Autoantibodies to p53 in ovarian cancer patients and healthy women: A comparison between whole p53 protein and 18-mer peptides for screening purposes

Cancer Letters

Volumn 116, Issue 1, 1997, Pages 93-101

  Vennegoor, Claus J G M ^a   Nijman, Hans W ^a,b   Drijfhout, Jan Wouter ^b   Vernie, Leen ^c   Verstraeten, Rob A ^a   Von Mensdorff Pouilly, Silvia ^a   Hilgers, Jo ^a   Verheijen, René H M ^a   Kast, W Martin ^d   Melief, Cornelis J M ^b   Kenemans, Peter ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Autoantibodies; Human; Ovarian cancer; p53; Tumor suppressor gene

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M ANTIBODY; PROTEIN P53;

ANTIBODY BLOOD LEVEL; ARTICLE; CANCER PATIENT; CANCER SCREENING; CANCER STAGING; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; HELPER CELL; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; OVARY CANCER; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

AUTOANTIBODIES; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OVARIAN NEOPLASMS; PEPTIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030979896     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00168-7     Document Type: Article

References (35)

1. Hupp, T.R. and Lane, D.P. (1994) Allosteric activation of latent p53 tetramers, Curr. Biol., 4, 865-875.
2. Kupryjanczyk, J., Thor, A.D., Beauchamp, R., Merritt, V., Edgerton, S.M., Bell, D.A. and Yandell, D.W. (1993) p53 gene mutations and protein accumulation in human ovarian cancer, Proc. Natl. Acad. Sci. USA, 90, 4961-4965.
3. Nijman, H.W., van der Burg, S.H., Vierboom, M.P.M., Houbiers, J.G.A., Kast, W.M. and Melief, C.J.M. (1994) p53, a potential target for tumor-directed T cells, Immunol. Lett., 40, 171-178.
4. Houbiers, J.G.A., Nijman, H.W., van der Burg, S.H., Drijfhout, J.W., Kenemans, P., van de Velde, C.J.H., Brand, A., Momburg, F., Kast, W.M. and Melief, C.J.M. (1993) In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53, Eur. J. Immunol., 23, 2072-2077.
5. + cytotoxic T-cells, Cancer Res., 53, 3257-3261.
6. + T cells, Proc. Natl. Acad. Sci. USA, 91, 3171-3175.
7. Noguchi, Y., Richards, E.C., Chen, Y.-T. and Old, L.J. (1995) Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma, Proc. Natl. Acad. Sci. USA, 92, 2219-2223.
8. Theobald, M., Biggs, J., Dittmer, D., Levine, A.J. and Sherman, L.A. (1995) Targeting p53 as a general tumor antigen, Proc. Natl. Acad. Sci. USA, 92, 11993-11997.
9. Lubin, R., Schlichtholz, B., Bengoufa, D., Zalcman, G., Trédaniel, J., Hirsch, A., Caron de Fromentel, C., Preudhomme, C., Fenaux, P., Fournier, G., Mangin, P., Laurent-Puig, P., Pelletier, G., Schlumberger, M., Desgrandchamps, F., Le Duc, A., Peyrat, J.P., Janin, N., Bressac, B. and Soussi, T. (1993) Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface, Cancer Res., 53, 5872-5876.
10. Schlichtholz, B., Trédaniel, J., Lubin, R., Zalcman, G., Hirsch, A. and Soussi, T. (1994) Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein, Br. J. Cancer, 69, 809-816.
11. Angelopoulou, K., Diamandis, E.P., Sutherland, D.J.A., Kellen, J.A. and Bunting, P.S. (1994) Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers, Int. J. Cancer, 58, 480-487.
12. Lubin, R., Schlichtholz, B., Teillaud, J.L., Garay, E., Bussel, A., Wild, C.P. and Soussi, T. (1995) p53 antibodies in patients with various types of cancer: assay, identification, and characterization, Clin. Cancer Res., 1, 1463-1469.
13. Ley, V., Langlade-Demoyen, P., Kourilsky, P. and Larsson-Sciard, E.-L. (1991) Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo., Eur. J. Immunol., 21, 851-854.
14. + T helper subsets in human melanoma, Surgery, 117, 365-372.
15. Filley, E., Thole, J.E.R., Rook, G.A.W., Nagai, S., Waters, M., Drijfhout, J.W., Rinke de Wit, T.F., de Vries, R.R.P. and Abou-Zeid, C. (1994) Identification of an antigenic domain on Mycobacterium leprae protein antigen 85B, which is specifically recognized by antibodies from patients with leprosy, J. Infect. Dis., 169, 162-169.
