamoto T, Wada A, Maeda Y, Adachi T, Kinoshita M: Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure. J Am Coll Cardiol 1994, 23:1427-1433.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 1427-1433
    • Tsutamoto, T.1    Wada, A.2    Maeda, Y.3    Adachi, T.4    Kinoshita, M.5
  • 10
    • 0027319429 scopus 로고
    • Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture
    • Nishida M, Springhorn JP, Kelly RA, Smith TW: Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture. J Clin Invest 1993, 91:1934-1941.
    • (1993) J Clin Invest , vol.91 , pp. 1934-1941
    • Nishida, M.1    Springhorn, J.P.2    Kelly, R.A.3    Smith, T.W.4
  • 11
    • 0027257160 scopus 로고
    • Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin-II-induced hypertrophy in cultured rat cardiomyocytes
    • Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Marumo F, Hiroe M: Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin-II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993, 92:398-403.
    • (1993) J Clin Invest , vol.92 , pp. 398-403
    • Ito, H.1    Hirata, Y.2    Adachi, S.3    Tanaka, M.4    Tsujino, M.5    Koike, A.6    Nogami, A.7    Marumo, F.8    Hiroe, M.9
  • 12
    • 0025133013 scopus 로고
    • Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway
    • Kelly RA, Eid H, Kramer BK, O'Neill M, Liang BT, Reers M, Smith TW: Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway. J Clin Invest 1990, 86:1164-1171.
    • (1990) J Clin Invest , vol.86 , pp. 1164-1171
    • Kelly, R.A.1    Eid, H.2    Kramer, B.K.3    O'Neill, M.4    Liang, B.T.5    Reers, M.6    Smith, T.W.7
  • 13
    • 0029918005 scopus 로고    scopus 로고
    • Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure: Marked increase in endothelin-1 production in the failing heart
    • Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y: Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure: marked increase in endothelin-1 production in the failing heart. Circulation 1996, 93:1214-1222. This study provides evidence that the endogenous expression of endothelin-1 in the myocardium may initially by compensatory by providing increased contractile support to the failing myocardium.
    • (1996) Circulation , vol.93 , pp. 1214-1222
    • Sakai, S.1    Miyauchi, T.2    Sakurai, T.3    Kasuya, Y.4    Ihara, M.5    Yamaguchi, I.6    Goto, K.7    Sugishita, Y.8
  • 14
    • 0026447109 scopus 로고
    • Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes
    • Jones LG, Rozich JD, Tsutsui H, Cooper G: Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes. Am J Physiol 1992, 263:H1447-H1454.
    • (1992) Am J Physiol , vol.263
    • Jones, L.G.1    Rozich, J.D.2    Tsutsui, H.3    Cooper, G.4
  • 15
    • 0028230940 scopus 로고
    • Structural remodeling in hypertensive heart disease and the role of hormones
    • Weber KT, Sun Y, Guarda E: Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 1994, 23:869-877.
    • (1994) Hypertension , vol.23 , pp. 869-877
    • Weber, K.T.1    Sun, Y.2    Guarda, E.3
  • 16
    • 0029950405 scopus 로고    scopus 로고
    • Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
    • Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y: Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature 1996, 384:353-355. This important experimental study in rats shows that blocking the endothelin-A receptor with a specific antagonist prevents myocardial remodeling (dilatation). myocardial fibrosis, and myocardial dysfunction. Thus. this study provides a compelling rationale for the use of endothelin receptor antagonists to prevent disease progression in heart failure.
    • (1996) Nature , vol.384 , pp. 353-355
    • Sakai, S.1    Miyauchi, T.2    Kobayashi, M.3    Yamaguchi, I.4    Goto, K.5    Sugishita, Y.6
  • 18
    • 0027160401 scopus 로고
    • Influence of congestive heart failure on endothelin levels and receptors in rabbits
    • Loffler BM, Roux S, Kalina B, Clozel M, Clozel J-P: Influence of congestive heart failure on endothelin levels and receptors in rabbits. J Mol Cell Cardiol 1993, 25:407-416.
    • (1993) J Mol Cell Cardiol , vol.25 , pp. 407-416
    • Loffler, B.M.1    Roux, S.2    Kalina, B.3    Clozel, M.4    Clozel, J.-P.5
  • 20
    • 8244257761 scopus 로고
    • Evolution of plasma endothelin and renin activity levels in a rat model of congestive heart failure
    • Teerlink JR, Clozel J-P, Loffler BM, Fischli W, Clozel M: Evolution of plasma endothelin and renin activity levels in a rat model of congestive heart failure. Circulation 1992, 86:1-430.
    • (1992) Circulation , vol.86 , pp. 1-430
    • Teerlink, J.R.1    Clozel, J.-P.2    Loffler, B.M.3    Fischli, W.4    Clozel, M.5
  • 21
    • 0029087262 scopus 로고
    • Evidence for endothelin-1 mediated vasoconstriction in severe chronic heart failure
    • Kiowski W, Sutsch G, Hunziker P, Muller P, Kim J, Oechslin E, Schmitt R, Jones R, Bertel O: Evidence for endothelin-1 mediated vasoconstriction in severe chronic heart failure. Lancet 1995, 346:732-736. This clinical study provides the first evidence that a nonspecific endothelin receptor antagonist (bosentan) is effective is the clinical setting of clinical heart failure in terms of decreasing peripheral vascular resistance and increasing cardiac output.
    • (1995) Lancet , vol.346 , pp. 732-736
    • Kiowski, W.1    Sutsch, G.2    Hunziker, P.3    Muller, P.4    Kim, J.5    Oechslin, E.6    Schmitt, R.7    Jones, R.8    Bertel, O.9
  • 22
    • 0025221348 scopus 로고
    • Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes
    • Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR: Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. J Biol Chem 1990, 265:20555-20562.
    • (1990) J Biol Chem , vol.265 , pp. 20555-20562
    • Shubeita, H.E.1    McDonough, P.M.2    Harris, A.N.3    Knowlton, K.U.4    Glembotski, C.C.5    Brown, J.H.6    Chien, K.R.7
  • 23
    • 0029880929 scopus 로고    scopus 로고
    • Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure
    • Pacher R, Stanek B, Hulsmann M, Koller-Strametz J, Berger R, Schuller M, Hartter E, Ogris E, Frey B, Heinz G, Maurer G: Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure. J Am Coll Cardiol 1996, 27:633-641. This study shows that elevated levels of endothelin-1 correlate with prognosis for patients with heart failure.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 633-641
    • Pacher, R.1    Stanek, B.2    Hulsmann, M.3    Koller-Strametz, J.4    Berger, R.5    Schuller, M.6    Hartter, E.7    Ogris, E.8    Frey, B.9    Heinz, G.10    Maurer, G.11
  • 24
    • 0028982826 scopus 로고
    • Tumor necrosis factor gene and protein expression in adult feline myocardium after endotoxin administration
    • Kapadia S, Lee JR, Torre-Amione G, Birdsall HH, Ma TS, Mann DL: Tumor necrosis factor gene and protein expression in adult feline myocardium after endotoxin administration. J Clin Invest 1995, 96:1042-1052.
    • (1995) J Clin Invest , vol.96 , pp. 1042-1052
    • Kapadia, S.1    Lee, J.R.2    Torre-Amione, G.3    Birdsall, H.H.4    Ma, T.S.5    Mann, D.L.6
  • 25
    • 0029670957 scopus 로고    scopus 로고
    • Tumor necrosis factor-α and tumor necrosis factor receptors in the failing heart
    • Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, Mann DL: Tumor necrosis factor-α and tumor necrosis factor receptors in the failing heart. Circulation 1996, 93:704-711. This study was the first to show that both TNF-α mRNA and protein are expressed in the failing hearts of patients with ischemic heart disease and dilated cardiomyopathy, whereas there was no evidence for TNF-α mRNA and protein expression in the nonfailing heart. This study also showed that TNF receptors were downregulated in the failing heart as compared with normal hearts, suggesting that the heart was a target organ for TNF-α in heart failure. Thus, these studies provide an important conceptual understanding of an important source of cytokine production in heart failure.