16. Reimer, J.R., Skvaril, C.B., de Lange, G., Ling, N.R., Lowe, J., Walker, M.R., Phillips, D.J., Aloisio, C.H., Wells, T.W., Vaerman, J.P., Magnusson, C.G., Kubagawa, H., Cooper, M., Vartdal, F., Vandvik, B., Haaijman, J.J., Makela, O., Sarnesto, A., Lando, Z., Gergely, J., Rajnavölgyi, E., Lászió, G., Radi, J. and Molinaro, G.A. (1985) Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study, Immunol. Lett., 10, 223-252.
17. Masuda, H., Miller, C., Koeffler, H.P., Battifora, H. and Cline, M.J. (1987) Rearrangement of the p53 gene in human osteogenic sarcomas, Proc. Natl. Acad. Sci. USA, 84, 7716-7719.
18. Nigro, J.M., Baker, S.J., Preisinger, A.C., Jessup, J.M., Hostetter, R., Cleary, K., Bigner, S.H., Davidson, N., Baylin, S., Devilee, P., Gloveri, T., Collins, F.S., Weston, A., Modali, R., Harris, C.C. and Vogelstein, B. (1989) Mutations in the p53 gene occur in diverse human tumour types, Nature, 342, 705-708.
19. Schneider, C., Newman, R.A., Sutherland, D.R., Asser, U. and Greaves, M.F. (1982) A one-step purification of membrane proteins using a high efficiency immunomatrix, J. Biol. Chem., 257, 10766-10769.
20. Green, M.A., Sviland, L., Malcolm, A.J. and Pearson, A.D.J. (1989) Improved method for immunoperoxidase detection of membrane antigens in frozen sections, J. Clin. Pathol., 42, 875-880.
21. Mudenda, B., Green, J.A., Green, B., Jenkins, J.R., Robertson, L., Tarunina, M. and Leinster, S.J. (1994) The relationship between serum p53 autoantibodies and characteristics of human breast cancer, Br. J. Cancer, 69, 1115-1119.
22. Davidoff, A.M., Iglehart, J.D. and Marks, J.R. (1992) Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers, Proc. Natl. Acad. Sci. USA, 89, 3439-3442.
23. Labrecque, S., Naor, N., Thomson, D. and Matlashewski, G. (1993) Analysis of the anti-p53 antibody response in cancer patients, Cancer Res., 53, 3468-3471.
24. Vojtesek, B., Dolezalova, H., Lauerova, L., Svitakova, M., Haviis, P., Kovarik, J., Midgley, C.A. and Lane, D.P. (1995) Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein, Oncogene, 10, 389-393.
25. Bukovsky, A., Caudle, M.R., Keenan, J.A., Wimalasena, J., Foster, J.S., Upadhyaya, N.B. and van Meter, S.E. (1995) Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract, J. Assisted Reprod. Genetics, 12, 123-131.
26. Rivas, C.I., Wisniewski, D., Strife, A., Perez, A., Lambek, C., Bruno, S., Darzynkiewicz, Z. and Clarkson, B. (1992) Constitutive expression of p53 protein in enriched normal human marrow blast cell populations, Blood, 79, 1982-1986.
27. Villuendas, R., Piris, M.A., Orradre, J.L., Mollejo, M., Algara, P., Sanchez, L., Martinez, J.C. and Martinez, P. (1992) p53 protein expression in lymphomas and reactive lymphoid tissue, J. Pathol., 166, 235-241.
28. Haidacher, S., Blaschitz, A., Desoye, G. and Dohr, G. (1995) Immunohistochemical evidence of p53 protein in human placenta and choriocarcinoma cell lines, Hum. Reprod., 10, 983-988.
29. Hall, P.A., McKee, P.H., Menage, H.d.P., Dover, R. and Lane, D.P. (1993) High levels of p53 protein in UV-irradiated normal human skin, Oncogene, 8, 203-207.
30. Barnadas, M.A., Colomo, L., Curell, R. and de Moragas, J.M. (1996) Expression of the p53 protein in sun-damaged skin, Acta Derm. Venereol., 76, 203-204.
31. Muganda, P., Mendoza, O., Hernandez, J. and Qian, Q. (1994) Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts, J. Virol., 68, 8028-8034.
32. Trivers, G.E., Cawley, H.L., DeBenedetti, V.M.G., Hollstein, M., Marion, M.J., Bennett, W.P., Hoover, M.L., Prives, C.C., Tamburro, C.C. and Harris, C.C. (1995) Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride, J. Natl. Cancer Inst, 87, 1400-1407.
33. Wilson, I.A. and Stanfield, R.L.(1993) Antibody-antigen interactions. Curr. Opin. Struct. Biol., 3, 113-118.
34. Stephen, C.W., Helminen, P. and Lane, D.P. (1995) Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions, J. Mol. Biol., 248, 58-78.
35. Rizzo, L.V., DeKruyff, R.H., Umetsu, D.T. and Caspi, R.R. (1995) Regulation of the interaction between Th1 and Th2 cell clones to provide help for antibody production in vivo, Eur. J. Immunol., 25, 708-716.