    • (1996) Circulation , vol.93 , pp. 704-711
    • Torre-Amione, G.1    Kapadia, S.2    Lee, J.3    Durand, J.B.4    Bies, R.D.5    Young, J.B.6    Mann, D.L.7
  • 26
    • 0030603619 scopus 로고    scopus 로고
    • Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
    • Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM: Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996, 347:1151-1155. This study provided important confirmation for the study by Torre-Amione et al. (Circulation 1996, 93:704-711), in that it also demonstrated the presence of TNF-α immunoreactivity in patients with dilated cardiomyopathy. In addition, these authors demonstrated the presence of immunoreactivity for the inducible form of nitric oxide synthase in patients with dilated and ischemic cardiomyopathy.
    • (1996) Lancet , vol.347 , pp. 1151-1155
    • Habib, F.M.1    Springall, D.R.2    Davies, G.J.3    Oakley, C.M.4    Yacoub, M.H.5    Polak, J.M.6
  • 27
    • 0029670957 scopus 로고    scopus 로고
    • Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM: Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996, 347:1151-1155. This study provided important confirmation for the study by Torre-Amione et al. (Circulation 1996, 93:704-711), in that it also demonstrated the presence of TNF-α immunoreactivity in patients with dilated cardiomyopathy. In addition, these authors demonstrated the presence of immunoreactivity for the inducible form of nitric oxide synthase in patients with dilated and ischemic cardiomyopathy.
    • (1996) Circulation , vol.93 , pp. 704-711
    • Torre-Amione1
  • 28
    • 0029089653 scopus 로고
    • Expression and functional significance of tumor necrosis factor receptors in human myocardium
    • Torre-Amione G, Kapadia S. Lee J, Bies RD, Lebovitz R, Mann DL: Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation 1995, 92:1487-1493.
    • (1995) Circulation , vol.92 , pp. 1487-1493
    • Torre-Amione, G.1    Kapadia, S.2    Lee, J.3    Bies, R.D.4    Lebovitz, R.5    Mann, D.L.6
  • 29
    • 0030453430 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced apoptosis in cardiac myocytes: Involvement of the sphingolipid signaling cascade in cardiac cell death
    • Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJE: Tumor necrosis factor-α-induced apoptosis in cardiac myocytes: involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest 1996, 98:2854-2865. This study showed that elevated concentrations of TNF-α were sufficient to produce cell apoptotic (programmed) cell death in culture cardiac myocytes, thus providing a potential link between the elaboration of TNF-α in heart failure and progressive myocyte cell loss.
    • (1996) J Clin Invest , vol.98 , pp. 2854-2865
    • Krown, K.A.1    Page, M.T.2    Nguyen, C.3    Zechner, D.4    Gutierrez, V.5    Comstock, K.L.6    Glembotski, C.C.7    Quintana, P.J.E.8
  • 30
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine B, Kalman J, Mayer L, Fillit HM, Packer M: Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990, 223:236-241.
    • (1990) N Engl J Med , vol.223 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3    Fillit, H.M.4    Packer, M.5
  • 31
    • 0029912883 scopus 로고    scopus 로고
    • Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    • Munger MA, Johnson B, Amber IJ, Callahan KS, Gilbert EM: Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 1996, 77:723-727.
    • (1996) Am J Cardiol , vol.77 , pp. 723-727
    • Munger, M.A.1    Johnson, B.2    Amber, I.J.3    Callahan, K.S.4    Gilbert, E.M.5
  • 32
    • 0030273548 scopus 로고    scopus 로고
    • Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension
    • Testa M, Yeh M, Lee P, Fanelli R, Loperfido F, Berman JW, LeJemtel TH: Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 1996, 28:964-971. This clinical study shows that elevated levels of TNF-α and TNFR2 are elevated in direct relation to NYHA functional class. In addition, this is the first study to demonstrate the presence of interleukin-1 in patients with heart failure.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 964-971
    • Testa, M.1    Yeh, M.2    Lee, P.3    Fanelli, R.4    Loperfido, F.5    Berman, J.W.6    LeJemtel, T.H.7
  • 33
    • 0029958555 scopus 로고    scopus 로고
    • The clinical relevance of circulating tumor necrosis factor-α in acute decompensated chronic heart failure without cachexia
    • Milani RV, Mehra MR, Endres S, Eigler A, Cooper S, Lavie Jr, Ventura HO.: The clinical relevance of circulating tumor necrosis factor-α in acute decompensated chronic heart failure without cachexia. Chest 1996, 110:992-997.
    • (1996) Chest , vol.110 , pp. 992-997
    • Milani, R.V.1    Mehra, M.R.2    Endres, S.3    Eigler, A.4    Cooper, S.5    Lavie, Jr.6    Ventura, H.O.7
  • 34
    • 0026047605 scopus 로고
    • Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure
    • McMurray J, Abdullah I, Dargie HJ, Shapiro D: Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure. Br Heart J 1991, 66:356-358.
    • (1991) Br Heart J , vol.66 , pp. 356-358
    • McMurray, J.1    Abdullah, I.2    Dargie, H.J.3    Shapiro, D.4
  • 35
    • 0027486556 scopus 로고
    • Increased levels of serum neopterin and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha
    • Wiedermann CJ, Beimpold H, Herold M, Knapp E. Braunsteiner H: Increased levels of serum neopterin and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha. J Am Coll Cardiol 1993, 22:1897-1901.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 1897-1901
    • Wiedermann, C.J.1    Beimpold, H.2    Herold, M.3    Knapp, E.4    Braunsteiner, H.5
  • 37
    • 0028356323 scopus 로고
    • Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure: Relation to nitric oxide-dependent vasodilation in the forearm circulation
    • Katz SD, Rao R, Berman JW, Schwarz M, Demopoulos L, Bijou R, LeJemtel TH: Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure: relation to nitric oxide-dependent vasodilation in the forearm circulation. Circulation 1994, 90:12-16.
    • (1994) Circulation , vol.90 , pp. 12-16
    • Katz, S.D.1    Rao, R.2    Berman, J.W.3    Schwarz, M.4    Demopoulos, L.5    Bijou, R.6    LeJemtel, T.H.7
  • 38
    • 0028171632 scopus 로고
    • Increased circulating cytokines in patients with myocarditis and cardiomyopathy
    • Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S: Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J 1994, 72:561-566.
    • (1994) Br Heart J , vol.72 , pp. 561-566
    • Matsumori, A.1    Yamada, T.2    Suzuki, H.3    Matoba, Y.4    Sasayama, S.5
  • 39
    • 0029117828 scopus 로고
    • Tumor necrosis factor soluble receptors in patients with various degrees of congestive failure
    • Ferrari R, Bachetti T, Confortini R, Opasich C, Febo O, Corti A, Cassani G, Visioli O: Tumor necrosis factor soluble receptors in patients with various degrees of congestive failure. Circulation 1995, 92:1479-1486. This clinical study was the first to document the presence of elevated levels of soluble TNF receptors in patients with heart failure and the first study to show that increased levels of TNF receptors correlated with worse prognosis in patients with heart failure. This study also showed that TNF-α levels were most elevated in the patients with the worst clinical outcomes.
    • (1995) Circulation , vol.92 , pp. 1479-1486
    • Ferrari, R.1    Bachetti, T.2    Confortini, R.3    Opasich, C.4    Febo, O.5    Corti, A.6    Cassani, G.7    Visioli, O.8
  • 40
    • 0029871896 scopus 로고    scopus 로고
    • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
    • Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL: Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol 1996, 27:1201-1206 This important clinical study was the first to show that both TNF-α and interleukin-6 levels were elevated in direct relation to deteriorating NYHA functional class for patients enrolled in SOLVD. This study also showed that there was no relationship between neurohormonal levels and elevated cytokine levels, suggesting that the elaboration of neurohormones was not the mechanism for cytokine expression in heart failure.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1201-1206
    • Torre-Amione, G.1    Kapadia, S.2    Benedict, C.3    Oral, H.4    Young, J.B.5    Mann, D.L.6
  • 43
    • 0024437786 scopus 로고
    • Tumor necrosis factor in bronchopulmonary secretions of patients with adult respiratory distress syndrome
    • Millar AB, Singer M, Meager A, Foley NM, Johnson NM, Rook GA: Tumor necrosis factor in bronchopulmonary secretions of patients with adult respiratory distress syndrome. Lancet 1989, ii:712-713.
    • (1989) Lancet , vol.2 , pp. 712-713
    • Millar, A.B.1    Singer, M.2    Meager, A.3    Foley, N.M.4    Johnson, N.M.5    Rook, G.A.6
  • 44
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction
    • The SOLVD Investigators: Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction. N Engl J Med 1992, 327:685-691.
    • (1992) N Engl J Med , vol.327 , pp. 685-691
  • 45
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patents with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators: Effect of enalapril on survival in patents with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991, 325:293-302.
    • (1991) N Engl J Med , vol.325 , pp. 293-302
  • 46
    • 0024381672 scopus 로고
    • Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure
    • Gottleib SS, Hukin ML, Ahern D, Packer M: Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure. J Am Coll Cardiol 1989, 13:1534-1539.
    • (1989) J Am Coll Cardiol , vol.13 , pp. 1534-1539
    • Gottleib, S.S.1    Hukin, M.L.2    Ahern, D.3    Packer, M.4
  • 48
    • 0025165135 scopus 로고
    • Two tumor necrosis factor-binding proteins purified from human urine
    • Engelmann GL, Novick D, Wallach D: Two tumor necrosis factor-binding proteins purified from human urine. J Biol Chem 1990, 265:1531-1536.
    • (1990) J Biol Chem , vol.265 , pp. 1531-1536
    • Engelmann, G.L.1    Novick, D.2    Wallach, D.3
  • 49
    • 0026563754 scopus 로고
    • Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor
    • Brakebusch C, Nophar Y, Kemper O, Engelmann H, Wallach D: Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor. EMBO J 1992, 11:943-950.
    • (1992) EMBO J , vol.11 , pp. 943-950
    • Brakebusch, C.1    Nophar, Y.2    Kemper, O.3    Engelmann, H.4    Wallach, D.5
  • 50
    • 0028898719 scopus 로고
    • Soluble tumor necrosis factor binding proteins modulate the negative inotropic effects of TNF-α in vitro
    • Kapadia S, Torre-Amione G, Yokoyama T, Mann DL: Soluble tumor necrosis factor binding proteins modulate the negative inotropic effects of TNF-α in vitro. Am J Physiol 1995, 37:H517-H525
    • (1995) Am J Physiol , vol.37
    • Kapadia, S.1    Torre-Amione, G.2    Yokoyama, T.3    Mann, D.L.4
  • 51
    • 0026516744 scopus 로고
    • Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors
    • Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D: Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 1992, 175:323-329.
    • (1992) J Exp Med , vol.175 , pp. 323-329
    • Aderka, D.1    Engelmann, H.2    Maor, Y.3    Brakebusch, C.4    Wallach, D.5
  • 54
    • 0007381668 scopus 로고
    • Plasma concentration of interleukin-6 as a marker of prognosis in patients with chronic congestive heart failure
    • Tsutamoto T, Hisanaga T, Wada A, Maeda Y, Fukai D: Plasma concentration of interleukin-6 as a marker of prognosis in patients with chronic congestive heart failure. Circulation 1994, 90:1-381
    • (1994) Circulation , vol.90 , pp. 1-381
    • Tsutamoto, T.1    Hisanaga, T.2    Wada, A.3    Maeda, Y.4    Fukai, D.5
  • 55
    • 0000917298 scopus 로고
    • Interleukin-6
    • Edited by Thompson A. Boston: Academic Press
    • Hirano T: Interleukin-6. In The Cytokine Handbook. Edited by Thompson A. Boston: Academic Press; 1991:169-190.
    • (1991) The Cytokine Handbook , pp. 169-190
    • Hirano, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.